ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesA52.10

A52.10

Symptomatic neurosyphilis, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.10 is a billable code used to indicate a diagnosis of symptomatic neurosyphilis, unspecified.

Key Diagnostic Point:

Symptomatic neurosyphilis is a manifestation of syphilis that affects the central nervous system, occurring in individuals who have not received adequate treatment for the infection. It can present with a variety of neurological symptoms, including headaches, altered mental status, seizures, and other cognitive impairments. The condition can arise at any stage of syphilis but is most commonly seen in the late stages. Diagnosis typically involves a combination of clinical evaluation, serological testing for syphilis, and cerebrospinal fluid analysis to identify Treponema pallidum, the causative agent. Treatment usually involves high-dose intravenous penicillin G, which is effective in eradicating the infection and alleviating symptoms. However, early diagnosis and treatment are crucial to prevent irreversible neurological damage. Given the complexity of the disease and its implications for public health, including the need for contact tracing and management of sexual partners, it is essential for healthcare providers to be vigilant in recognizing and addressing symptomatic neurosyphilis.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of neurological symptoms that can complicate diagnosis.
  • Need for comprehensive documentation of clinical findings.
  • Potential overlap with other neurological conditions.
  • Importance of accurate serological and CSF testing results.

Audit Risk Factors

  • Inadequate documentation of neurological symptoms.
  • Failure to document serological test results.
  • Lack of detailed patient history regarding syphilis exposure.
  • Improper coding of related conditions or complications.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of syphilis infection, treatment history, and neurological assessment findings.

Common Clinical Scenarios

Patients presenting with neurological symptoms and a history of syphilis.

Billing Considerations

Ensure all relevant tests and treatments are documented to support the diagnosis.

Neurology

Documentation Requirements

Comprehensive neurological examination findings and any imaging or CSF analysis results.

Common Clinical Scenarios

Patients with cognitive decline or seizures with a known history of syphilis.

Billing Considerations

Document the relationship between neurological symptoms and syphilis to justify the diagnosis.

Coding Guidelines

Inclusion Criteria

Use A52.10 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation
  • Include any relevant laboratory results and patient history

Exclusion Criteria

Do NOT use A52.10 When
  • Exclude codes for asymptomatic neurosyphilis or other forms of syphilis that do not involve neurological symptoms

Related CPT Codes

96365CPT Code

Intravenous infusion, for therapy

Clinical Scenario

Used for administering penicillin G in severe cases of neurosyphilis.

Documentation Requirements

Document the dosage, duration, and patient response to treatment.

Specialty Considerations

Infectious disease specialists should ensure proper administration protocols are followed.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage this condition. It has also enhanced the granularity of data for public health reporting and research.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage this condition. It has also enhanced the granularity of data for public health reporting and research.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage this condition. It has also enhanced the granularity of data for public health reporting and research.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of symptomatic neurosyphilis?

Common symptoms include headaches, cognitive impairment, seizures, and changes in personality or behavior. Patients may also experience visual disturbances or other neurological deficits.

How is symptomatic neurosyphilis diagnosed?

Diagnosis involves a combination of clinical evaluation, serological testing for syphilis, and cerebrospinal fluid analysis to detect Treponema pallidum and assess for inflammation.