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ICD-10 Guide
ICD-10 CodesA48.3

A48.3

Toxic shock syndrome

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A48.3 is a billable code used to indicate a diagnosis of toxic shock syndrome.

Key Diagnostic Point:

Toxic shock syndrome (TSS) is a severe and potentially life-threatening condition characterized by sudden onset of high fever, rash, hypotension, and multi-organ dysfunction. It is often associated with the presence of certain strains of Staphylococcus aureus or Streptococcus pyogenes, which produce toxins that can lead to systemic inflammatory response syndrome (SIRS). TSS can occur in both immunocompetent and immunocompromised individuals, but those with weakened immune systems are at a higher risk for opportunistic infections. Diagnostic challenges arise due to the nonspecific nature of symptoms, which can mimic other conditions such as sepsis or severe allergic reactions. Clinicians must rely on a combination of clinical presentation, laboratory findings, and patient history to confirm a diagnosis of TSS. Early recognition and treatment are critical, as the condition can progress rapidly, leading to severe complications such as renal failure, shock, and death if not addressed promptly.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of presenting symptoms that can overlap with other conditions
  • Need for thorough patient history to identify risk factors
  • Potential for misdiagnosis due to similarity with sepsis
  • Documentation of immunocompromised status may be required

Audit Risk Factors

  • Inadequate documentation of symptoms leading to misclassification
  • Failure to document immunocompromised status
  • Lack of clear linkage between clinical findings and TSS diagnosis
  • Inconsistent use of diagnostic tests to confirm TSS

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on patient history, presenting symptoms, and laboratory findings.

Common Clinical Scenarios

Patients presenting with fever, rash, and hypotension, particularly those with recent surgical procedures or infections.

Billing Considerations

Documentation must clearly establish the link between symptoms and the diagnosis of TSS, especially in immunocompromised patients.

Emergency Medicine

Documentation Requirements

Immediate documentation of vital signs, clinical presentation, and initial treatment provided.

Common Clinical Scenarios

Acute presentations of fever and shock in patients with a history of recent infections or surgeries.

Billing Considerations

Rapid assessment and documentation are crucial for accurate coding and treatment planning.

Coding Guidelines

Inclusion Criteria

Use A48.3 When
  • According to ICD
  • 10 guidelines, A48
  • 3 should be used when the clinical criteria for toxic shock syndrome are met, including the presence of fever, rash, hypotension, and evidence of multi
  • organ dysfunction
  • It is essential to document the causative organism when known

Exclusion Criteria

Do NOT use A48.3 When
No specific exclusions found.

Related CPT Codes

99285CPT Code

Emergency department visit, high severity

Clinical Scenario

Used when a patient presents with TSS symptoms requiring immediate intervention.

Documentation Requirements

Detailed notes on presenting symptoms, vital signs, and initial treatment.

Specialty Considerations

Emergency medicine specialists must document the urgency and severity of the condition.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of toxic shock syndrome, improving the ability to track and manage this serious condition. The detailed coding helps in understanding epidemiology and resource allocation for treatment.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of toxic shock syndrome, improving the ability to track and manage this serious condition. The detailed coding helps in understanding epidemiology and resource allocation for treatment.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of toxic shock syndrome, improving the ability to track and manage this serious condition. The detailed coding helps in understanding epidemiology and resource allocation for treatment.

Resources

Clinical References

  • •
    CDC Toxic Shock Syndrome Information

Coding & Billing References

  • •
    CDC Toxic Shock Syndrome Information

Frequently Asked Questions

What are the key symptoms of toxic shock syndrome?

Key symptoms include sudden high fever, rash, hypotension, and signs of multi-organ dysfunction. Patients may also experience confusion, vomiting, and diarrhea.