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ICD-10 Guide
ICD-10 CodesA51.0

A51.0

Primary genital syphilis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A51.0 is a billable code used to indicate a diagnosis of primary genital syphilis.

Key Diagnostic Point:

Primary genital syphilis is the initial stage of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. This stage is characterized by the appearance of a single sore, known as a chancre, at the site of infection, which is typically located on the genitalia, anus, or mouth. The chancre is usually painless and can go unnoticed, leading to delayed diagnosis and treatment. The sore typically heals on its own within three to six weeks, but without treatment, the infection can progress to secondary syphilis and beyond. Diagnosis is primarily clinical, supported by serological tests such as the rapid plasma reagin (RPR) or the Venereal Disease Research Laboratory (VDRL) tests, followed by confirmatory treponemal tests. Treatment involves the administration of benzathine penicillin G, which is effective in eradicating the infection. Contact tracing is crucial to prevent further transmission, as syphilis is highly contagious during this stage. Education on safe sexual practices is also essential to reduce the risk of reinfection and transmission.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other STIs with similar presentations.
  • Need for accurate documentation of clinical findings.
  • Potential for co-infection with other sexually transmitted infections.
  • Variability in presentation among different populations.

Audit Risk Factors

  • Inadequate documentation of the chancre's characteristics.
  • Failure to document patient history of sexual partners.
  • Lack of follow-up documentation for treatment efficacy.
  • Misclassification of the stage of syphilis.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on the presentation of the chancre and serological test results.

Common Clinical Scenarios

Patients presenting with genital ulcers or sores, often with a history of unprotected sexual contact.

Billing Considerations

Consideration of co-infections and the need for comprehensive STI screening.

Family Medicine

Documentation Requirements

Thorough sexual history and documentation of patient education on STI prevention.

Common Clinical Scenarios

Routine screening in high-risk populations and management of symptomatic patients.

Billing Considerations

Importance of contact tracing and follow-up care.

Coding Guidelines

Inclusion Criteria

Use A51.0 When
  • According to the ICD
  • 10 coding guidelines, A51
  • 0 should be used when the diagnosis of primary genital syphilis is confirmed
  • It is important to document the clinical findings and any serological test results

Exclusion Criteria

Do NOT use A51.0 When
  • Exclusion criteria include other causes of genital ulcers that are not related to syphilis

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used to confirm diagnosis of primary genital syphilis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists may require additional serological tests.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and facilitating better tracking of STI trends and treatment outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and facilitating better tracking of STI trends and treatment outcomes.

Reimbursement & Billing Impact

reimbursement and compliance.

Resources

Clinical References

  • •
    CDC Syphilis Fact Sheet

Coding & Billing References

  • •
    CDC Syphilis Fact Sheet

Frequently Asked Questions

What are the symptoms of primary genital syphilis?

The primary symptom is a painless sore (chancre) at the site of infection, which may go unnoticed. Other systemic symptoms may not appear until later stages.