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ICD-10 Guide
ICD-10 CodesA81.9

A81.9

Atypical virus infection of central nervous system, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 A81.9 is a billable code used to indicate a diagnosis of atypical virus infection of central nervous system, unspecified.

Key Diagnostic Point:

Atypical virus infections of the central nervous system (CNS) encompass a range of viral pathogens that do not fit the classic presentations of well-known viral infections such as meningitis or encephalitis. These infections can lead to a variety of neurological complications, including seizures, altered mental status, and focal neurological deficits. The clinical presentation may be subtle and can mimic other neurological disorders, making diagnosis challenging. Common atypical viruses include those from the herpes family, arboviruses, and enteroviruses, among others. Diagnosis often relies on a combination of clinical evaluation, imaging studies, and laboratory tests, including PCR for viral DNA or RNA. Vaccination status can play a crucial role in the prevention of certain viral infections, and understanding a patient's immunization history is essential for risk assessment and management. Given the broad spectrum of atypical viral infections, the unspecified nature of this code indicates that the specific virus has not been identified, necessitating careful documentation to support the diagnosis and treatment plan.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of atypical viruses that can cause CNS infections
  • Overlap of symptoms with other neurological conditions
  • Need for comprehensive diagnostic testing
  • Documentation of vaccination status and history

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to specify vaccination history
  • Lack of supporting laboratory results
  • Misclassification of the infection type

Specialty Focus

Medical Specialties

Neurology

Documentation Requirements

Detailed neurological examination findings, imaging results, and laboratory tests.

Common Clinical Scenarios

Patients presenting with seizures, altered mental status, or focal neurological deficits without a clear viral etiology.

Billing Considerations

Ensure thorough documentation of differential diagnoses and rationale for the use of A81.9.

Infectious Disease

Documentation Requirements

Comprehensive history of exposure, vaccination status, and laboratory confirmation of atypical viral infections.

Common Clinical Scenarios

Patients with unexplained CNS symptoms following travel or exposure to endemic areas.

Billing Considerations

Highlight the importance of identifying atypical pathogens and the need for specific diagnostic tests.

Coding Guidelines

Inclusion Criteria

Use A81.9 When
  • According to ICD
  • 10 coding guidelines, A81
  • 9 should be used when the specific atypical virus causing the CNS infection is not identified
  • Coders should ensure that all relevant clinical documentation supports the diagnosis and that other potential causes have been ruled out

Exclusion Criteria

Do NOT use A81.9 When
No specific exclusions found.

Related CPT Codes

87491CPT Code

Infectious agent detection by nucleic acid (DNA or RNA); viral, amplified probe technique

Clinical Scenario

Used when testing for atypical viral infections in CNS.

Documentation Requirements

Document the reason for testing and the clinical findings leading to the suspicion of atypical infection.

Specialty Considerations

Neurology and Infectious Disease specialists should ensure that the clinical rationale for testing is clearly documented.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of atypical viral infections, improving the ability to track and manage these conditions. A81.9 provides a necessary code for cases where the specific viral agent is unknown, facilitating appropriate treatment and research.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of atypical viral infections, improving the ability to track and manage these conditions. A81.9 provides a necessary code for cases where the specific viral agent is unknown, facilitating appropriate treatment and research.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of atypical viral infections, improving the ability to track and manage these conditions. A81.9 provides a necessary code for cases where the specific viral agent is unknown, facilitating appropriate treatment and research.

Resources

Clinical References

  • •
    CDC Viral Infections and the CNS

Coding & Billing References

  • •
    CDC Viral Infections and the CNS

Frequently Asked Questions

When should I use A81.9?

A81.9 should be used when a patient presents with symptoms of a CNS infection, and the specific viral agent has not been identified despite thorough evaluation.