T51-T65
Medium Complexity

Toxic effects of substances chiefly nonmedicinal as to source

Primary Specialty: Emergency Medicine
Last Updated: 2025-09-09

ICD-10 Codes (200)

0 billable
188 category headers
T52
Toxic effect of organic solvents
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T52.0
Toxic effects of petroleum products
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T52.1
Toxic effects of benzene
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T52.2
Toxic effects of homologues of benzene
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T52.3
Toxic effects of glycols
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T52.4
Toxic effects of ketones
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T52.8
Toxic effects of other organic solvents
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T52.9
Toxic effects of unspecified organic solvent
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T52.91
Toxic effect of unspecified organic solvent, accidental (unintentional)
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T52.92
Toxic effect of unspecified organic solvent, intentional self-harm
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T52.93
Toxic effect of unspecified organic solvent, assault
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T52.94
Toxic effect of unspecified organic solvent, undetermined
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T53
Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbons
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T53.0
Toxic effects of carbon tetrachloride
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T53.1
Toxic effects of chloroform
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T53.2
Toxic effects of trichloroethylene
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T53.3
Toxic effects of tetrachloroethylene
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T53.4
Toxic effects of dichloromethane
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T53.5
Toxic effects of chlorofluorocarbons
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T53.6
Toxic effects of other halogen derivatives of aliphatic hydrocarbons
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T53.7
Toxic effects of other halogen derivatives of aromatic hydrocarbons
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T53.9
Toxic effects of unspecified halogen derivatives of aliphatic and aromatic hydrocarbons
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T53.91
Toxic effect of unspecified halogen derivatives of aliphatic and aromatic hydrocarbons, accidental (unintentional)
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T53.92
Toxic effect of unspecified halogen derivatives of aliphatic and aromatic hydrocarbons, intentional self-harm
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T53.93
Toxic effect of unspecified halogen derivatives of aliphatic and aromatic hydrocarbons, assault
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T53.94
Toxic effect of unspecified halogen derivatives of aliphatic and aromatic hydrocarbons, undetermined
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T54
Toxic effect of corrosive substances
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T54.0
Toxic effects of phenol and phenol homologues
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T54.1
Toxic effects of other corrosive organic compounds
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T54.2
Toxic effects of corrosive acids and acid-like substances
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T54.3
Toxic effects of corrosive alkalis and alkali-like substances
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T54.9
Toxic effects of unspecified corrosive substance
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T54.91
Toxic effect of unspecified corrosive substance, accidental (unintentional)
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T54.92
Toxic effect of unspecified corrosive substance, intentional self-harm
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T54.93
Toxic effect of unspecified corrosive substance, assault
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T54.94
Toxic effect of unspecified corrosive substance, undetermined
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T55
Toxic effect of soaps and detergents
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T55.0
Toxic effect of soaps
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T55.1
Toxic effect of detergents
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T56
Toxic effect of metals
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T56.0
Toxic effects of lead and its compounds
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T56.1
Toxic effects of mercury and its compounds
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T56.2
Toxic effects of chromium and its compounds
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T56.3
Toxic effects of cadmium and its compounds
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T56.4
Toxic effects of copper and its compounds
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T56.5
Toxic effects of zinc and its compounds
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T56.6
Toxic effects of tin and its compounds
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T56.7
Toxic effects of beryllium and its compounds
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T56.8
Toxic effects of other metals
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T56.81
Toxic effect of thallium
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T56.811
Toxic effect of thallium, accidental (unintentional)
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T56.812
Toxic effect of thallium, intentional self-harm
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T56.813
Toxic effect of thallium, assault
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T56.814
Toxic effect of thallium, undetermined
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T56.82
Toxic effect of gadolinium
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T56.821
Toxic effect of gadolinium, accidental (unintentional)
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T56.822
Toxic effect of gadolinium, intentional self-harm
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T56.823
Toxic effect of gadolinium, assault
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T56.824
Toxic effect of gadolinium, undetermined
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T56.89
Toxic effects of other metals
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T56.891
Toxic effect of other metals, accidental (unintentional)
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T56.892
Toxic effect of other metals, intentional self-harm
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T56.893
Toxic effect of other metals, assault
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T56.894
Toxic effect of other metals, undetermined
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T56.9
Toxic effects of unspecified metal
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T56.91
Toxic effect of unspecified metal, accidental (unintentional)
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T56.92
Toxic effect of unspecified metal, intentional self-harm
