E70-E88
Medium Complexity

Metabolic disorders

Primary Specialty: Endocrinology
Last Updated: 2025-09-09

ICD-10 Codes (200)

183 billable
12 category headers
E71
Billable
Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
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E71.0
Billable
Maple-syrup-urine disease
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E71.1
Billable
Other disorders of branched-chain amino-acid metabolism
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E71.11
Billable
Branched-chain organic acidurias
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E71.110
Billable
Isovaleric acidemia
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E71.111
Billable
3-methylglutaconic aciduria
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E71.118
Billable
Other branched-chain organic acidurias
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E71.12
Billable
Disorders of propionate metabolism
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E71.120
Billable
Methylmalonic acidemia
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E71.121
Billable
Propionic acidemia
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E71.128
Billable
Other disorders of propionate metabolism
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E71.19
Billable
Other disorders of branched-chain amino-acid metabolism
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E71.2
Billable
Disorder of branched-chain amino-acid metabolism, unspecified
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E71.3
Billable
Disorders of fatty-acid metabolism
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E71.30
Billable
Disorder of fatty-acid metabolism, unspecified
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E71.31
Billable
Disorders of fatty-acid oxidation
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E71.310
Billable
Long chain/very long chain acyl CoA dehydrogenase deficiency
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E71.311
Billable
Medium chain acyl CoA dehydrogenase deficiency
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E71.312
Billable
Short chain acyl CoA dehydrogenase deficiency
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E71.313
Billable
Glutaric aciduria type II
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E71.314
Billable
Muscle carnitine palmitoyltransferase deficiency
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E71.318
Billable
Other disorders of fatty-acid oxidation
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E71.32
Billable
Disorders of ketone metabolism
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E71.39
Billable
Other disorders of fatty-acid metabolism
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E71.4
Billable
Disorders of carnitine metabolism
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E71.40
Billable
Disorder of carnitine metabolism, unspecified
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E71.41
Billable
Primary carnitine deficiency
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E71.42
Billable
Carnitine deficiency due to inborn errors of metabolism
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E71.43
Billable
Iatrogenic carnitine deficiency
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E71.44
Billable
Other secondary carnitine deficiency
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E71.440
Billable
Ruvalcaba-Myhre-Smith syndrome
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E71.448
Billable
Other secondary carnitine deficiency
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E71.5
Billable
Peroxisomal disorders
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E71.50
Billable
Peroxisomal disorder, unspecified
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E71.51
Billable
Disorders of peroxisome biogenesis
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E71.510
Billable
Zellweger syndrome
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E71.511
Billable
Neonatal adrenoleukodystrophy
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E71.518
Billable
Other disorders of peroxisome biogenesis
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E71.52
Billable
X-linked adrenoleukodystrophy
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E71.520
Billable
Childhood cerebral X-linked adrenoleukodystrophy
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E71.521
Billable
Adolescent X-linked adrenoleukodystrophy
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E71.522
Billable
Adrenomyeloneuropathy
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E71.528
Billable
Other X-linked adrenoleukodystrophy
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E71.529
Billable
X-linked adrenoleukodystrophy, unspecified type
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E71.53
Billable
Other group 2 peroxisomal disorders
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E71.54
Billable
Other peroxisomal disorders
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E71.540
Billable
Rhizomelic chondrodysplasia punctata
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E71.541
Billable
Zellweger-like syndrome
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E71.542
Billable
Other group 3 peroxisomal disorders
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E71.548
Billable
Other peroxisomal disorders
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E72
Billable
Other disorders of amino-acid metabolism
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E72.0
Billable
Disorders of amino-acid transport
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E72.00
Billable
Disorders of amino-acid transport, unspecified
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E72.01
Billable
Cystinuria
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E72.02
Billable
Hartnup's disease
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E72.03
Billable
Lowe's syndrome
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E72.04
Billable
Cystinosis
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E72.09
Billable
Other disorders of amino-acid transport
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E72.1
Billable
Disorders of sulfur-bearing amino-acid metabolism
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E72.10
Billable
Disorders of sulfur-bearing amino-acid metabolism, unspecified
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E72.11
Billable
Homocystinuria
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E72.12
Billable
Methylenetetrahydrofolate reductase deficiency
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E72.19
Billable
Other disorders of sulfur-bearing amino-acid metabolism
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E72.2
Billable
Disorders of urea cycle metabolism
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E72.20
