ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesA52.2

A52.2

Late syphilis, latent

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.2 is a billable code used to indicate a diagnosis of late syphilis, latent.

Key Diagnostic Point:

Late syphilis, latent, refers to a stage of syphilis infection that occurs after the primary and secondary stages have resolved, typically occurring years after initial infection. During this phase, the individual is asymptomatic, and the infection is not transmissible through sexual contact. Latent syphilis is characterized by the absence of clinical signs and symptoms, but serological tests remain positive for Treponema pallidum, the bacterium responsible for syphilis. This stage can last for years and may progress to tertiary syphilis if left untreated, which can lead to severe complications affecting the cardiovascular system, nervous system, and other organs. Diagnosis is primarily based on serological testing, including non-treponemal tests (e.g., RPR, VDRL) and treponemal tests (e.g., FTA-ABS). Treatment typically involves the administration of benzathine penicillin G, which is effective in eradicating the infection and preventing progression to tertiary syphilis. Regular follow-up and monitoring of serological response are essential to ensure treatment efficacy.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between latent and active stages of syphilis
  • Understanding serological testing and interpretation
  • Identifying potential co-infections with other STIs
  • Documenting patient history accurately to support diagnosis

Audit Risk Factors

  • Inadequate documentation of serological test results
  • Failure to document patient history of syphilis
  • Misclassification of latent syphilis as active syphilis
  • Lack of follow-up documentation post-treatment

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Comprehensive patient history, serological test results, treatment plans, and follow-up notes.

Common Clinical Scenarios

Patients presenting with positive syphilis serology but no symptoms, or those with a history of syphilis requiring follow-up.

Billing Considerations

Ensure clarity in documentation regarding the stage of syphilis and any co-existing conditions.

Primary Care

Documentation Requirements

Detailed patient history, risk factors for STIs, and documentation of screening and treatment protocols.

Common Clinical Scenarios

Routine screening of at-risk populations and management of patients with a history of syphilis.

Billing Considerations

Documenting risk factors and ensuring appropriate referrals to specialists when necessary.

Coding Guidelines

Inclusion Criteria

Use A52.2 When
  • According to ICD
  • 10 guidelines, A52
  • 2 should be used when the patient has a documented history of syphilis with positive serological tests and no active symptoms
  • It is crucial to ensure that the diagnosis is supported by appropriate laboratory results

Exclusion Criteria

Do NOT use A52.2 When
No specific exclusions found.

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used when testing for syphilis in patients with a history of STIs.

Documentation Requirements

Document the reason for testing and the patient's history.

Specialty Considerations

Infectious disease specialists may require more detailed documentation of risk factors.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving the accuracy of epidemiological data and treatment tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving the accuracy of epidemiological data and treatment tracking.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving the accuracy of epidemiological data and treatment tracking.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What is the difference between latent and active syphilis?

Latent syphilis is asymptomatic and non-transmissible, while active syphilis presents with clinical symptoms and can be transmitted to sexual partners.