D37-D48
Medium Complexity

Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes

Primary Specialty: Oncology
Last Updated: 2025-09-09

ICD-10 Codes (112)

112 billable
0 category headers
D38
Billable
Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs
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D38.0
Billable
Neoplasm of uncertain behavior of larynx
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D38.1
Billable
Neoplasm of uncertain behavior of trachea, bronchus and lung
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D38.2
Billable
Neoplasm of uncertain behavior of pleura
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D38.3
Billable
Neoplasm of uncertain behavior of mediastinum
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D38.4
Billable
Neoplasm of uncertain behavior of thymus
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D38.5
Billable
Neoplasm of uncertain behavior of other respiratory organs
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D38.6
Billable
Neoplasm of uncertain behavior of respiratory organ, unspecified
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D39
Billable
Neoplasm of uncertain behavior of female genital organs
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D39.0
Billable
Neoplasm of uncertain behavior of uterus
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D39.1
Billable
Neoplasm of uncertain behavior of ovary
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D39.10
Billable
Neoplasm of uncertain behavior of unspecified ovary
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D39.11
Billable
Neoplasm of uncertain behavior of right ovary
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D39.12
Billable
Neoplasm of uncertain behavior of left ovary
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D39.2
Billable
Neoplasm of uncertain behavior of placenta
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D39.8
Billable
Neoplasm of uncertain behavior of other specified female genital organs
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D39.9
Billable
Neoplasm of uncertain behavior of female genital organ, unspecified
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D40
Billable
Neoplasm of uncertain behavior of male genital organs
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D40.0
Billable
Neoplasm of uncertain behavior of prostate
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D40.1
Billable
Neoplasm of uncertain behavior of testis
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D40.10
Billable
Neoplasm of uncertain behavior of unspecified testis
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D40.11
Billable
Neoplasm of uncertain behavior of right testis
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D40.12
Billable
Neoplasm of uncertain behavior of left testis
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D40.8
Billable
Neoplasm of uncertain behavior of other specified male genital organs
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D40.9
Billable
Neoplasm of uncertain behavior of male genital organ, unspecified
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D41
Billable
Neoplasm of uncertain behavior of urinary organs
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D41.0
Billable
Neoplasm of uncertain behavior of kidney
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D41.00
Billable
Neoplasm of uncertain behavior of unspecified kidney
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D41.01
Billable
Neoplasm of uncertain behavior of right kidney
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D41.02
Billable
Neoplasm of uncertain behavior of left kidney
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D41.1
Billable
Neoplasm of uncertain behavior of renal pelvis
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D41.10
Billable
Neoplasm of uncertain behavior of unspecified renal pelvis
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D41.11
Billable
Neoplasm of uncertain behavior of right renal pelvis
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D41.12
Billable
Neoplasm of uncertain behavior of left renal pelvis
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D41.2
Billable
Neoplasm of uncertain behavior of ureter
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D41.20
Billable
Neoplasm of uncertain behavior of unspecified ureter
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D41.21
Billable
Neoplasm of uncertain behavior of right ureter
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D41.22
Billable
Neoplasm of uncertain behavior of left ureter
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D41.3
Billable
Neoplasm of uncertain behavior of urethra
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D41.4
Billable
Neoplasm of uncertain behavior of bladder
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D41.8
Billable
Neoplasm of uncertain behavior of other specified urinary organs
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D41.9
Billable
Neoplasm of uncertain behavior of unspecified urinary organ
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D42
Billable
Neoplasm of uncertain behavior of meninges
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D42.0
Billable
Neoplasm of uncertain behavior of cerebral meninges
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D42.1
Billable
Neoplasm of uncertain behavior of spinal meninges
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D42.9
Billable
Neoplasm of uncertain behavior of meninges, unspecified
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D43
Billable
Neoplasm of uncertain behavior of brain and central nervous system
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D43.0
Billable
Neoplasm of uncertain behavior of brain, supratentorial
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D43.1
Billable
Neoplasm of uncertain behavior of brain, infratentorial
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D43.2
Billable
Neoplasm of uncertain behavior of brain, unspecified
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D43.3
Billable
Neoplasm of uncertain behavior of cranial nerves
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D43.4
Billable
Neoplasm of uncertain behavior of spinal cord
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D43.8
Billable
Neoplasm of uncertain behavior of other specified parts of central nervous system
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D43.9
Billable
Neoplasm of uncertain behavior of central nervous system, unspecified
