T36-T50
Medium Complexity

Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances

Primary Specialty: Emergency Medicine
Last Updated: 2025-09-09

ICD-10 Codes (200)

0 billable
195 category headers
T37
Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics
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T37.0
Poisoning by, adverse effect of and underdosing of sulfonamides
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T37.1
Poisoning by, adverse effect of and underdosing of antimycobacterial drugs
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T37.2
Poisoning by, adverse effect of and underdosing of antimalarials and drugs acting on other blood protozoa
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T37.3
Poisoning by, adverse effect of and underdosing of other antiprotozoal drugs
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T37.4
Poisoning by, adverse effect of and underdosing of anthelminthics
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T37.5
Poisoning by, adverse effect of and underdosing of antiviral drugs
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T37.8
Poisoning by, adverse effect of and underdosing of other specified systemic anti-infectives and antiparasitics
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T37.9
Poisoning by, adverse effect of and underdosing of unspecified systemic anti-infective and antiparasitics
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T37.91
Poisoning by unspecified systemic anti-infective and antiparasitics, accidental (unintentional)
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T37.92
Poisoning by unspecified systemic anti-infective and antiparasitics, intentional self-harm
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T37.93
Poisoning by unspecified systemic anti-infective and antiparasitics, assault
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T37.94
Poisoning by unspecified systemic anti-infective and antiparasitics, undetermined
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T37.95
Adverse effect of unspecified systemic anti-infective and antiparasitic
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T37.96
Underdosing of unspecified systemic anti-infectives and antiparasitics
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T38
Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified
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T38.0
Poisoning by, adverse effect of and underdosing of glucocorticoids and synthetic analogues
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T38.1
Poisoning by, adverse effect of and underdosing of thyroid hormones and substitutes
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T38.2
Poisoning by, adverse effect of and underdosing of antithyroid drugs
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T38.3
Poisoning by, adverse effect of and underdosing of insulin and oral hypoglycemic [antidiabetic] drugs
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T38.4
Poisoning by, adverse effect of and underdosing of oral contraceptives
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T38.5
Poisoning by, adverse effect of and underdosing of other estrogens and progestogens
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T38.6
Poisoning by, adverse effect of and underdosing of antigonadotrophins, antiestrogens, antiandrogens, not elsewhere classified
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T38.7
Poisoning by, adverse effect of and underdosing of androgens and anabolic congeners
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T38.8
Poisoning by, adverse effect of and underdosing of other and unspecified hormones and synthetic substitutes
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T38.80
Poisoning by, adverse effect of and underdosing of unspecified hormones and synthetic substitutes
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T38.801
Poisoning by unspecified hormones and synthetic substitutes, accidental (unintentional)
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T38.802
Poisoning by unspecified hormones and synthetic substitutes, intentional self-harm
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T38.803
Poisoning by unspecified hormones and synthetic substitutes, assault
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T38.804
Poisoning by unspecified hormones and synthetic substitutes, undetermined
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T38.805
Adverse effect of unspecified hormones and synthetic substitutes
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T38.806
Underdosing of unspecified hormones and synthetic substitutes
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T38.81
Poisoning by, adverse effect of and underdosing of anterior pituitary [adenohypophyseal] hormones
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T38.811
Poisoning by anterior pituitary [adenohypophyseal] hormones, accidental (unintentional)
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T38.812
Poisoning by anterior pituitary [adenohypophyseal] hormones, intentional self-harm
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T38.813
Poisoning by anterior pituitary [adenohypophyseal] hormones, assault
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T38.814
Poisoning by anterior pituitary [adenohypophyseal] hormones, undetermined
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T38.815
Adverse effect of anterior pituitary [adenohypophyseal] hormones
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T38.816
Underdosing of anterior pituitary [adenohypophyseal] hormones
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T38.89
Poisoning by, adverse effect of and underdosing of other hormones and synthetic substitutes
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T38.891
Poisoning by other hormones and synthetic substitutes, accidental (unintentional)
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T38.892
Poisoning by other hormones and synthetic substitutes, intentional self-harm
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T38.893
Poisoning by other hormones and synthetic substitutes, assault
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T38.894
Poisoning by other hormones and synthetic substitutes, undetermined
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T38.895
Adverse effect of other hormones and synthetic substitutes
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T38.896
Underdosing of other hormones and synthetic substitutes
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T38.9
Poisoning by, adverse effect of and underdosing of other and unspecified hormone antagonists
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T38.90
Poisoning by, adverse effect of and underdosing of unspecified hormone antagonists
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T38.901
Poisoning by unspecified hormone antagonists, accidental (unintentional)
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T38.902
Poisoning by unspecified hormone antagonists, intentional self-harm
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T38.903
Poisoning by unspecified hormone antagonists, assault
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T38.904
Poisoning by unspecified hormone antagonists, undetermined
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T38.905
Adverse effect of unspecified hormone antagonists
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T38.906
Underdosing of unspecified hormone antagonists
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T38.99
Poisoning by, adverse effect of and underdosing of other hormone antagonists
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T38.991
Poisoning by other hormone antagonists, accidental (unintentional)
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T38.992
Poisoning by other hormone antagonists, intentional self-harm
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T38.993
Poisoning by other hormone antagonists, assault
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T38.994
Poisoning by other hormone antagonists, undetermined
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T38.995
Adverse effect of other hormone antagonists
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T38.996
Underdosing of other hormone antagonists
