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v1.0.0
ICD-10 Guide
ICD-10 CodesA41.50

A41.50

Gram-negative sepsis, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A41.50 is a billable code used to indicate a diagnosis of gram-negative sepsis, unspecified.

Key Diagnostic Point:

Gram-negative sepsis is a severe systemic infection caused by gram-negative bacteria, which can lead to multi-organ failure and death if not promptly treated. The condition is characterized by the presence of bacteria in the bloodstream, triggering a systemic inflammatory response. Clinically, patients may present with fever, chills, tachycardia, hypotension, and altered mental status. The diagnosis is often made based on clinical signs, laboratory findings, and cultures that identify the causative organism. Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, are common culprits. Treatment typically involves aggressive fluid resuscitation, vasopressors, and broad-spectrum antibiotics, with a focus on antimicrobial stewardship to minimize resistance. Patients with gram-negative sepsis often require intensive care unit (ICU) management due to the potential for rapid deterioration and the need for close monitoring and supportive care. Early recognition and intervention are critical to improving outcomes in these patients.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of potential underlying infections leading to sepsis
  • Need for precise documentation of causative organisms
  • Differentiation from other types of sepsis (e.g., gram-positive, fungal)
  • Variability in clinical presentation and severity

Audit Risk Factors

  • Inadequate documentation of the source of infection
  • Failure to specify the type of gram-negative bacteria
  • Lack of evidence for systemic inflammatory response syndrome (SIRS)
  • Inconsistent clinical indicators for sepsis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed documentation of the organism identified, clinical presentation, and treatment plan.

Common Clinical Scenarios

Patients presenting with fever and hypotension, requiring hospitalization and IV antibiotics.

Billing Considerations

Ensure that cultures are documented and results are linked to the diagnosis.

Critical Care Medicine

Documentation Requirements

Comprehensive notes on patient monitoring, interventions, and response to treatment.

Common Clinical Scenarios

Patients in the ICU with severe sepsis requiring mechanical ventilation and vasopressors.

Billing Considerations

Document all supportive measures and their impact on patient outcomes.

Coding Guidelines

Inclusion Criteria

Use A41.50 When
  • According to ICD
  • CM guidelines, A41
  • 50 should be used when the specific gram
  • negative organism is not identified
  • Coders should ensure that the documentation supports the diagnosis of sepsis and that it meets the criteria for systemic inflammatory response syndrome (SIRS)

Exclusion Criteria

Do NOT use A41.50 When
No specific exclusions found.

Related CPT Codes

99223CPT Code

Initial hospital care, high complexity

Clinical Scenario

Used for patients admitted with severe sepsis requiring extensive evaluation.

Documentation Requirements

Detailed history, examination, and medical decision-making.

Specialty Considerations

Critical care documentation must support the level of service billed.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of gram-negative organisms. This specificity aids in better tracking of infection trends and improves the quality of care through targeted antimicrobial stewardship.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of gram-negative organisms. This specificity aids in better tracking of infection trends and improves the quality of care through targeted antimicrobial stewardship.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of gram-negative organisms. This specificity aids in better tracking of infection trends and improves the quality of care through targeted antimicrobial stewardship.

Resources

Clinical References

  • •
    CDC Sepsis Guidelines

Coding & Billing References

  • •
    CDC Sepsis Guidelines

Frequently Asked Questions

What is the difference between A41.50 and A41.9?

A41.50 specifies gram-negative sepsis, while A41.9 is used for unspecified sepsis. A41.50 requires documentation of the gram-negative organism involved.