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D44
Billable
Neoplasm of uncertain behavior of endocrine glands
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D44.0
Billable
Neoplasm of uncertain behavior of thyroid gland
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D44.1
Billable
Neoplasm of uncertain behavior of adrenal gland
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D44.10
Billable
Neoplasm of uncertain behavior of unspecified adrenal gland
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D44.11
Billable
Neoplasm of uncertain behavior of right adrenal gland
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D44.12
Billable
Neoplasm of uncertain behavior of left adrenal gland
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D44.2
Billable
Neoplasm of uncertain behavior of parathyroid gland
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D44.3
Billable
Neoplasm of uncertain behavior of pituitary gland
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D44.4
Billable
Neoplasm of uncertain behavior of craniopharyngeal duct
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D44.5
Billable
Neoplasm of uncertain behavior of pineal gland
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D44.6
Billable
Neoplasm of uncertain behavior of carotid body
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D44.7
Billable
Neoplasm of uncertain behavior of aortic body and other paraganglia
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D44.9
Billable
Neoplasm of uncertain behavior of unspecified endocrine gland
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D45
Billable
Polycythemia vera
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D46
Billable
Myelodysplastic syndromes
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D46.0
Billable
Refractory anemia without ring sideroblasts, so stated
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D46.1
Billable
Refractory anemia with ring sideroblasts
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D46.2
Billable
Refractory anemia with excess of blasts [RAEB]
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D46.20
Billable
Refractory anemia with excess of blasts, unspecified
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D46.21
Billable
Refractory anemia with excess of blasts 1
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D46.22
Billable
Refractory anemia with excess of blasts 2
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D46.4
Billable
Refractory anemia, unspecified
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D46.9
Billable
Myelodysplastic syndrome, unspecified
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D47
Billable
Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue
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D47.0
Billable
Mast cell neoplasms of uncertain behavior
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D47.01
Billable
Cutaneous mastocytosis
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D47.02
Billable
Systemic mastocytosis
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D47.09
Billable
Other mast cell neoplasms of uncertain behavior
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D47.1
Billable
Chronic myeloproliferative disease
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D47.2
Billable
Monoclonal gammopathy
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D47.3
Billable
Essential (hemorrhagic) thrombocythemia
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D47.4
Billable
Osteomyelofibrosis
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D47.9
Billable
Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified
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D48
Billable
Neoplasm of uncertain behavior of other and unspecified sites
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D48.0
Billable
Neoplasm of uncertain behavior of bone and articular cartilage
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D48.1
Billable
Neoplasm of uncertain behavior of connective and other soft tissue
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D48.11
Billable
Desmoid tumor
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D48.110
Billable
Desmoid tumor of head and neck
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D48.111
Billable
Desmoid tumor of chest wall
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D48.112
Billable
Desmoid tumor, intrathoracic
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D48.113
Billable
Desmoid tumor of abdominal wall
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D48.114
Billable
Desmoid tumor, intraabdominal
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D48.115
Billable
Desmoid tumor of upper extremity and shoulder girdle
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D48.116
Billable
Desmoid tumor of lower extremity and pelvic girdle
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D48.117
Billable
Desmoid tumor of back
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D48.118
Billable
Desmoid tumor of other site
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D48.119
Billable
Desmoid tumor of unspecified site
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D48.19
Billable
Other specified neoplasm of uncertain behavior of connective and other soft tissue
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D48.2
Billable
Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system
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D48.3
Billable
Neoplasm of uncertain behavior of retroperitoneum
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D48.4
Billable
Neoplasm of uncertain behavior of peritoneum
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D48.5
Billable
Neoplasm of uncertain behavior of skin
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D48.6
Billable
Neoplasm of uncertain behavior of breast
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D48.60
Billable
Neoplasm of uncertain behavior of unspecified breast
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D48.61
Billable
Neoplasm of uncertain behavior of right breast
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D48.62
Billable
Neoplasm of uncertain behavior of left breast
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D48.7
Billable
Neoplasm of uncertain behavior of other specified sites
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D48.9
Billable
Neoplasm of uncertain behavior, unspecified
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Updates & Changes