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T56.93
Toxic effect of unspecified metal, assault
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T56.94
Toxic effect of unspecified metal, undetermined
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T57
Toxic effect of other inorganic substances
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T57.0
Toxic effect of arsenic and its compounds
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T57.1
Toxic effect of phosphorus and its compounds
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T57.2
Toxic effect of manganese and its compounds
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T57.3
Toxic effect of hydrogen cyanide
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T57.8
Toxic effect of other specified inorganic substances
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T57.9
Toxic effect of unspecified inorganic substance
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T57.91
Toxic effect of unspecified inorganic substance, accidental (unintentional)
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T57.92
Toxic effect of unspecified inorganic substance, intentional self-harm
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T57.93
Toxic effect of unspecified inorganic substance, assault
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T57.94
Toxic effect of unspecified inorganic substance, undetermined
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T58
Toxic effect of carbon monoxide
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T58.0
Toxic effect of carbon monoxide from motor vehicle exhaust
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T58.01
Toxic effect of carbon monoxide from motor vehicle exhaust, accidental (unintentional)
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T58.02
Toxic effect of carbon monoxide from motor vehicle exhaust, intentional self-harm
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T58.03
Toxic effect of carbon monoxide from motor vehicle exhaust, assault
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T58.04
Toxic effect of carbon monoxide from motor vehicle exhaust, undetermined
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T58.1
Toxic effect of carbon monoxide from utility gas
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T58.11
Toxic effect of carbon monoxide from utility gas, accidental (unintentional)
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T58.12
Toxic effect of carbon monoxide from utility gas, intentional self-harm
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T58.13
Toxic effect of carbon monoxide from utility gas, assault
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T58.14
Toxic effect of carbon monoxide from utility gas, undetermined
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T58.2
Toxic effect of carbon monoxide from incomplete combustion of other domestic fuels
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T58.8
Toxic effect of carbon monoxide from other source
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T58.9
Toxic effect of carbon monoxide from unspecified source
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T58.91
Toxic effect of carbon monoxide from unspecified source, accidental (unintentional)
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T58.92
Toxic effect of carbon monoxide from unspecified source, intentional self-harm
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T58.93
Toxic effect of carbon monoxide from unspecified source, assault
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T58.94
Toxic effect of carbon monoxide from unspecified source, undetermined
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T59
Toxic effect of other gases, fumes and vapors
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T59.0
Toxic effect of nitrogen oxides
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T59.1
Toxic effect of sulfur dioxide
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T59.2
Toxic effect of formaldehyde
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T59.3
Toxic effect of lacrimogenic gas
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T59.4
Toxic effect of chlorine gas
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T59.5
Toxic effect of fluorine gas and hydrogen fluoride
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T59.6
Toxic effect of hydrogen sulfide
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T59.7
Toxic effect of carbon dioxide
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T59.8
Toxic effect of other specified gases, fumes and vapors
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T59.81
Toxic effect of smoke
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T59.811
Toxic effect of smoke, accidental (unintentional)
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T59.812
Toxic effect of smoke, intentional self-harm
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T59.813
Toxic effect of smoke, assault
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T59.814
Toxic effect of smoke, undetermined
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T59.89
Toxic effect of other specified gases, fumes and vapors
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T59.891
Toxic effect of other specified gases, fumes and vapors, accidental (unintentional)
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T59.892
Toxic effect of other specified gases, fumes and vapors, intentional self-harm
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T59.893
Toxic effect of other specified gases, fumes and vapors, assault
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T59.894
Toxic effect of other specified gases, fumes and vapors, undetermined
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T59.9
Toxic effect of unspecified gases, fumes and vapors
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T59.91
Toxic effect of unspecified gases, fumes and vapors, accidental (unintentional)
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T59.92
Toxic effect of unspecified gases, fumes and vapors, intentional self-harm
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T59.93
Toxic effect of unspecified gases, fumes and vapors, assault
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T59.94
Toxic effect of unspecified gases, fumes and vapors, undetermined
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T60
Toxic effect of pesticides
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T60.0
Toxic effect of organophosphate and carbamate insecticides
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T60.1
Toxic effect of halogenated insecticides
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T60.2
Toxic effect of other insecticides
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T60.3
Toxic effect of herbicides and fungicides
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T60.4
Toxic effect of rodenticides
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T60.8
Toxic effect of other pesticides
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T60.9
Toxic effect of unspecified pesticide
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T60.91
Toxic effect of unspecified pesticide, accidental (unintentional)
