ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesB08.01

B08.01

Cowpox and vaccinia not from vaccine

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B08.01 is a billable code used to indicate a diagnosis of cowpox and vaccinia not from vaccine.

Key Diagnostic Point:

Cowpox is a viral infection caused by the cowpox virus, which is a member of the Orthopoxvirus genus. It primarily affects cattle but can be transmitted to humans, typically through direct contact with infected animals or contaminated materials. The clinical presentation in humans includes localized lesions that resemble those of smallpox, often starting as macules that progress to papules, vesicles, and eventually crust over. Vaccinia, on the other hand, is the virus used in the smallpox vaccine but can also cause infections outside of vaccination contexts. Infections can occur through contact with infected individuals or contaminated surfaces. Symptoms may include fever, malaise, and the characteristic rash. While cowpox is generally self-limiting and resolves without treatment, complications can arise, particularly in immunocompromised individuals, leading to more severe manifestations. Accurate diagnosis is crucial to differentiate these infections from other poxvirus-related diseases, especially in the context of vaccination history.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other poxvirus infections
  • Need for detailed patient history regarding exposure
  • Potential for complications in immunocompromised patients
  • Documentation of clinical presentation and progression

Audit Risk Factors

  • Inadequate documentation of exposure history
  • Failure to specify the source of infection
  • Misclassification with other viral infections
  • Lack of detail in clinical presentation

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, including exposure and vaccination status, clinical findings, and laboratory results.

Common Clinical Scenarios

Patients presenting with rash and fever after contact with animals or contaminated materials.

Billing Considerations

Consideration of immunocompromised status and potential complications.

Dermatology

Documentation Requirements

Photographic evidence of lesions, detailed description of rash progression, and patient history.

Common Clinical Scenarios

Patients with skin lesions resembling poxvirus infections.

Billing Considerations

Differentiation from other dermatological conditions.

Coding Guidelines

Inclusion Criteria

Use B08.01 When
  • Follow official ICD
  • 10 coding guidelines, ensuring accurate documentation of the source of infection and clinical details
  • related

Exclusion Criteria

Do NOT use B08.01 When
  • Exclude cases where the infection is vaccine

Related CPT Codes

87205CPT Code

Viral culture, isolation of virus

Clinical Scenario

Used when laboratory confirmation of cowpox or vaccinia is required.

Documentation Requirements

Document the reason for viral culture and clinical findings.

Specialty Considerations

Infectious disease specialists may require additional lab results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of viral infections, including cowpox and vaccinia, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of viral infections, including cowpox and vaccinia, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    CDC - Cowpox Virus

Coding & Billing References

  • •
    CDC - Cowpox Virus

Frequently Asked Questions

What is the main difference between cowpox and vaccinia?

Cowpox is primarily transmitted from animals to humans, while vaccinia is the virus used in the smallpox vaccine and can cause infections in humans through contact with infected individuals or materials.