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T39
Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics
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T39.0
Poisoning by, adverse effect of and underdosing of salicylates
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T39.01
Poisoning by, adverse effect of and underdosing of aspirin
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T39.011
Poisoning by aspirin, accidental (unintentional)
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T39.012
Poisoning by aspirin, intentional self-harm
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T39.013
Poisoning by aspirin, assault
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T39.014
Poisoning by aspirin, undetermined
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T39.015
Adverse effect of aspirin
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T39.016
Underdosing of aspirin
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T39.09
Poisoning by, adverse effect of and underdosing of other salicylates
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T39.091
Poisoning by salicylates, accidental (unintentional)
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T39.092
Poisoning by salicylates, intentional self-harm
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T39.093
Poisoning by salicylates, assault
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T39.094
Poisoning by salicylates, undetermined
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T39.095
Adverse effect of salicylates
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T39.096
Underdosing of salicylates
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T39.1
Poisoning by, adverse effect of and underdosing of 4-Aminophenol derivatives
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T39.2
Poisoning by, adverse effect of and underdosing of pyrazolone derivatives
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T39.3
Poisoning by, adverse effect of and underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]
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T39.31
Poisoning by, adverse effect of and underdosing of propionic acid derivatives
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T39.311
Poisoning by propionic acid derivatives, accidental (unintentional)
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T39.312
Poisoning by propionic acid derivatives, intentional self-harm
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T39.313
Poisoning by propionic acid derivatives, assault
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T39.314
Poisoning by propionic acid derivatives, undetermined
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T39.315
Adverse effect of propionic acid derivatives
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T39.316
Underdosing of propionic acid derivatives
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T39.39
Poisoning by, adverse effect of and underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]
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T39.391
Poisoning by other nonsteroidal anti-inflammatory drugs [NSAID], accidental (unintentional)
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T39.392
Poisoning by other nonsteroidal anti-inflammatory drugs [NSAID], intentional self-harm
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T39.393
Poisoning by other nonsteroidal anti-inflammatory drugs [NSAID], assault
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T39.394
Poisoning by other nonsteroidal anti-inflammatory drugs [NSAID], undetermined
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T39.395
Adverse effect of other nonsteroidal anti-inflammatory drugs [NSAID]
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T39.396
Underdosing of other nonsteroidal anti-inflammatory drugs [NSAID]
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T39.4
Poisoning by, adverse effect of and underdosing of antirheumatics, not elsewhere classified
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T39.8
Poisoning by, adverse effect of and underdosing of other nonopioid analgesics and antipyretics, not elsewhere classified
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T39.9
Poisoning by, adverse effect of and underdosing of unspecified nonopioid analgesic, antipyretic and antirheumatic
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T39.91
Poisoning by unspecified nonopioid analgesic, antipyretic and antirheumatic, accidental (unintentional)
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T39.92
Poisoning by unspecified nonopioid analgesic, antipyretic and antirheumatic, intentional self-harm
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T39.93
Poisoning by unspecified nonopioid analgesic, antipyretic and antirheumatic, assault
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T39.94
Poisoning by unspecified nonopioid analgesic, antipyretic and antirheumatic, undetermined
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T39.95
Adverse effect of unspecified nonopioid analgesic, antipyretic and antirheumatic
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T39.96
Underdosing of unspecified nonopioid analgesic, antipyretic and antirheumatic
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T40
Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens]
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T40.0
Poisoning by, adverse effect of and underdosing of opium
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T40.1
Poisoning by and adverse effect of heroin
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T40.2
Poisoning by, adverse effect of and underdosing of other opioids
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T40.3
Poisoning by, adverse effect of and underdosing of methadone
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T40.4
Poisoning by, adverse effect of and underdosing of other synthetic narcotics
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T40.41
Poisoning by, adverse effect of and underdosing of fentanyl or fentanyl analogs
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T40.411
Poisoning by fentanyl or fentanyl analogs, accidental (unintentional)
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T40.412
Poisoning by fentanyl or fentanyl analogs, intentional self-harm
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T40.413
Poisoning by fentanyl or fentanyl analogs, assault
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T40.414
Poisoning by fentanyl or fentanyl analogs, undetermined
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T40.415
Adverse effect of fentanyl or fentanyl analogs
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T40.416
Underdosing of fentanyl or fentanyl analogs
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T40.42
Poisoning by, adverse effect of and underdosing of tramadol
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T40.421
Poisoning by tramadol, accidental (unintentional)
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T40.422
Poisoning by tramadol, intentional self-harm
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T40.423
Poisoning by tramadol, assault
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T40.424
Poisoning by tramadol, undetermined
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T40.425
Adverse effect of tramadol
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T40.426
Underdosing of tramadol
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T40.49
Poisoning by, adverse effect of and underdosing of other synthetic narcotics
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T40.491
Poisoning by other synthetic narcotics, accidental (unintentional)
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T40.492
Poisoning by other synthetic narcotics, intentional self-harm
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T40.493
Poisoning by other synthetic narcotics, assault
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T40.494
Poisoning by other synthetic narcotics, undetermined
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T40.495
Adverse effect of other synthetic narcotics
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T40.496
Underdosing of other synthetic narcotics
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T40.5
