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v1.0.0
ICD-10 Guide
ICD-10 CodesA51.49

A51.49

Other secondary syphilitic conditions

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A51.49 is a billable code used to indicate a diagnosis of other secondary syphilitic conditions.

Key Diagnostic Point:

Secondary syphilis is characterized by systemic manifestations of Treponema pallidum infection, which can include a variety of clinical presentations beyond the classic rash. Patients may exhibit mucous membrane lesions, such as mucous membrane pemphigoid, condylomata lata, and generalized lymphadenopathy. Other secondary conditions may involve neurological symptoms, ocular manifestations, or systemic complications that do not fit neatly into the more commonly recognized categories of secondary syphilis. Accurate diagnosis often requires serological testing and clinical correlation, as these conditions can mimic other diseases. The presence of secondary syphilitic conditions indicates a more advanced stage of syphilis, necessitating prompt treatment to prevent progression to tertiary syphilis, which can have severe long-term consequences. Treatment typically involves benzathine penicillin G, with follow-up serological testing to ensure treatment efficacy.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of clinical presentations that may not be well-documented.
  • Need for serological confirmation and correlation with clinical findings.
  • Potential overlap with other sexually transmitted infections (STIs).
  • Variability in patient presentation and symptomatology.

Audit Risk Factors

  • Inadequate documentation of clinical findings.
  • Failure to link symptoms to the diagnosis.
  • Misidentification of secondary conditions.
  • Inconsistent serological test results.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on symptoms, serological test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with atypical rashes, systemic symptoms, or complications from syphilis.

Billing Considerations

Ensure comprehensive documentation of all secondary conditions and their clinical relevance.

Dermatology

Documentation Requirements

Photographic evidence of skin lesions, detailed descriptions of lesions, and treatment responses.

Common Clinical Scenarios

Patients with skin manifestations of secondary syphilis presenting for dermatological evaluation.

Billing Considerations

Differentiating syphilitic lesions from other dermatological conditions is crucial.

Coding Guidelines

Inclusion Criteria

Use A51.49 When
  • According to ICD
  • 10 coding guidelines, A51
  • 49 should be used when a patient presents with secondary syphilitic conditions that do not fall under more specific codes
  • Coders should ensure that documentation supports the diagnosis and that all relevant clinical details are included

Exclusion Criteria

Do NOT use A51.49 When
No specific exclusions found.

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used to confirm diagnosis of secondary syphilis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A51.49 provides a means to capture the complexity of secondary syphilitic conditions that may not have been adequately represented in ICD-9.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A51.49 provides a means to capture the complexity of secondary syphilitic conditions that may not have been adequately represented in ICD-9.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A51.49 provides a means to capture the complexity of secondary syphilitic conditions that may not have been adequately represented in ICD-9.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of secondary syphilis?

Common symptoms include skin rashes, mucous membrane lesions, and generalized lymphadenopathy. Patients may also experience systemic symptoms such as fever and malaise.

How is secondary syphilis diagnosed?

Diagnosis is typically made through serological testing, including both non-treponemal and treponemal tests, along with clinical evaluation of symptoms.