Billable
Disorder of urea cycle metabolism, unspecified
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E72.21
Billable
Argininemia
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E72.22
Billable
Arginosuccinic aciduria
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E72.23
Billable
Citrullinemia
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E72.29
Billable
Other disorders of urea cycle metabolism
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E72.3
Billable
Disorders of lysine and hydroxylysine metabolism
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E72.4
Billable
Disorders of ornithine metabolism
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E72.5
Billable
Disorders of glycine metabolism
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E72.50
Billable
Disorder of glycine metabolism, unspecified
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E72.51
Billable
Non-ketotic hyperglycinemia
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E72.52
Billable
Trimethylaminuria
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E72.53
Billable
Primary hyperoxaluria
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E72.59
Billable
Other disorders of glycine metabolism
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E72.8
Billable
Other specified disorders of amino-acid metabolism
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E72.81
Billable
Disorders of gamma aminobutyric acid metabolism
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E72.89
Billable
Other specified disorders of amino-acid metabolism
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E72.9
Billable
Disorder of amino-acid metabolism, unspecified
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E73
Billable
Lactose intolerance
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E73.0
Billable
Congenital lactase deficiency
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E73.1
Billable
Secondary lactase deficiency
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E73.8
Billable
Other lactose intolerance
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E73.9
Billable
Lactose intolerance, unspecified
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E74
Billable
Other disorders of carbohydrate metabolism
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E74.0
Billable
Glycogen storage disease
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E74.00
Billable
Glycogen storage disease, unspecified
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E74.01
Billable
von Gierke disease
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E74.02
Billable
Pompe disease
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E74.03
Billable
Cori disease
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E74.04
Billable
McArdle disease
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E74.05
Billable
Lysosome-associated membrane protein 2 [LAMP2] deficiency
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E74.09
Billable
Other glycogen storage disease
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E74.1
Billable
Disorders of fructose metabolism
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E74.10
Billable
Disorder of fructose metabolism, unspecified
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E74.11
Billable
Essential fructosuria
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E74.12
Billable
Hereditary fructose intolerance
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E74.19
Billable
Other disorders of fructose metabolism
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E74.2
Billable
Disorders of galactose metabolism
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E74.20
Billable
Disorders of galactose metabolism, unspecified
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E74.21
Billable
Galactosemia
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E74.29
Billable
Other disorders of galactose metabolism
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E74.3
Billable
Other disorders of intestinal carbohydrate absorption
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E74.31
Billable
Sucrase-isomaltase deficiency
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E74.39
Billable
Other disorders of intestinal carbohydrate absorption
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E74.4
Billable
Disorders of pyruvate metabolism and gluconeogenesis
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E74.8
Billable
Other specified disorders of carbohydrate metabolism
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E74.81
Billable
Disorders of glucose transport, not elsewhere classified
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E74.810
Billable
Glucose transporter protein type 1 deficiency
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E74.818
Billable
Other disorders of glucose transport
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E74.819
Billable
Disorders of glucose transport, unspecified
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E74.82
Billable
Disorders of citrate metabolism
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E74.820
Billable
SLC13A5 Citrate Transporter Disorder
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E74.829
Billable
Other disorders of citrate metabolism
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E74.89
Billable
Other specified disorders of carbohydrate metabolism
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E74.9
Billable
Disorder of carbohydrate metabolism, unspecified
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E75
Disorders of sphingolipid metabolism and other lipid storage disorders
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E75.0
GM2 gangliosidosis
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E75.00
Billable
GM2 gangliosidosis, unspecified
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E75.01
Billable
Sandhoff disease
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E75.02
Billable
Tay-Sachs disease
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E75.09
Billable
Other GM2 gangliosidosis
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E75.1
Other and unspecified gangliosidosis
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E75.10
Billable
Unspecified gangliosidosis
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E75.11
Billable
Mucolipidosis IV
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E75.19
Billable
Other gangliosidosis
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E75.2
Other sphingolipidosis
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E75.21
Billable
Fabry (-Anderson) disease
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E75.22
Billable
Gaucher disease
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E75.23
Billable
Krabbe disease