Poisoning by, adverse effect of and underdosing of cocaine
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T40.6
Poisoning by, adverse effect of and underdosing of other and unspecified narcotics
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T40.60
Poisoning by, adverse effect of and underdosing of unspecified narcotics
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T40.601
Poisoning by unspecified narcotics, accidental (unintentional)
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T40.602
Poisoning by unspecified narcotics, intentional self-harm
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T40.603
Poisoning by unspecified narcotics, assault
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T40.604
Poisoning by unspecified narcotics, undetermined
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T40.605
Adverse effect of unspecified narcotics
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T40.606
Underdosing of unspecified narcotics
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T40.69
Poisoning by, adverse effect of and underdosing of other narcotics
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T40.691
Poisoning by other narcotics, accidental (unintentional)
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T40.692
Poisoning by other narcotics, intentional self-harm
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T40.693
Poisoning by other narcotics, assault
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T40.694
Poisoning by other narcotics, undetermined
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T40.695
Adverse effect of other narcotics
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T40.696
Underdosing of other narcotics
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T40.7
Poisoning by, adverse effect of and underdosing of cannabis (derivatives)
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T40.71
Poisoning by, adverse effect of and underdosing of cannabis (derivatives)
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T40.711
Poisoning by cannabis, accidental (unintentional)
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T40.712
Poisoning by cannabis, intentional self-harm
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T40.713
Poisoning by cannabis, assault
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T40.714
Poisoning by cannabis, undetermined
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T40.715
Adverse effect of cannabis
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T40.716
Underdosing of cannabis
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T40.72
Poisoning by, adverse effect of and underdosing of synthetic cannabinoids
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T40.721
Poisoning by synthetic cannabinoids, accidental (unintentional)
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T40.722
Poisoning by synthetic cannabinoids, intentional self-harm
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T40.723
Poisoning by synthetic cannabinoids, assault
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T40.724
Poisoning by synthetic cannabinoids, undetermined
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T40.725
Adverse effect of synthetic cannabinoids
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T40.726
Underdosing of synthetic cannabinoids
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T40.8
Poisoning by and adverse effect of lysergide [LSD]
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T40.9
Poisoning by, adverse effect of and underdosing of other and unspecified psychodysleptics [hallucinogens]
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T40.90
Poisoning by, adverse effect of and underdosing of unspecified psychodysleptics [hallucinogens]
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T40.901
Poisoning by unspecified psychodysleptics [hallucinogens], accidental (unintentional)
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T40.902
Poisoning by unspecified psychodysleptics [hallucinogens], intentional self-harm
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T40.903
Poisoning by unspecified psychodysleptics [hallucinogens], assault
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T40.904
Poisoning by unspecified psychodysleptics [hallucinogens], undetermined
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T40.905
Adverse effect of unspecified psychodysleptics [hallucinogens]
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T40.906
Underdosing of unspecified psychodysleptics [hallucinogens]
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T40.99
Poisoning by, adverse effect of and underdosing of other psychodysleptics [hallucinogens]
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T40.991
Poisoning by other psychodysleptics [hallucinogens], accidental (unintentional)
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T40.992
Poisoning by other psychodysleptics [hallucinogens], intentional self-harm
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T40.993
Poisoning by other psychodysleptics [hallucinogens], assault
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T40.994
Poisoning by other psychodysleptics [hallucinogens], undetermined
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T40.995
Adverse effect of other psychodysleptics [hallucinogens]
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T40.996
Underdosing of other psychodysleptics [hallucinogens]
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T41
Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases
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T41.0
Poisoning by, adverse effect of and underdosing of inhaled anesthetics
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T41.1
Poisoning by, adverse effect of and underdosing of intravenous anesthetics
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T41.2
Poisoning by, adverse effect of and underdosing of other and unspecified general anesthetics
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T41.20
Poisoning by, adverse effect of and underdosing of unspecified general anesthetics
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T41.201
Poisoning by unspecified general anesthetics, accidental (unintentional)
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T41.202
Poisoning by unspecified general anesthetics, intentional self-harm
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T41.203
Poisoning by unspecified general anesthetics, assault
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T41.204
Poisoning by unspecified general anesthetics, undetermined
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T41.205
Adverse effect of unspecified general anesthetics
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T41.206
Underdosing of unspecified general anesthetics
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T41.29
Poisoning by, adverse effect of and underdosing of other general anesthetics
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T41.291
Poisoning by other general anesthetics, accidental (unintentional)
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T41.292
Poisoning by other general anesthetics, intentional self-harm
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T41.293
Poisoning by other general anesthetics, assault
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T41.294
Poisoning by other general anesthetics, undetermined
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T41.295
Adverse effect of other general anesthetics
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T41.296
Underdosing of other general anesthetics
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T41.3
Poisoning by, adverse effect of and underdosing of local anesthetics
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T41.4
Poisoning by, adverse effect of and underdosing of unspecified anesthetic
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T41.41
Poisoning by unspecified anesthetic, accidental (unintentional)
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T41.42
Poisoning by unspecified anesthetic, intentional self-harm
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T41.43
Poisoning by unspecified anesthetic, assault
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Updates & Changes

