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v1.0.0
ICD-10 Guide
ICD-10 CodesC81.0

C81.0

Billable

Nodular lymphocyte predominant Hodgkin lymphoma

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C81.0 is a billable code used to indicate a diagnosis of nodular lymphocyte predominant hodgkin lymphoma.

Key Diagnostic Point:

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma characterized by the presence of large, atypical Reed-Sternberg cells surrounded by a background of small lymphocytes. This lymphoma typically presents in younger adults and is often localized to lymph nodes, particularly in the cervical region. Patients may exhibit B-symptoms such as fever, night sweats, and weight loss, although these symptoms are less common in NLPHL compared to classical Hodgkin lymphoma. The disease is generally indolent, with a favorable prognosis, especially when diagnosed at an early stage. Staging is crucial and follows the Ann Arbor classification, which assesses the extent of lymph node involvement and any extranodal disease. Treatment protocols often include a combination of chemotherapy and radiation therapy, tailored to the stage of the disease and the patient's overall health. The unique histological features of NLPHL necessitate careful differentiation from other lymphomas, making accurate coding essential for appropriate management and reimbursement.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from classical Hodgkin lymphoma
  • Staging requirements and implications for treatment
  • Presence of B-symptoms and their documentation
  • Variability in treatment protocols based on disease stage

Audit Risk Factors

  • Inadequate documentation of staging
  • Failure to note B-symptoms
  • Misclassification with classical Hodgkin lymphoma
  • Lack of histological confirmation in records

Specialty Focus

Medical Specialties

Hematology/Oncology

Documentation Requirements

Detailed pathology reports, staging information, and treatment plans.

Common Clinical Scenarios

Diagnosis confirmation, treatment planning, and follow-up care.

Billing Considerations

Ensure accurate histological classification and staging documentation.

Radiology

Documentation Requirements

Imaging reports that detail lymph node involvement and any extranodal disease.

Common Clinical Scenarios

Imaging for staging and treatment response assessment.

Billing Considerations

Clear documentation of imaging findings related to lymphatic structures.

Coding Guidelines

Inclusion Criteria

Use C81.0 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis, staging, and any associated symptoms
  • Include specific details about the histological type and any treatment plans

Exclusion Criteria

Do NOT use C81.0 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

96413CPT Code

Chemotherapy administration, intravenous

Clinical Scenario

Used for patients receiving chemotherapy for NLPHL.

Documentation Requirements

Document the specific chemotherapy agents used and the duration of treatment.

Specialty Considerations

Oncology specialists should ensure accurate coding of chemotherapy regimens.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of NLPHL, improving the accuracy of data collection and reimbursement processes. The detailed classification helps in better tracking of treatment outcomes and epidemiological studies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of NLPHL, improving the accuracy of data collection and reimbursement processes. The detailed classification helps in better tracking of treatment outcomes and epidemiological studies.

Reimbursement & Billing Impact

reimbursement processes. The detailed classification helps in better tracking of treatment outcomes and epidemiological studies.

Resources

Clinical References

  • •
    American Cancer Society - Hodgkin Lymphoma

Coding & Billing References

  • •
    American Cancer Society - Hodgkin Lymphoma

Frequently Asked Questions

What is the prognosis for patients with NLPHL?

Patients with NLPHL generally have a favorable prognosis, especially when diagnosed at an early stage. The 5-year survival rate is high, and many patients can achieve long-term remission.