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ICD-10 Guide
DiagnosesAcute Myelogenous Leukemia

Acute Myelogenous Leukemia

ICD-10 Coding for Acute Myelogenous Leukemia(C92.00, C92.01)

PRIMARY SPECIALTYOncology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Acute Myelogenous Leukemia?
Essential facts and insights about Acute Myelogenous Leukemia

Key Clinical Considerations:

  • Presence of symptoms such as fatigue, fever, easy bruising or bleeding, and frequent infections.
  • Laboratory findings include elevated white blood cell count, presence of myeloblasts in peripheral blood or bone marrow, and cytogenetic abnormalities.
  • Physical examination may reveal splenomegaly, hepatomegaly, or lymphadenopathy.
  • Imaging studies are not typically required for diagnosis but may be used to assess organ involvement.
  • Severity criteria include the classification of acute myelogenous leukemia into subtypes based on cytogenetic and molecular features.

Clinical Information

Clinical Criteria & Documentation Requirements

  • Comprehensive medical history including presenting symptoms, duration, and previous treatments.
  • Specific terminology such as 'acute myelogenous leukemia' and relevant subtypes must be documented.
  • Examples include documenting laboratory results that confirm the diagnosis and treatment plans.
  • Medical necessity must be established through documentation of symptoms and diagnostic findings.
  • Quality measures may include documentation of treatment response and follow-up care.

Coding Guidelines

Usage Guidelines & Examples

  • Use C92.00 for acute myelogenous leukemia, not otherwise specified, and C92.01 for acute myelogenous leukemia with minimal residual disease.
  • Do not use these codes for chronic myeloid leukemia or other hematological malignancies.
  • C92.00 and C92.01 are specific to acute myelogenous leukemia; related codes include C91.00 for acute lymphoblastic leukemia.
  • Common errors include misclassifying acute myelogenous leukemia as chronic or failing to document the specific subtype.
  • In complex cases, ensure to document all relevant clinical findings and treatment responses to support code selection.

Code Exclusions

Important Exclusions

  • Chronic myeloid leukemia (C92.10) and other hematological malignancies are explicitly excluded.
  • Alternative codes for excluded conditions include C91 for acute lymphoblastic leukemia.
  • Conditions are excluded due to differing pathophysiology and treatment protocols.
  • Common mistakes include misdiagnosing acute myelogenous leukemia as chronic or other types of leukemia.
  • Related but distinct conditions include myelodysplastic syndromes and other forms of leukemia.

Related ICD-10 Codes

Primary Codes
C92.00
Acute myelogenous leukemia, not otherwise specified
C92.01
Acute myelogenous leukemia with minimal residual disease
Ancillary Codes
Z85.6
Z51.11
Differential Codes
C91.0-
D19
+.
C92.02

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Oncology

Specialty Applications

  • Patients diagnosed with acute myelogenous leukemia, particularly those with specific cytogenetic abnormalities.
  • Patient populations include adults, with a higher incidence in older adults and those with certain risk factors such as previous chemotherapy.
  • Clinical settings include inpatient oncology units and outpatient hematology clinics.
  • Specialty-specific applications are relevant in oncology and hematology practices.
  • Treatment contexts include chemotherapy regimens, stem cell transplantation, and supportive care.

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Template 1

Template: 'Patient diagnosed with acute myelogenous leukemia based on clinical findings and laboratory results.'

Template 2

Template: 'Clinical presentation consistent with acute myelogenous leukemia including fatigue and elevated white blood cell count.'

Template 3

Template: 'Diagnostic criteria met as evidenced by presence of myeloblasts in bone marrow.'

Template 4

Template: 'Treatment plan initiated for acute myelogenous leukemia with chemotherapy regimen.'

Template 5

Template: 'Follow-up care for acute myelogenous leukemia including monitoring of blood counts and treatment response.'

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What documentation is required for this diagnosis?

Documentation must include clinical findings, laboratory results, and treatment plans.

How does this differ from similar diagnoses?

Acute myelogenous leukemia is characterized by specific genetic mutations and clinical presentations that differ from other leukemias.

What are common billing considerations?

Ensure accurate coding to reflect the specific subtype and document medical necessity to optimize reimbursement.

What procedures are typically associated?

Related CPT codes include those for chemotherapy administration and bone marrow biopsy.

Are there any quality reporting implications?

Quality measures may include tracking treatment response and adherence to clinical guidelines.