ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesA41.51

A41.51

Sepsis due to Escherichia coli [E. coli]

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A41.51 is a billable code used to indicate a diagnosis of sepsis due to escherichia coli [e. coli].

Key Diagnostic Point:

Sepsis due to Escherichia coli (E. coli) is a severe systemic infection characterized by the presence of E. coli bacteria in the bloodstream, leading to a dysregulated host response. This condition can arise from various sources, including urinary tract infections, abdominal infections, or other localized infections where E. coli is the causative agent. Clinically, sepsis manifests with symptoms such as fever, chills, rapid heart rate, and confusion, and can progress to septic shock, characterized by hypotension and multi-organ dysfunction. The management of sepsis due to E. coli typically involves prompt initiation of broad-spectrum intravenous antibiotics, fluid resuscitation, and supportive care in an intensive care unit (ICU) setting. Antimicrobial stewardship is crucial to ensure appropriate antibiotic selection and to minimize the risk of resistance development. Early recognition and treatment are vital for improving patient outcomes, as delays can lead to increased morbidity and mortality. Continuous monitoring and reassessment of the patient's clinical status are essential components of care.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Differentiating between sepsis and severe sepsis
  • Identifying the source of infection accurately
  • Understanding the nuances of E. coli as a pathogen
  • Navigating the documentation requirements for sepsis

Audit Risk Factors

  • Inadequate documentation of the source of infection
  • Failure to document the severity of sepsis
  • Misclassification of sepsis as a non-severe infection
  • Lack of clear clinical indicators for the diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on the patient's infection history, laboratory results, and response to treatment.

Common Clinical Scenarios

Patients presenting with fever and signs of infection, particularly after recent surgeries or with underlying conditions.

Billing Considerations

Documentation must clearly indicate the causative organism and any relevant comorbidities.

Critical Care

Documentation Requirements

Comprehensive ICU notes including vital signs, fluid management, and antibiotic therapy.

Common Clinical Scenarios

Patients requiring intensive monitoring and treatment for septic shock.

Billing Considerations

Accurate recording of interventions and patient responses is critical for coding.

Coding Guidelines

Inclusion Criteria

Use A41.51 When
  • According to ICD
  • 10 guidelines, A41
  • 51 should be used when sepsis is confirmed to be due to E
  • Coders must ensure that the diagnosis is supported by clinical documentation and laboratory findings

Exclusion Criteria

Do NOT use A41.51 When
  • Exclusion criteria include cases where the infection is not confirmed or where another organism is identified as the primary cause

Related CPT Codes

99223CPT Code

Initial hospital care, high complexity

Clinical Scenario

Used for the initial hospital visit of a patient diagnosed with sepsis.

Documentation Requirements

Comprehensive history, examination, and medical decision-making details.

Specialty Considerations

Critical care documentation must reflect the complexity of the patient's condition.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of causative organisms like E. coli. This specificity enhances data accuracy and improves patient care by facilitating targeted treatment strategies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of causative organisms like E. coli. This specificity enhances data accuracy and improves patient care by facilitating targeted treatment strategies.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of sepsis, including the identification of causative organisms like E. coli. This specificity enhances data accuracy and improves patient care by facilitating targeted treatment strategies.

Resources

Clinical References

  • •
    CDC Sepsis Guidelines

Coding & Billing References

  • •
    CDC Sepsis Guidelines

Frequently Asked Questions

What is the importance of specifying E. coli in sepsis coding?

Specifying E. coli in sepsis coding is crucial for accurate treatment planning, epidemiological tracking, and ensuring appropriate reimbursement for the complexity of care provided.