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ICD-10 Guide
ICD-10 CodesA48.51

A48.51

Infant botulism

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A48.51 is a billable code used to indicate a diagnosis of infant botulism.

Key Diagnostic Point:

Infant botulism is a rare but serious condition caused by the ingestion of Clostridium botulinum spores, which can germinate and produce toxin in the intestines of infants, typically those under one year of age. The condition is characterized by a progressive weakness and paralysis that can lead to respiratory failure if not treated promptly. Symptoms often include constipation, poor feeding, lethargy, hypotonia, and a characteristic 'floppy' appearance. Diagnosis is primarily clinical, supported by laboratory tests that may detect the toxin in the infant's stool or serum. The condition is particularly concerning in immunocompromised infants, as their ability to combat infections is diminished, making them more susceptible to opportunistic infections. The diagnostic challenges arise from the nonspecific nature of the initial symptoms, which can mimic other conditions, leading to potential delays in appropriate treatment. Early recognition and supportive care are critical for recovery, and while most infants recover fully, the condition can be life-threatening if not addressed swiftly.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating from other forms of botulism.
  • Identifying symptoms that overlap with other pediatric conditions.
  • Need for laboratory confirmation of toxin presence.
  • Variability in clinical presentation among infants.

Audit Risk Factors

  • Inadequate documentation of clinical symptoms.
  • Failure to document laboratory test results.
  • Misclassification of the condition as another type of botulism.
  • Lack of clear linkage between diagnosis and treatment provided.

Specialty Focus

Medical Specialties

Pediatrics

Documentation Requirements

Detailed clinical notes on symptoms, onset, and progression of the condition.

Common Clinical Scenarios

Infants presenting with hypotonia and feeding difficulties.

Billing Considerations

Documentation must clearly indicate the age of the patient and any laboratory findings.

Infectious Disease

Documentation Requirements

Comprehensive records of diagnostic tests and treatment plans.

Common Clinical Scenarios

Infants with suspected infections requiring differential diagnosis.

Billing Considerations

Consideration of the infant's immunocompromised status and potential for opportunistic infections.

Coding Guidelines

Inclusion Criteria

Use A48.51 When
  • According to ICD
  • 10 coding guidelines, A48
  • 51 should be used when the diagnosis of infant botulism is confirmed through clinical evaluation and laboratory testing

Exclusion Criteria

Do NOT use A48.51 When
  • Exclusion criteria include other forms of botulism and conditions that mimic the symptoms of infant botulism

Related CPT Codes

87449CPT Code

Botulinum toxin assay

Clinical Scenario

Used when testing for botulinum toxin in suspected cases of infant botulism.

Documentation Requirements

Document the clinical rationale for testing and results.

Specialty Considerations

Pediatric specialists should ensure that testing aligns with clinical findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infant botulism, improving the accuracy of data collection and analysis. This specificity aids in better tracking of the condition and its epidemiology.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infant botulism, improving the accuracy of data collection and analysis. This specificity aids in better tracking of the condition and its epidemiology.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of infant botulism, improving the accuracy of data collection and analysis. This specificity aids in better tracking of the condition and its epidemiology.

Resources

Clinical References

  • •
    CDC - Botulism

Coding & Billing References

  • •
    CDC - Botulism

Frequently Asked Questions

What are the common symptoms of infant botulism?

Common symptoms include constipation, poor feeding, lethargy, hypotonia, and respiratory distress.

How is infant botulism diagnosed?

Diagnosis is primarily clinical, supported by laboratory tests that detect botulinum toxin in stool or serum.

What is the treatment for infant botulism?

Treatment typically involves supportive care, including monitoring respiratory function and providing nutritional support.

Can infant botulism be prevented?

Avoiding honey and ensuring proper food handling can help prevent infant botulism.