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v1.0.0
ICD-10 Guide
ICD-10 CodesA66.0

A66.0

Primary genital syphilis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A66.0 is a billable code used to indicate a diagnosis of primary genital syphilis.

Key Diagnostic Point:

Primary genital syphilis is the initial stage of syphilis infection, characterized by the appearance of a single sore, known as a chancre, at the site of infection. This sore is typically painless and can occur on the genitals, anus, or mouth. The chancre usually appears about three weeks after exposure to the Treponema pallidum bacterium, which is the causative agent of syphilis. If left untreated, primary syphilis can progress to secondary syphilis, which involves systemic manifestations such as rashes and flu-like symptoms. The disease is primarily transmitted through sexual contact, and its prevalence varies geographically, with higher rates often found in areas with limited access to healthcare and education about sexually transmitted infections (STIs). In endemic regions, such as parts of sub-Saharan Africa and some urban areas in the United States, the incidence of syphilis remains a public health concern, necessitating ongoing surveillance and intervention efforts.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation of syphilis stages
  • Need for accurate patient history regarding sexual activity
  • Differentiation from other STIs with similar symptoms
  • Documentation of laboratory test results confirming diagnosis

Audit Risk Factors

  • Inadequate documentation of the chancre's characteristics
  • Failure to document patient history of sexual exposure
  • Misclassification of the stage of syphilis
  • Lack of laboratory confirmation of diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, physical examination findings, and laboratory test results.

Common Clinical Scenarios

Diagnosis and management of syphilis in patients presenting with genital ulcers.

Billing Considerations

Consideration of co-infections and comprehensive STI screening.

Urology

Documentation Requirements

Clinical notes on genital examination and any relevant imaging or lab tests.

Common Clinical Scenarios

Evaluation of patients with genital lesions and differential diagnosis of STIs.

Billing Considerations

Need for clear documentation to differentiate between syphilis and other urogenital conditions.

Coding Guidelines

Inclusion Criteria

Use A66.0 When
  • According to the ICD
  • 10 coding guidelines, A66
  • 0 should be used when the diagnosis of primary genital syphilis is confirmed through clinical evaluation and laboratory testing

Exclusion Criteria

Do NOT use A66.0 When
  • Exclusion criteria include other causes of genital ulcers that are not due to syphilis

Related CPT Codes

86592CPT Code

Syphilis serology test

Clinical Scenario

Used when testing for syphilis in patients presenting with genital lesions.

Documentation Requirements

Document the reason for testing and the patient's clinical presentation.

Specialty Considerations

Infectious disease specialists should ensure comprehensive STI screening.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and enhancing public health tracking efforts.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and enhancing public health tracking efforts.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of syphilis stages, improving data accuracy and enhancing public health tracking efforts.

Resources

Clinical References

  • •
    CDC Syphilis Fact Sheet

Coding & Billing References

  • •
    CDC Syphilis Fact Sheet

Frequently Asked Questions

What are the common symptoms of primary genital syphilis?

The primary symptom is a painless sore (chancre) at the site of infection, which may be accompanied by swollen lymph nodes.