ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesA52.3

A52.3

Neurological syphilis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.3 is a billable code used to indicate a diagnosis of neurological syphilis.

Key Diagnostic Point:

Neurological syphilis is a manifestation of syphilis that affects the central nervous system (CNS). It can occur at any stage of syphilis, but is most commonly seen in late syphilis. The condition can present with a variety of neurological symptoms, including but not limited to, meningitis, encephalitis, and tabes dorsalis, which is characterized by degeneration of the spinal cord. Patients may experience headaches, visual disturbances, cognitive dysfunction, and motor deficits. Diagnosis typically involves serological testing for Treponema pallidum, the causative agent of syphilis, along with lumbar puncture to analyze cerebrospinal fluid (CSF) for signs of infection or inflammation. Treatment primarily involves the administration of high-dose penicillin, which is effective in eradicating the infection and preventing further neurological damage. Early detection and treatment are crucial to minimize long-term complications associated with neurological syphilis.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of syphilis stages and their manifestations.
  • Differentiation from other neurological conditions is necessary.
  • Documentation must include specific neurological symptoms.
  • Requires knowledge of serological testing and CSF analysis.

Audit Risk Factors

  • Inadequate documentation of neurological symptoms.
  • Failure to document serological test results.
  • Lack of clarity on treatment administered.
  • Misclassification of neurological symptoms as unrelated conditions.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of syphilis infection, treatment history, and neurological assessment.

Common Clinical Scenarios

Patients presenting with neurological symptoms and a history of syphilis.

Billing Considerations

Ensure all serological tests and CSF analysis results are documented.

Neurology

Documentation Requirements

Comprehensive neurological examination findings and diagnostic imaging results.

Common Clinical Scenarios

Patients with cognitive decline or motor deficits linked to syphilis.

Billing Considerations

Document any differential diagnoses considered during evaluation.

Coding Guidelines

Inclusion Criteria

Use A52.3 When
  • According to ICD
  • 10 coding guidelines, A52
  • 3 should be used when there is clear documentation of neurological involvement due to syphilis
  • It is important to ensure that the diagnosis is confirmed through appropriate testing and that the clinical documentation supports the coding choice

Exclusion Criteria

Do NOT use A52.3 When
No specific exclusions found.

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used to confirm syphilis diagnosis in patients with neurological symptoms.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of neurological syphilis, improving the accuracy of data collection and treatment tracking. This specificity aids in better understanding the epidemiology of the disease and enhances patient care.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of neurological syphilis, improving the accuracy of data collection and treatment tracking. This specificity aids in better understanding the epidemiology of the disease and enhances patient care.

Reimbursement & Billing Impact

reimbursement.

Resources

Clinical References

  • •
    CDC Syphilis Treatment Guidelines

Coding & Billing References

  • •
    CDC Syphilis Treatment Guidelines

Frequently Asked Questions

What are the common symptoms of neurological syphilis?

Common symptoms include headaches, cognitive dysfunction, visual disturbances, and motor deficits. Patients may also experience seizures or changes in behavior.