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ICD-10 Guide
ICD-10 CodesA52.15

A52.15

Late syphilitic neuropathy

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.15 is a billable code used to indicate a diagnosis of late syphilitic neuropathy.

Key Diagnostic Point:

Late syphilitic neuropathy is a neurological complication of syphilis that occurs in the tertiary stage of the disease. This condition is characterized by damage to the peripheral nervous system, which can lead to a variety of symptoms including pain, weakness, and sensory disturbances. Patients may experience neuropathic pain, loss of reflexes, and motor deficits. The onset of symptoms can vary, and they may develop years after the initial syphilis infection if left untreated. The pathophysiology involves the infiltration of the nervous system by Treponema pallidum, the bacterium responsible for syphilis, leading to inflammation and degeneration of nerve fibers. Diagnosis is typically made through clinical evaluation, serological testing for syphilis, and neurological examination. Treatment involves the administration of antibiotics, primarily penicillin, which can effectively manage the infection and prevent further neurological damage. Early detection and treatment are crucial to prevent the progression to late-stage complications such as neuropathy.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of syphilis stages and associated complications.
  • Differentiation from other neuropathies can be challenging.
  • Documentation must include specific neurological symptoms.
  • Need for accurate serological test results to support diagnosis.

Audit Risk Factors

  • Inadequate documentation of neurological symptoms.
  • Failure to include serological test results.
  • Misdiagnosis or coding of related conditions.
  • Inconsistent treatment documentation.

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed neurological examination findings, including sensory and motor assessments.

Common Clinical Scenarios

Patients presenting with unexplained neuropathic pain or weakness, particularly in those with a history of syphilis.

Billing Considerations

Neurologists should ensure that all relevant tests and patient history are documented to support the diagnosis.

Infectious Disease

Documentation Requirements

Comprehensive history of syphilis treatment and serological test results.

Common Clinical Scenarios

Patients with late-stage syphilis presenting with neurological symptoms.

Billing Considerations

Infectious disease specialists must document the timeline of syphilis treatment to establish the link to neuropathy.

Coding Guidelines

Inclusion Criteria

Use A52.15 When
  • According to ICD
  • 10 guidelines, A52
  • 15 should be used when there is clear documentation of late syphilitic neuropathy, supported by serological evidence of syphilis

Exclusion Criteria

Do NOT use A52.15 When
  • Exclusion criteria include other causes of neuropathy that are not related to syphilis

Related CPT Codes

96372CPT Code

Therapeutic, prophylactic, or diagnostic injection into the subcutaneous or intramuscular tissue

Clinical Scenario

Used when administering penicillin for treatment of late syphilitic neuropathy.

Documentation Requirements

Document the indication for the injection and patient response.

Specialty Considerations

Infectious disease specialists should ensure that the treatment plan is clearly outlined.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of late syphilitic neuropathy, improving the accuracy of data collection and treatment tracking. This specificity aids in better understanding the epidemiology of syphilis-related complications.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of late syphilitic neuropathy, improving the accuracy of data collection and treatment tracking. This specificity aids in better understanding the epidemiology of syphilis-related complications.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of late syphilitic neuropathy, improving the accuracy of data collection and treatment tracking. This specificity aids in better understanding the epidemiology of syphilis-related complications.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of late syphilitic neuropathy?

Common symptoms include neuropathic pain, weakness, sensory disturbances, and diminished reflexes. Patients may also experience difficulty walking and coordination issues.