FY 2026 Updates

Current Year

Deleted Codes

No codes deleted in this range for FY 2026

No significant changes for FY 2026

This range maintains stability with current coding practices

Historical Changes

  • •FY 2025: Routine maintenance updates with minor terminology clarifications
  • •FY 2024: Enhanced specificity requirements for certain code ranges
  • •FY 2023: Updated documentation guidelines for improved clarity

Upcoming Changes

  • •Proposed updates pending review by Coordination and Maintenance Committee
  • •Under consideration: Enhanced digital health integration codes

Implementation Guidance

  • •Review all FY 2026 updates for D37-D48 codes before implementation
  • •Always verify the most current codes in the ICD-10-CM manual
  • •Ensure clinical documentation supports the selected diagnosis codes
  • +3 more guidance items...

Range Overview

high priority

The ICD-10 code range D37-D48 pertains to Neoplasms of uncertain behavior, polycythemia vera, and myelodysplastic syndromes. These codes are used to classify and report diagnoses where the behavior of the neoplasm (tumor) is uncertain or unspecified, and for conditions like polycythemia vera and myelodysplastic syndromes. The codes provide a way to track these conditions, inform treatment strategies, and aid in epidemiological studies.

Key Usage Points:

  • •Always code to the highest level of specificity.
  • •Use additional codes to identify any associated conditions or complications.
  • •For neoplasms of uncertain behavior, the site of the neoplasm should be identified.
  • •Polycythemia vera and myelodysplastic syndromes have specific codes within this range.
  • •Follow the alphabetic index and tabular list for correct code selection.

Coding Guidelines

When to Use:

  • ✓When the behavior of the neoplasm is uncertain after diagnostic workup.
  • ✓When a patient is diagnosed with polycythemia vera.
  • ✓When a patient is diagnosed with a myelodysplastic syndrome.
  • ✓When the site of the neoplasm is known but its behavior is uncertain.
  • ✓When the neoplasm is stated as uncertain, possible, probable, suspected, likely, questionable, or rule out.

When NOT to Use:

  • ✗When the behavior of the neoplasm is confirmed as benign or malignant.
  • ✗When the site of the neoplasm is not known.
  • ✗When the patient has a history of neoplasm, but no current disease.
  • ✗When the patient has a family history of neoplasm, but no personal diagnosis.
  • ✗When the patient has a neoplasm-related syndrome but not a neoplasm.

Code Exclusions

Always verify exclusions in the Tabular List of the ICD-10-CM.

Documentation Requirements

Documentation for codes in the D37-D48 range should clearly state the diagnosis, the behavior of the neoplasm if known, and the site of the neoplasm. For polycythemia vera and myelodysplastic syndromes, the specific condition should be documented.

Clinical Information:

  • •Specific diagnosis
  • •Behavior of the neoplasm
  • •Site of the neoplasm
  • •Presence of any associated conditions or complications
  • •Results of any diagnostic tests

Supporting Evidence:

  • •Pathology reports
  • •Imaging reports
  • •Laboratory test results
  • •Clinical notes
Good Documentation Example:

Patient diagnosed with neoplasm of uncertain behavior of the liver.

Poor Documentation Example:

Patient has a liver neoplasm.

Common Documentation Errors:

  • âš Not specifying the behavior of the neoplasm
  • âš Not specifying the site of the neoplasm
  • âš Not including associated conditions or complications
  • âš Not using the highest level of specificity

Range Statistics

13
Total Codes
112
Billable
Complexity:
Medium
Primary Use:Clinical Documentation
Chapter:3

Coding Complexity

Medium
Complexity Rating

The complexity of coding in this range is considered medium. This is due to the need to determine the behavior and site of the neoplasm, identify any associated conditions or complications, follow the alphabetic index and tabular list for correct code selection, and code to the highest level of specificity.

Key Factors:
  • â–¸Determining the behavior of the neoplasm
  • â–¸Identifying the site of the neoplasm
  • â–¸Identifying any associated conditions or complications
  • â–¸Following the alphabetic index and tabular list for correct code selection
  • â–¸Coding to the highest level of specificity

Specialty Focus

These codes are primarily used by oncologists, hematologists, and pathologists. They are also used by general practitioners and internists when a patient presents with a neoplasm of uncertain behavior or a condition like polycythemia vera or a myelodysplastic syndrome.

Primary Specialties:
Oncology
40%
Hematology
30%
Pathology
20%
Clinical Scenarios:
  • • A patient presents with a liver neoplasm of uncertain behavior.
  • • A patient is diagnosed with polycythemia vera.
  • • A patient has a neoplasm of uncertain behavior in the pancreas.
  • • A patient is diagnosed with a myelodysplastic syndrome.
  • • A patient has a neoplasm of uncertain behavior in the lung.

Resources & References

Resources for these codes include the ICD-10-CM Official Guidelines for Coding and Reporting, the American Health Information Management Association (AHIMA), and the American Academy of Professional Coders (AAPC). These resources provide coding guidelines, clinical documentation tips, and educational materials.

Official Guidelines:

  • ICD-10-CM Official Guidelines for Coding and Reporting
  • AHIMA Coding Guidelines
  • AAPC Coding Guidelines

Clinical References:

  • National Cancer Institute
  • American Society of Hematology

Educational Materials:

  • AHIMA ICD-10 Training
  • AAPC ICD-10 Training

Frequently Asked Questions

What is the difference between a neoplasm of uncertain behavior and a neoplasm of unspecified behavior?

A neoplasm of uncertain behavior is one where the behavior is not specified as either benign or malignant after diagnostic workup. A neoplasm of unspecified behavior is one where the behavior is not stated in the medical record.