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ICD-10 Guide
DiagnosesAcute Myeloid Leukemia

Acute Myeloid Leukemia

ICD-10 Coding for Acute Myeloid Leukemia(C92.00, C92.01)

PRIMARY SPECIALTYOncology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Acute Myeloid Leukemia?
Essential facts and insights about Acute Myeloid Leukemia

Key Clinical Considerations:

  • Presence of symptoms such as fatigue, fever, easy bruising or bleeding, and frequent infections.
  • Laboratory findings including elevated white blood cell count, presence of myeloblasts in peripheral blood or bone marrow, and cytogenetic abnormalities.
  • Physical examination may reveal splenomegaly, hepatomegaly, or lymphadenopathy.
  • Imaging studies are typically not required for diagnosis but may be used to assess for organ involvement.
  • Staging is not typically used for acute myeloid leukemia; however, risk stratification based on cytogenetics and molecular markers is important.

Clinical Information

Clinical Criteria & Documentation Requirements

  • Complete medical history and physical examination findings must be documented.
  • Specific terminology such as 'acute myeloid leukemia' and relevant subtypes must be used.
  • Examples include documenting the presence of myeloblasts and any cytogenetic findings.
  • Medical necessity must be established through documentation of symptoms and diagnostic tests.
  • Quality measures may include documentation of treatment response and follow-up care.

Coding Guidelines

Usage Guidelines & Examples

  • Use C92.00 for acute myeloid leukemia, not otherwise specified, and C92.01 for acute myeloid leukemia with minimal differentiation.
  • Do not use these codes for chronic myeloid leukemia or other hematological malignancies.
  • C92.00 and C92.01 are specific to acute myeloid leukemia; related codes include C92.10 for chronic myeloid leukemia.
  • Common errors include misclassifying acute myeloid leukemia as chronic or failing to document the specific subtype.
  • In complex cases, ensure to document all relevant clinical findings and laboratory results to support code selection.

Code Exclusions

Important Exclusions

  • Chronic myeloid leukemia (C92.10, C92.11) is explicitly excluded.
  • Use C92.10 for chronic myeloid leukemia instead of acute codes.
  • Conditions are excluded due to differing pathophysiology and treatment protocols.
  • Common mistakes include misdiagnosing acute myeloid leukemia as chronic myeloid leukemia.
  • Related but distinct conditions include acute lymphoblastic leukemia and myelodysplastic syndromes.

Related ICD-10 Codes

Primary Codes
C92.00
Acute myeloid leukemia, not otherwise specified
C92.01
Acute myeloid leukemia with minimal differentiation
Ancillary Codes
D46.-
Differential Codes
C92.01
C92.00

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Oncology

Specialty Applications

  • Patients diagnosed with acute myeloid leukemia.
  • Typically affects adults, but can occur in children; risk factors include previous chemotherapy or radiation exposure.
  • Clinical settings include inpatient oncology units and outpatient hematology clinics.
  • Oncology specialty-specific applications for treatment and management.
  • Used in treatment contexts such as chemotherapy regimens and stem cell transplantation.

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Template 1

Template: 'Patient diagnosed with acute myeloid leukemia based on clinical findings and laboratory results.'

Template 2

Template: 'Clinical presentation consistent with acute myeloid leukemia including fatigue and elevated white blood cell count.'

Template 3

Template: 'Diagnostic criteria for acute myeloid leukemia met as evidenced by the presence of myeloblasts in bone marrow.'

Template 4

Template: 'Treatment plan initiated for acute myeloid leukemia with chemotherapy regimen.'

Template 5

Template: 'Follow-up care for acute myeloid leukemia including monitoring of blood counts and response to treatment.'

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What documentation is required for this diagnosis?

Documentation must include clinical findings, laboratory results, and treatment plans.

How does this differ from similar diagnoses?

Acute myeloid leukemia is characterized by myeloblast proliferation, unlike acute lymphoblastic leukemia which involves lymphoblasts.

What are common billing considerations?

Ensure accurate coding to reflect the specific type of leukemia for optimal reimbursement.

What procedures are typically associated?

Common procedures include bone marrow biopsy and cytogenetic testing.

Are there any quality reporting implications?

Quality measures may include tracking treatment response and adherence to clinical guidelines.