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ICD-10 Guide
ICD-10 CodesA49.2

A49.2

Bacterial infection of unspecified site, unspecified.

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A49.2 is a billable code used to indicate a diagnosis of bacterial infection of unspecified site, unspecified..

Key Diagnostic Point:

A49.2 refers to a bacterial infection that is not specified in terms of its site or type. This code is often used in cases where the exact location of the infection cannot be determined, which can be particularly challenging in immunocompromised patients. These individuals may present with atypical symptoms or vague clinical findings, making it difficult to pinpoint the source of the infection. Opportunistic infections are common in this population, as their immune systems are weakened, allowing bacteria that typically do not cause disease in healthy individuals to become pathogenic. The diagnostic process may involve a range of laboratory tests, imaging studies, and clinical evaluations to identify the underlying infection. However, due to the nonspecific nature of the symptoms and the potential for multiple infections, clinicians may resort to broad-spectrum antibiotics while awaiting culture results. This code serves as a catch-all for cases where the infection is bacterial but lacks specificity, necessitating careful documentation to support its use.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Lack of specificity regarding the infection site
  • Potential for multiple concurrent infections in immunocompromised patients
  • Variability in clinical presentation and symptoms
  • Need for comprehensive documentation to justify the use of this code

Audit Risk Factors

  • Inadequate documentation supporting the unspecified nature of the infection
  • Failure to document the patient's immunocompromised status
  • Use of broad-spectrum antibiotics without clear justification
  • Inconsistent clinical findings that do not align with the diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on symptoms, diagnostic tests performed, and treatment plans.

Common Clinical Scenarios

Patients presenting with fever, malaise, and no clear source of infection.

Billing Considerations

Documentation must clearly indicate the rationale for using A49.2, especially in immunocompromised patients.

Oncology

Documentation Requirements

Comprehensive records of the patient's cancer treatment history and current immunocompromised status.

Common Clinical Scenarios

Cancer patients experiencing febrile neutropenia without a clear infectious source.

Billing Considerations

Must document the relationship between the patient's cancer treatment and the risk of opportunistic infections.

Coding Guidelines

Inclusion Criteria

Use A49.2 When
  • According to ICD
  • 10 guidelines, A49
  • 2 should be used when a bacterial infection is confirmed but the site is not specified
  • Coders must ensure that the documentation supports the diagnosis and that other more specific codes are not applicable

Exclusion Criteria

Do NOT use A49.2 When
No specific exclusions found.

Related CPT Codes

87070CPT Code

Culture, bacterial, any source

Clinical Scenario

Used when cultures are taken to identify the bacterial infection.

Documentation Requirements

Document the source of the culture and the clinical rationale for testing.

Specialty Considerations

Infectious disease specialists may require more detailed documentation regarding the patient's history.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more detailed coding, but A49.2 remains a broad code that can lead to increased scrutiny. Coders must ensure that documentation is thorough to support its use.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more detailed coding, but A49.2 remains a broad code that can lead to increased scrutiny. Coders must ensure that documentation is thorough to support its use.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more detailed coding, but A49.2 remains a broad code that can lead to increased scrutiny. Coders must ensure that documentation is thorough to support its use.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should I use A49.2?

A49.2 should be used when a bacterial infection is confirmed but the specific site is not identified. Ensure that documentation supports the diagnosis and that other more specific codes are not applicable.