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ICD-10 Guide
ICD-10 CodesA52.78

A52.78

Syphilis of other musculoskeletal tissue

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A52.78 is a billable code used to indicate a diagnosis of syphilis of other musculoskeletal tissue.

Key Diagnostic Point:

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. While it primarily affects the genital area, it can also involve other systems, including the musculoskeletal system. Syphilis of other musculoskeletal tissue refers to the involvement of tissues such as bones, joints, and connective tissues that are not classified under the more common manifestations of syphilis. This condition can lead to various complications, including arthritis, osteitis, and other inflammatory responses in the musculoskeletal system. Patients may present with joint pain, swelling, and systemic symptoms such as fever and malaise. Diagnosis typically involves serological testing for syphilis, including non-treponemal tests (e.g., RPR, VDRL) and treponemal tests (e.g., FTA-ABS). Treatment usually consists of antibiotic therapy, primarily penicillin, which is effective in eradicating the infection and preventing further complications. Early detection and treatment are crucial to avoid long-term damage to the musculoskeletal system and other organs.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between various forms of syphilis and their manifestations.
  • Understanding the specific musculoskeletal involvement and its clinical implications.
  • Need for comprehensive documentation of symptoms and diagnostic tests.
  • Potential overlap with other musculoskeletal conditions.

Audit Risk Factors

  • Inadequate documentation of the specific musculoskeletal tissue affected.
  • Failure to provide supporting lab results for syphilis diagnosis.
  • Misclassification of syphilis manifestations.
  • Insufficient detail in clinical notes regarding treatment and follow-up.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, serological test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with joint pain and a history of syphilis.

Billing Considerations

Need for thorough follow-up to monitor treatment response and potential complications.

Rheumatology

Documentation Requirements

Comprehensive assessment of joint involvement and any associated systemic symptoms.

Common Clinical Scenarios

Patients with unexplained arthritis and a history of sexually transmitted infections.

Billing Considerations

Differentiating syphilis-related arthritis from other rheumatologic conditions.

Coding Guidelines

Inclusion Criteria

Use A52.78 When
  • According to ICD
  • 10 coding guidelines, A52
  • 78 should be used when syphilis specifically affects musculoskeletal tissues other than bone or joint
  • Coders must ensure that the diagnosis is supported by appropriate clinical documentation and laboratory findings

Exclusion Criteria

Do NOT use A52.78 When
  • Exclusion criteria include conditions that are not directly related to syphilis

Related CPT Codes

86592CPT Code

Syphilis test, non-treponemal

Clinical Scenario

Used when testing for syphilis in patients presenting with musculoskeletal symptoms.

Documentation Requirements

Document the reason for testing and any relevant clinical findings.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing protocols.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A52.78 provides a distinct code for musculoskeletal involvement, which was less clearly defined in ICD-9.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A52.78 provides a distinct code for musculoskeletal involvement, which was less clearly defined in ICD-9.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of syphilis-related conditions, improving the accuracy of diagnoses and treatment tracking. A52.78 provides a distinct code for musculoskeletal involvement, which was less clearly defined in ICD-9.

Resources

Clinical References

  • •
    CDC Syphilis Fact Sheet

Coding & Billing References

  • •
    CDC Syphilis Fact Sheet

Frequently Asked Questions

What are the common symptoms of syphilis affecting musculoskeletal tissue?

Common symptoms include joint pain, swelling, and systemic symptoms such as fever and malaise. Patients may also experience fatigue and general discomfort.

How is syphilis of musculoskeletal tissue diagnosed?

Diagnosis is typically made through serological testing, including both non-treponemal and treponemal tests, along with a thorough clinical evaluation.

What is the treatment for syphilis affecting musculoskeletal tissue?

The primary treatment is antibiotic therapy, usually with penicillin, which is effective in treating the infection and preventing further complications.