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E75.24
Niemann-Pick disease
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E75.240
Billable
Niemann-Pick disease type A
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E75.241
Billable
Niemann-Pick disease type B
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E75.242
Billable
Niemann-Pick disease type C
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E75.243
Billable
Niemann-Pick disease type D
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E75.244
Billable
Niemann-Pick disease type A/B
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E75.248
Billable
Other Niemann-Pick disease
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E75.249
Billable
Niemann-Pick disease, unspecified
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E75.25
Billable
Metachromatic leukodystrophy
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E75.26
Billable
Sulfatase deficiency
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E75.27
Billable
Pelizaeus-Merzbacher disease
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E75.28
Billable
Canavan disease
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E75.29
Billable
Other sphingolipidosis
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E75.3
Billable
Sphingolipidosis, unspecified
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E75.4
Billable
Neuronal ceroid lipofuscinosis
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E75.5
Billable
Other lipid storage disorders
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E75.6
Billable
Lipid storage disorder, unspecified
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E76
Disorders of glycosaminoglycan metabolism
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E76.0
Mucopolysaccharidosis, type I
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E76.01
Billable
Hurler's syndrome
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E76.02
Billable
Hurler-Scheie syndrome
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E76.03
Billable
Scheie's syndrome
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E76.1
Billable
Mucopolysaccharidosis, type II
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E76.2
Other mucopolysaccharidoses
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E76.21
Morquio mucopolysaccharidoses
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E76.210
Billable
Morquio A mucopolysaccharidoses
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E76.211
Billable
Morquio B mucopolysaccharidoses
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E76.219
Billable
Morquio mucopolysaccharidoses, unspecified
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E76.22
Billable
Sanfilippo mucopolysaccharidoses
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E76.29
Billable
Other mucopolysaccharidoses
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E76.3
Billable
Mucopolysaccharidosis, unspecified
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E76.8
Billable
Other disorders of glucosaminoglycan metabolism
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E76.9
Billable
Glucosaminoglycan metabolism disorder, unspecified
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E77
Disorders of glycoprotein metabolism
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E77.0
Billable
Defects in post-translational modification of lysosomal enzymes
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E77.1
Billable
Defects in glycoprotein degradation
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E77.8
Billable
Other disorders of glycoprotein metabolism
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E77.9
Billable
Disorder of glycoprotein metabolism, unspecified
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E78
Disorders of lipoprotein metabolism and other lipidemias
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E78.0
Pure hypercholesterolemia
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E78.00
Billable
Pure hypercholesterolemia, unspecified
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E78.01
Billable
Familial hypercholesterolemia
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E78.1
Billable
Pure hyperglyceridemia
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E78.2
Billable
Mixed hyperlipidemia
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E78.3
Billable
Hyperchylomicronemia
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E78.4
Other hyperlipidemia
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E78.41
Billable
Elevated Lipoprotein(a)
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E78.49
Billable
Other hyperlipidemia
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E78.5
Billable
Hyperlipidemia, unspecified
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E78.6
Billable
Lipoprotein deficiency
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E78.7
Disorders of bile acid and cholesterol metabolism
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E78.70
Billable
Disorder of bile acid and cholesterol metabolism, unspecified
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E78.71
Billable
Barth syndrome
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E78.72
Billable
Smith-Lemli-Opitz syndrome
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E78.79
Billable
Other disorders of bile acid and cholesterol metabolism
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E78.8
Other disorders of lipoprotein metabolism
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E78.81
Billable
Lipoid dermatoarthritis
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E78.89
Billable
Other lipoprotein metabolism disorders
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E78.9
Billable
Disorder of lipoprotein metabolism, unspecified
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E79
Disorders of purine and pyrimidine metabolism
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E79.0
Billable
Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
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E79.1
Billable
Lesch-Nyhan syndrome
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E79.2
Billable
Myoadenylate deaminase deficiency
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E79.8
Other disorders of purine and pyrimidine metabolism
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E79.81
Billable
Aicardi-Goutières syndrome
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E79.82
Billable
Hereditary xanthinuria
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E79.89
Billable
Other specified disorders of purine and pyrimidine metabolism
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E79.9
Billable
Disorder of purine and pyrimidine metabolism, unspecified
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Updates & Changes