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T60.92
Toxic effect of unspecified pesticide, intentional self-harm
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T60.93
Toxic effect of unspecified pesticide, assault
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T60.94
Toxic effect of unspecified pesticide, undetermined
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T61
Toxic effect of noxious substances eaten as seafood
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T61.0
Ciguatera fish poisoning
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T61.01
Ciguatera fish poisoning, accidental (unintentional)
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T61.02
Ciguatera fish poisoning, intentional self-harm
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T61.03
Ciguatera fish poisoning, assault
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T61.04
Ciguatera fish poisoning, undetermined
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T61.1
Scombroid fish poisoning
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T61.11
Scombroid fish poisoning, accidental (unintentional)
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T61.12
Scombroid fish poisoning, intentional self-harm
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T61.13
Scombroid fish poisoning, assault
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T61.14
Scombroid fish poisoning, undetermined
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T61.7
Other fish and shellfish poisoning
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T61.77
Other fish poisoning
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T61.771
Other fish poisoning, accidental (unintentional)
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T61.772
Other fish poisoning, intentional self-harm
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T61.773
Other fish poisoning, assault
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T61.774
Other fish poisoning, undetermined
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T61.78
Other shellfish poisoning
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T61.781
Other shellfish poisoning, accidental (unintentional)
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T61.782
Other shellfish poisoning, intentional self-harm
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T61.783
Other shellfish poisoning, assault
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T61.784
Other shellfish poisoning, undetermined
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T61.8
Toxic effect of other seafood
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T61.9
Toxic effect of unspecified seafood
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T61.91
Toxic effect of unspecified seafood, accidental (unintentional)
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T61.92
Toxic effect of unspecified seafood, intentional self-harm
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T61.93
Toxic effect of unspecified seafood, assault
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T61.94
Toxic effect of unspecified seafood, undetermined
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T62
Toxic effect of other noxious substances eaten as food
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T62.0
Toxic effect of ingested mushrooms
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T62.1
Toxic effect of ingested berries
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T62.2
Toxic effect of other ingested (parts of) plant(s)
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T62.8
Toxic effect of other specified noxious substances eaten as food
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T62.9
Toxic effect of unspecified noxious substance eaten as food
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T62.91
Toxic effect of unspecified noxious substance eaten as food, accidental (unintentional)
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T62.92
Toxic effect of unspecified noxious substance eaten as food, intentional self-harm
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T62.93
Toxic effect of unspecified noxious substance eaten as food, assault
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T62.94
Toxic effect of unspecified noxious substance eaten as food, undetermined
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T63
Toxic effect of contact with venomous animals and plants
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T63.0
Toxic effect of snake venom
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T63.00
Toxic effect of unspecified snake venom
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T63.001
Toxic effect of unspecified snake venom, accidental (unintentional)
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T63.002
Toxic effect of unspecified snake venom, intentional self-harm
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T63.003
Toxic effect of unspecified snake venom, assault
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T63.004
Toxic effect of unspecified snake venom, undetermined
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T63.01
Toxic effect of rattlesnake venom
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T63.011
Toxic effect of rattlesnake venom, accidental (unintentional)
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T63.012
Toxic effect of rattlesnake venom, intentional self-harm
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T63.013
Toxic effect of rattlesnake venom, assault
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T63.014
Toxic effect of rattlesnake venom, undetermined
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T63.02
Toxic effect of coral snake venom
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T63.021
Toxic effect of coral snake venom, accidental (unintentional)
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T63.022
Toxic effect of coral snake venom, intentional self-harm
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T63.023
Toxic effect of coral snake venom, assault
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T63.024
Toxic effect of coral snake venom, undetermined
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T63.03
Toxic effect of taipan venom
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T63.031
Toxic effect of taipan venom, accidental (unintentional)
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T63.032
Toxic effect of taipan venom, intentional self-harm
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T63.033
Toxic effect of taipan venom, assault
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T63.034
Toxic effect of taipan venom, undetermined
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T63.04
Toxic effect of cobra venom
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T63.041
Toxic effect of cobra venom, accidental (unintentional)
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T63.042
Toxic effect of cobra venom, intentional self-harm
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T63.043
Toxic effect of cobra venom, assault
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T63.044
Toxic effect of cobra venom, undetermined
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Updates & Changes

