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ICD-10 Guide
ICD-10 CodesA52.19

A52.19

Other symptomatic neurosyphilis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.19 is a billable code used to indicate a diagnosis of other symptomatic neurosyphilis.

Key Diagnostic Point:

Other symptomatic neurosyphilis refers to a range of neurological manifestations associated with syphilis infection that do not fall into the more commonly recognized categories of neurosyphilis, such as tabes dorsalis or general paresis. Patients may present with a variety of symptoms including headaches, altered mental status, seizures, and other neurological deficits. The condition arises from the invasion of Treponema pallidum, the bacterium responsible for syphilis, into the central nervous system. Diagnosis is typically confirmed through serological testing for syphilis, along with cerebrospinal fluid (CSF) analysis showing elevated white blood cell counts and positive treponemal tests. Treatment involves the administration of high-dose penicillin, which is effective in eradicating the infection and alleviating symptoms. Early detection and treatment are crucial to prevent long-term neurological damage and complications.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of neurological symptoms that can complicate diagnosis
  • Need for comprehensive documentation of clinical findings
  • Differentiation from other forms of neurosyphilis
  • Potential for co-infection with other STIs

Audit Risk Factors

  • Inadequate documentation of neurological symptoms
  • Failure to perform or document CSF analysis
  • Misdiagnosis due to symptom overlap with other conditions
  • Inconsistent treatment documentation

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of sexual exposure, serological test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with neurological symptoms and a history of syphilis.

Billing Considerations

Ensure all relevant tests and treatments are documented to support the diagnosis.

Neurology

Documentation Requirements

Comprehensive neurological examination findings and imaging results.

Common Clinical Scenarios

Patients with unexplained neurological deficits and a history of syphilis.

Billing Considerations

Documenting the neurological assessment is critical for accurate coding.

Coding Guidelines

Inclusion Criteria

Use A52.19 When
  • According to ICD
  • 10 coding guidelines, A52
  • 19 should be used when there is clear documentation of symptomatic neurosyphilis that does not fit into other specified categories
  • It is important to ensure that the diagnosis is supported by clinical findings and laboratory results

Exclusion Criteria

Do NOT use A52.19 When
No specific exclusions found.

Related CPT Codes

86592CPT Code

Syphilis test, non-treponemal

Clinical Scenario

Used for initial screening of syphilis in patients presenting with neurological symptoms.

Documentation Requirements

Document the reason for testing and the results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing is performed.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage cases effectively. A52.19 provides a distinct code for symptomatic cases that may have been previously coded under broader categories.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage cases effectively. A52.19 provides a distinct code for symptomatic cases that may have been previously coded under broader categories.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of neurosyphilis, improving the ability to track and manage cases effectively. A52.19 provides a distinct code for symptomatic cases that may have been previously coded under broader categories.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of other symptomatic neurosyphilis?

Common symptoms include headaches, seizures, altered mental status, and other neurological deficits. Each patient's presentation may vary.

How is neurosyphilis diagnosed?

Diagnosis is made through clinical evaluation, serological testing for syphilis, and cerebrospinal fluid analysis showing signs of infection.