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ICD-10 Guide
ICD-10 CodesA51.45

A51.45

Secondary syphilitic hepatitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A51.45 is a billable code used to indicate a diagnosis of secondary syphilitic hepatitis.

Key Diagnostic Point:

Secondary syphilitic hepatitis is a manifestation of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. This condition occurs when the syphilis infection spreads to the liver, leading to inflammation and potential liver dysfunction. Patients may present with symptoms such as jaundice, abdominal pain, and elevated liver enzymes. Diagnosis typically involves serological testing for syphilis, including non-treponemal tests (e.g., RPR, VDRL) and treponemal tests (e.g., FTA-ABS). Treatment primarily involves the administration of penicillin, which is effective in eradicating the infection and alleviating liver inflammation. It is crucial for healthcare providers to conduct thorough sexual history assessments and implement contact tracing to identify and treat sexual partners, thereby preventing further transmission of syphilis. Regular follow-up and monitoring of liver function tests are recommended to assess recovery and ensure resolution of hepatitis symptoms.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of sexually transmitted infections and their systemic effects.
  • Involves knowledge of serological testing and interpretation.
  • Documentation must clearly link syphilis diagnosis to liver involvement.
  • Potential for misclassification with other forms of hepatitis.

Audit Risk Factors

  • Inadequate documentation linking syphilis to liver symptoms.
  • Failure to report co-existing conditions.
  • Misinterpretation of serological test results.
  • Inconsistent coding of secondary conditions.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, serological test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with atypical symptoms of syphilis, including liver dysfunction.

Billing Considerations

Need for comprehensive sexual health assessments and partner notification.

Hepatology

Documentation Requirements

Liver function tests, imaging studies, and treatment response evaluations.

Common Clinical Scenarios

Patients with unexplained liver enzyme elevation and a history of syphilis.

Billing Considerations

Differentiating between primary liver diseases and secondary infections.

Coding Guidelines

Inclusion Criteria

Use A51.45 When
  • Follow ICD
  • CM guidelines for coding infectious diseases
  • Ensure that the diagnosis is supported by clinical documentation, including serological test results and any relevant imaging studies
  • existing conditions are documented

Exclusion Criteria

Do NOT use A51.45 When
  • Exclude other causes of hepatitis unless co

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used for diagnosing syphilis in patients with liver symptoms.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like secondary syphilitic hepatitis, improving data accuracy and facilitating better tracking of sexually transmitted infections.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like secondary syphilitic hepatitis, improving data accuracy and facilitating better tracking of sexually transmitted infections.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of secondary syphilitic hepatitis?

Common symptoms include jaundice, abdominal pain, fatigue, and elevated liver enzymes. Patients may also experience systemic symptoms related to syphilis.