FY 2026 Updates

Current Year

New Codes (2)

T40.411A
Poisoning by fentanyl, accidental (unintentional), initial encounter
T40.491A
Poisoning by other synthetic narcotics, accidental (unintentional), initial encounter

Revised Codes (1)

T40.2X1A
Poisoning by other opioids, accidental (unintentional) - updated to include synthetic opioid specifications

Deleted Codes

No codes deleted in this range for FY 2026

Historical Changes

  • •FY 2025: Routine maintenance updates with minor terminology clarifications
  • •FY 2024: Enhanced specificity requirements for certain code ranges
  • •FY 2023: Updated documentation guidelines for improved clarity

Upcoming Changes

  • •Proposed updates pending review by Coordination and Maintenance Committee
  • •Under consideration: Enhanced digital health integration codes

Implementation Guidance

  • •Review all FY 2026 updates for T51-T65 codes before implementation
  • •Always verify the most current codes in the ICD-10-CM manual
  • •Ensure clinical documentation supports the selected diagnosis codes
  • +3 more guidance items...

Range Overview

high priority

The ICD-10 category T51-T65 encompasses codes for toxic effects of substances chiefly nonmedicinal as to source. These codes are used to document cases where patients have been exposed to harmful substances, including alcohol, drugs, heavy metals, and other toxins, which are not typically considered medicinal. They cover both acute and chronic conditions, and can include intentional and unintentional exposures, as well as adverse effects in therapeutic use and complications of care.

Key Usage Points:

  • •Always code for the specific substance involved in the toxic exposure.
  • •Include additional codes for all associated manifestations.
  • •Use additional code(s) for any personal history of substance abuse.
  • •For adverse effects in therapeutic use, assign first the code for the nature of the adverse effect, followed by the code for the toxic effect.
  • •For underdosing, assign the code from categories T36-T50 first, followed by the code for the condition for which the drug was prescribed.

Coding Guidelines

When to Use:

  • ✓When a patient presents with symptoms due to exposure to a toxic substance.
  • ✓When a patient has a known history of substance abuse and presents with related complications.
  • ✓When a patient has an adverse reaction to a substance used in therapeutic doses.
  • ✓When a patient is seen for follow-up care after treatment for toxic exposure.
  • ✓When a patient is seen for complications of care related to treatment for toxic exposure.