FY 2026 Updates

Current Year

New Codes (2)

T40.411A
Poisoning by fentanyl, accidental (unintentional), initial encounter
T40.491A
Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter

Revised Codes (1)

T40.2X1A
Poisoning by other opioids, accidental (unintentional) - updated to include synthetic opioid specifications

Deleted Codes

No codes deleted in this range for FY 2026

Historical Changes

  • •FY 2025: Routine maintenance updates with minor terminology clarifications
  • •FY 2024: Enhanced specificity requirements for certain code ranges
  • •FY 2023: Updated documentation guidelines for improved clarity

Upcoming Changes

  • •Proposed updates pending review by Coordination and Maintenance Committee
  • •Under consideration: Enhanced digital health integration codes

Implementation Guidance

  • •Review all FY 2026 updates for T36-T50 codes before implementation
  • •Always verify the most current codes in the ICD-10-CM manual
  • •Ensure clinical documentation supports the selected diagnosis codes
  • +3 more guidance items...

Range Overview

high priority

The ICD-10 code range T36-T50 is designed to capture incidents of poisoning, adverse effects, and underdosing of drugs, medicaments, and biological substances. This range is comprehensive, covering a wide array of substances, from antibiotics (T36) to hormones and their synthetic substitutes (T38), and even to narcotics and psychodysleptics (T40). These codes are used in a variety of clinical settings, from emergency departments to primary care, and are critical for tracking public health trends, billing, and research.

Key Usage Points:

  • •Always code for the most specific level of detail available, including the substance involved and the type of encounter.
  • •Remember to use additional codes to identify any associated withdrawal symptoms from drugs or substances.
  • •For underdosing, always assign a code explaining the reason from categories Z91.12-, Z91.13-, Z91.14-.
  • •In the case of poisoning, use additional code(s) for all manifestations of poisonings.
  • •For adverse effects, the nature of the adverse effect should be identified by use of codes from categories T78.4, T78.5, T80.5 and T88.6.

