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ICD-10 Guide
DiagnosesAdenocarcinoma Of Endometrium

Adenocarcinoma Of Endometrium

ICD-10 Coding for Adenocarcinoma of Endometrium(C54.1, 8380/3)

PRIMARY SPECIALTYPathology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Adenocarcinoma Of Endometrium?
Essential facts and insights about Adenocarcinoma of Endometrium

Key Clinical Considerations:

  • Patients may present with abnormal uterine bleeding, pelvic pain, or weight loss.
  • Histological examination of endometrial tissue showing glandular differentiation consistent with adenocarcinoma.
  • Physical examination may reveal an enlarged uterus or palpable masses.
  • Transvaginal ultrasound or MRI may show thickened endometrial lining or masses.
  • Staging is based on the FIGO system, with stages I-IV indicating the extent of disease spread.

Clinical Information

Clinical Criteria & Documentation Requirements

  • Complete medical history including menstrual history and risk factors such as obesity or family history.
  • Specific terminology such as 'endometrial adenocarcinoma' must be documented in the medical record.
  • Examples include documenting the histological type and grade of the tumor.
  • Medical necessity must be established for diagnostic tests and treatments provided.
  • Quality measures may include documentation of staging and treatment plans.

Coding Guidelines

Usage Guidelines & Examples

  • Use this diagnosis code when a patient is definitively diagnosed with endometrial adenocarcinoma.
  • Do not use this code for benign endometrial conditions or other types of cancer.
  • Compare with C54.0 (malignant neoplasm of endometrium, unspecified) for cases without specific histology.
  • Common errors include coding based on preliminary findings rather than confirmed diagnosis.
  • In complex cases, ensure all relevant clinical findings and histological reports are included.

Code Exclusions

Important Exclusions

  • Excludes benign endometrial conditions such as endometrial hyperplasia.
  • Alternative codes for excluded conditions include N85.0 (endometrial hyperplasia) for non-cancerous growths.
  • Conditions are excluded to ensure accurate representation of malignant disease.
  • Common mistakes include misclassifying benign conditions as malignant due to similar symptoms.
  • Related but distinct conditions include uterine sarcomas and other types of endometrial cancer.

Related ICD-10 Codes

Primary Codes
C54.1
Malignant neoplasm of endometrium, adenocarcinoma
C54.0
Malignant neoplasm of endometrium, unspecified
Ancillary Codes
N85.0
Differential Codes
C54.2
C54.2
if the tumor invades the myometrium.

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Pathology

Specialty Applications

  • This diagnosis applies to patients with confirmed endometrial adenocarcinoma.
  • Higher incidence in postmenopausal women, particularly those with risk factors like obesity.
  • Clinical settings include outpatient gynecologic oncology clinics and inpatient surgical units.
  • Specialty-specific applications are relevant in oncology, gynecology, and pathology.
  • Treatment contexts include surgical intervention, chemotherapy, and radiation therapy.

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Template 1

Template: 'Patient diagnosed with adenocarcinoma of the endometrium based on biopsy results.'

Template 2

Template: 'Clinical presentation consistent with endometrial adenocarcinoma including abnormal bleeding and pelvic pain.'

Template 3

Template: 'Diagnostic criteria met as evidenced by histological findings of adenocarcinoma.'

Template 4

Template: 'Treatment plan initiated for adenocarcinoma with surgical intervention and chemotherapy.'

Template 5

Template: 'Follow-up care for adenocarcinoma including monitoring for recurrence and side effects of treatment.'

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What documentation is required for this diagnosis?

Histopathology reports, imaging results, and clinical notes detailing symptoms and findings.

How does this differ from similar diagnoses?

Adenocarcinoma is characterized by glandular differentiation, unlike other types such as sarcoma.

What are common billing considerations?

Ensure that all services provided are medically necessary and well-documented to avoid claim denials.

What procedures are typically associated?

Commonly associated procedures include hysterectomy, staging laparotomy, and chemotherapy administration.

Are there any quality reporting implications?

Quality measures may include adherence to treatment guidelines and documentation of staging.