When NOT to Use:

  • ✗When a patient has a reaction to a medication prescribed for therapeutic use (use adverse effect codes instead).
  • ✗When a patient has a reaction to a substance that is typically considered medicinal (use poisoning codes instead).
  • ✗When a patient has a condition that is due to long-term exposure to a substance (use chronic exposure codes instead).
  • ✗When a patient has a condition that is due to a substance that is not typically considered toxic (use other codes as appropriate).

Code Exclusions

Always verify exclusions with the patient's medical record and the official ICD-10 coding guidelines.

Documentation Requirements

Documentation for codes in the T51-T65 range should include the specific substance involved, the nature of the exposure (acute, chronic, intentional, unintentional, adverse effect in therapeutic use, underdosing), and all associated manifestations. It should also include any relevant history of substance abuse and any complications of care.

Clinical Information:

  • •Specific substance involved
  • •Nature of exposure
  • •Associated manifestations
  • •History of substance abuse
  • •Complications of care

Supporting Evidence:

  • •Laboratory test results
  • •Imaging studies
  • •Physician's clinical notes
  • •Emergency medical services report
Good Documentation Example:

Patient presented with acute respiratory distress and confusion after unintentional ingestion of a cleaning product. Lab tests confirmed toxic exposure. Patient has a history of dementia.

Poor Documentation Example:

Patient presented with breathing problems and confusion.

Common Documentation Errors:

  • âš Not specifying the substance involved
  • âš Not documenting the nature of the exposure
  • âš Not including codes for all associated manifestations
  • âš Not including codes for history of substance abuse when relevant
  • âš Not including codes for complications of care when relevant

Range Statistics

15
Total Codes
0
Billable
Complexity:
Medium
Primary Use:Clinical Documentation
Chapter:

Coding Complexity

Medium
Complexity Rating

Coding for toxic effects of substances chiefly nonmedicinal as to source can be complex due to the need to identify the specific substance involved, determine the nature of the exposure, identify all associated manifestations, and include codes for any relevant history of substance abuse and any complications of care. However, with careful review of the patient's medical record and the official ICD-10 coding guidelines, these codes can be applied accurately and effectively.

Key Factors:
  • â–¸Identifying the specific substance involved
  • â–¸Determining the nature of the exposure
  • â–¸Identifying all associated manifestations
  • â–¸Identifying any relevant history of substance abuse
  • â–¸Identifying any complications of care

Specialty Focus

These codes are most commonly used in emergency medicine, toxicology, and occupational medicine. They may also be used in other specialties when patients present with conditions related to toxic exposure.

Primary Specialties:
Emergency Medicine
40%
Toxicology
30%
Occupational Medicine
30%
Clinical Scenarios:
  • • A patient presents to the ER with acute respiratory distress and confusion after unintentionally ingesting a cleaning product.
  • • A patient is seen in an occupational medicine clinic for chronic respiratory symptoms due to long-term exposure to asbestos in the workplace.
  • • A patient is seen in a toxicology clinic for follow-up care after treatment for lead poisoning.
  • • A patient with a history of alcohol abuse is seen in a primary care clinic for liver damage related to chronic alcohol use.
  • • A patient is seen in the ER for complications of care after treatment for toxic exposure.

Resources & References

There are many resources available to help with coding for toxic effects of substances chiefly nonmedicinal as to source. These include the official ICD-10 coding guidelines, clinical reference materials, and educational materials from professional coding organizations.

Official Guidelines:

  • ICD-10-CM Official Guidelines for Coding and Reporting
  • World Health Organization (WHO) ICD-10 guidelines
  • Centers for Disease Control and Prevention (CDC) ICD-10 resources

Clinical References:

  • American College of Medical Toxicology resources
  • American Academy of Clinical Toxicology resources

Educational Materials:

  • American Health Information Management Association (AHIMA) ICD-10 training materials
  • American Academy of Professional Coders (AAPC) ICD-10 resources

Frequently Asked Questions

How do I code for a patient with an adverse reaction to a substance used in therapeutic doses?

First, assign the code for the nature of the adverse effect. Then, assign the code for the toxic effect of the substance.