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ICD-10 Guide
DiagnosesProlactin

Prolactin

ICD-10 Coding for Prolactin Disorders(E22.1)

PRIMARY SPECIALTYEndocrinology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Prolactin?
Essential facts and insights about Prolactin Disorders

Key Clinical Considerations:

  • Galactorrhea (milk production not associated with childbirth or nursing)
  • Menstrual irregularities (amenorrhea or oligomenorrhea)
  • Infertility or decreased libido in both genders
  • Key diagnostic tests: Serum prolactin levels, MRI of the pituitary gland
  • Physical exam findings: Breast tenderness or enlargement, signs of hypogonadism

Clinical Information

Clinical Criteria & Documentation Requirements

  • Required documentation elements: Patient history, symptoms, lab results, imaging studies
  • Specific coding terminology: Hyperprolactinemia, prolactinoma, secondary causes of elevated prolactin
  • Documentation examples: 'Patient presents with galactorrhea and elevated serum prolactin levels. MRI shows pituitary adenoma.'

Coding Guidelines

Usage Guidelines & Examples

  • Usage guidelines: Use E22.1 for hyperprolactinemia; D35.2 for pituitary adenomas.
  • Common errors: Misclassifying secondary causes of elevated prolactin.

Code Exclusions

Important Exclusions

  • Excluded conditions: Conditions causing secondary hyperprolactinemia (e.g., hypothyroidism, renal failure).
  • Alternative codes: Consider E03.9 for hypothyroidism if applicable.

Related ICD-10 Codes

Primary Codes
E22.1
Hyperprolactinemia
D35.2
Benign neoplasm of pituitary gland
Ancillary Codes
C75.3
E22.1
when MRI confirms adenoma.
Differential Codes
O92.5

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Endocrinology

Specialty Applications

  • Patient populations: Individuals with reproductive issues, pituitary disorders.
  • Clinical settings: Endocrinology clinics, fertility centers, general practice.

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

Documentation requirements?

Include patient history, symptoms, lab results, and imaging findings.

Billing considerations?

Ensure accurate coding of underlying conditions and associated symptoms.