Coding Guidelines

When to Use:

  • ✓When a patient presents with symptoms due to accidental or intentional overdose of a medication.
  • ✓When a patient experiences an adverse effect from a medication as a result of correct use.
  • ✓When a patient has not taken enough of their prescribed medication, resulting in an underdose.
  • ✓When a patient presents with withdrawal symptoms from a substance.
  • ✓When a patient is seen for follow-up care after being treated for poisoning.

When NOT to Use:

  • ✗When a patient presents with symptoms that are not related to poisoning, adverse effects, or underdosing of a drug.
  • ✗When the patient's condition is due to drug abuse or dependence, not poisoning or underdosing.
  • ✗When the patient's condition is due to an allergic reaction, not an adverse effect.
  • ✗When the substance involved is not a drug, medicament, or biological substance.

Code Exclusions

Always verify exclusions by cross-referencing the patient's clinical documentation and the ICD-10-CM Official Guidelines for Coding and Reporting.

Documentation Requirements

Proper documentation for codes T36-T50 should include the specific substance involved, the type of encounter (initial, subsequent, sequela), and the intent (accidental, intentional self-harm, assault, undetermined). For underdosing, the reason should be documented. For adverse effects, the nature of the adverse effect should be identified.

Clinical Information:

  • •Specific substance involved
  • •Type of encounter
  • •Intent
  • •Reason for underdosing
  • •Nature of adverse effect

Supporting Evidence:

  • •Clinical notes
  • •Lab results
  • •Imaging studies
  • •Patient history
Good Documentation Example:

Patient presented with dizziness and nausea after accidentally taking double her prescribed dose of metoprolol. This is an initial encounter.

Poor Documentation Example:

Patient presented with dizziness and nausea.

Common Documentation Errors:

  • âš Not specifying the substance involved
  • âš Not indicating the type of encounter
  • âš Not documenting the intent
  • âš Not providing a reason for underdosing
  • âš Not identifying the nature of an adverse effect

Range Statistics

15
Total Codes
0
Billable
Complexity:
Medium
Primary Use:Clinical Documentation
Chapter:

Coding Complexity

Medium
Complexity Rating

The complexity of these codes is considered medium due to the need to accurately identify the specific substance involved, determine the type of encounter and intent, and identify the reason for underdosing or the nature of an adverse effect. This requires a thorough understanding of the clinical documentation and the ICD-10-CM Official Guidelines for Coding and Reporting.

Key Factors:
  • â–¸Identifying the specific substance involved
  • â–¸Determining the type of encounter
  • â–¸Determining the intent
  • â–¸Identifying the reason for underdosing
  • â–¸Identifying the nature of an adverse effect

Specialty Focus

These codes are used across many specialties, but are particularly prevalent in emergency medicine, primary care, and toxicology. They are used to document cases of poisoning, adverse effects, and underdosing, and are critical for tracking public health trends.

Primary Specialties:
Emergency Medicine
40%
Primary Care
30%
Toxicology
30%
Clinical Scenarios:
  • • A patient presents to the ER after accidentally overdosing on a medication.
  • • A patient experiences an adverse effect from a medication during a routine check-up.
  • • A patient has not taken enough of their prescribed medication, resulting in an underdose.
  • • A patient presents with withdrawal symptoms from a substance during a toxicology consultation.
  • • A patient is seen for follow-up care in primary care after being treated for poisoning in the ER.

Resources & References

There are several resources available for coding T36-T50, including the ICD-10-CM Official Guidelines for Coding and Reporting, clinical reference materials, and educational resources.

Official Guidelines:

  • ICD-10-CM Official Guidelines for Coding and Reporting
  • CDC ICD-10-CM Browser Tool
  • WHO ICD-10 Browser

Clinical References:

  • Clinical Pharmacology
  • UpToDate

Educational Materials:

  • AAPC ICD-10 Training
  • AHIMA ICD-10 Training

Frequently Asked Questions

How do I code for a patient who has taken too much of their medication?

You would use a code from the T36-T50 range, specifying the substance involved, the type of encounter (initial, subsequent, sequela), and the intent (accidental, intentional self-harm, assault, undetermined).