FY 2026 Updates

Current Year

Deleted Codes

No codes deleted in this range for FY 2026

No significant changes for FY 2026

This range maintains stability with current coding practices

Historical Changes

  • FY 2025: Routine maintenance updates with minor terminology clarifications
  • FY 2024: Enhanced specificity requirements for certain code ranges
  • FY 2023: Updated documentation guidelines for improved clarity

Upcoming Changes

  • Proposed updates pending review by Coordination and Maintenance Committee
  • Under consideration: Enhanced digital health integration codes

Implementation Guidance

  • Review all FY 2026 updates for E70-E88 codes before implementation
  • Always verify the most current codes in the ICD-10-CM manual
  • Ensure clinical documentation supports the selected diagnosis codes
  • +3 more guidance items...

Range Overview

high priority

The E08-E13 range in ICD-10 is dedicated to Diabetes Mellitus, a group of metabolic disorders characterized by high blood sugar levels over a prolonged period. This range includes codes for different types of diabetes, such as Type 1, Type 2, gestational, and drug-induced diabetes. It also covers codes for various complications and manifestations related to diabetes, such as diabetic retinopathy, nephropathy, and neuropathy.

Key Usage Points:

  • Always specify the type of diabetes (Type 1, Type 2, gestational, etc.) in the patient's medical record.
  • Include the control status (controlled or uncontrolled) when coding for diabetes.
  • Use combination codes to accurately represent diabetes with associated complications.
  • For drug-induced diabetes, specify the drug causing the condition.
  • In case of gestational diabetes, include the trimester in the documentation.

Coding Guidelines

When to Use:

  • When a patient is diagnosed with any type of diabetes.
  • When a patient with diabetes presents with complications such as retinopathy, nephropathy, or neuropathy.
  • When a patient's diabetes is induced by a specific drug.
  • When a pregnant woman is diagnosed with gestational diabetes.

When NOT to Use:

  • When a patient has prediabetes or impaired glucose tolerance, these conditions have their own specific codes.
  • When a patient has secondary diabetes caused by another condition such as Cushing's syndrome or cystic fibrosis.
  • When a patient has neonatal diabetes, which is coded separately.
  • When a patient has transient diabetes.

Code Exclusions

Always cross-verify the exclusions with the patient's clinical information to ensure accurate coding.

Documentation Requirements

Accurate documentation is crucial for coding diabetes. It should clearly specify the type of diabetes, control status, and any associated complications.

Clinical Information:

  • Type of diabetes
  • Control status of diabetes
  • Presence of any complications
  • Cause of drug-induced diabetes, if applicable
  • Trimester for gestational diabetes, if applicable

Supporting Evidence:

  • Laboratory test results confirming diabetes
  • Medical history and physical examination notes
  • Medication records, if diabetes is drug-induced
  • Obstetric records for gestational diabetes
Good Documentation Example:

Patient diagnosed with Type 2 Diabetes, uncontrolled, with moderate nonproliferative diabetic retinopathy.

Poor Documentation Example:

Patient has diabetes.

Common Documentation Errors:

  • Not specifying the type of diabetes
  • Not including the control status
  • Not documenting associated complications
  • Not specifying the drug in case of drug-induced diabetes

Range Statistics

Total Codes
183
Billable
Complexity:
Medium
Primary Use:Clinical Documentation
Chapter:4

Coding Complexity

Medium
Complexity Rating

The complexity of coding diabetes lies in the need to accurately identify the type of diabetes, control status, and any associated complications. Additionally, coding for drug-induced and gestational diabetes requires specific information.

Key Factors:
  • Differentiating between types of diabetes
  • Identifying and coding for associated complications
  • Determining control status
  • Identifying drug-induced diabetes
  • Coding for gestational diabetes with trimester

Specialty Focus

The E08-E13 range is most commonly used by endocrinologists, primary care physicians, and obstetricians.

Primary Specialties:
Endocrinology
50%
Primary Care
30%
Obstetrics
20%
Clinical Scenarios:
  • A patient newly diagnosed with Type 1 Diabetes
  • A patient with Type 2 Diabetes presenting with diabetic nephropathy
  • A patient with gestational diabetes in her second trimester
  • A patient with diabetes induced by steroid medication
  • A patient with uncontrolled diabetes presenting with diabetic neuropathy

Resources & References

Several resources provide guidance on coding for diabetes, including the official ICD-10 guidelines, clinical reference materials, and educational resources.

Official Guidelines:

  • ICD-10-CM Official Guidelines for Coding and Reporting
  • American Diabetes Association Clinical Practice Recommendations
  • World Health Organization ICD-10 Guidelines

Clinical References:

  • Clinical Diabetes Journal
  • Diabetes Care Journal

Educational Materials:

  • American Health Information Management Association (AHIMA) ICD-10 training materials
  • American Academy of Professional Coders (AAPC) ICD-10 training materials

Frequently Asked Questions

How do I code for a patient with Type 2 Diabetes and diabetic retinopathy?

Use a combination code that includes both Type 2 Diabetes and diabetic retinopathy. For example, E11.3x for Type 2 Diabetes with ophthalmic complications.