ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesB27.00

B27.00

Gammaherpesviral mononucleosis without complication

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.00 is a billable code used to indicate a diagnosis of gammaherpesviral mononucleosis without complication.

Key Diagnostic Point:

Gammaherpesviral mononucleosis is primarily caused by the Epstein-Barr virus (EBV) or other gammaherpesviruses, leading to a clinical presentation similar to infectious mononucleosis. Patients typically present with symptoms such as fever, sore throat, lymphadenopathy, and fatigue. The diagnosis is often confirmed through serological testing, including heterophile antibody tests (e.g., Monospot test) and specific EBV antibody panels. In the absence of complications, the condition is generally self-limiting, with supportive care being the mainstay of treatment. Antiviral medications may be considered in severe cases or immunocompromised patients, although they are not routinely used for uncomplicated cases. The condition is characterized by the proliferation of atypical lymphocytes and can lead to splenomegaly. It is important to differentiate gammaherpesviral mononucleosis from other viral infections, such as cytomegalovirus (CMV) mononucleosis, which can present similarly but requires different management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation from other viral infections like CMV and HIV
  • Need for serological confirmation of EBV infection
  • Potential for misdiagnosis due to overlapping symptoms with other conditions
  • Documentation of absence of complications is crucial for accurate coding

Audit Risk Factors

  • Inadequate documentation of symptoms and clinical findings
  • Failure to document serological test results
  • Misclassification of the condition as a different viral infection
  • Lack of clarity on the absence of complications

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, laboratory test results, and treatment plans must be documented.

Common Clinical Scenarios

Patients presenting with fever, sore throat, and lymphadenopathy requiring differential diagnosis.

Billing Considerations

Consideration of immunocompromised status and potential complications.

Primary Care

Documentation Requirements

Comprehensive patient history and physical examination findings, including symptom duration.

Common Clinical Scenarios

Initial evaluation of patients with symptoms suggestive of mononucleosis.

Billing Considerations

Monitoring for complications and ensuring follow-up care.

Coding Guidelines

Inclusion Criteria

Use B27.00 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the clinical presentation and laboratory findings
  • Include specific details about the absence of complications to justify the use of B27

Exclusion Criteria

Do NOT use B27.00 When
No specific exclusions found.

Related CPT Codes

86790CPT Code

EBV antibody test

Clinical Scenario

Used to confirm EBV infection in patients presenting with mononucleosis symptoms.

Documentation Requirements

Document the reason for the test and the clinical findings leading to the suspicion of EBV.

Specialty Considerations

Infectious disease specialists may require more detailed serological panels.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of viral infections, improving the accuracy of data collection and reimbursement processes. B27.00 provides a clear distinction for gammaherpesviral mononucleosis without complications, which aids in clinical management and epidemiological tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of viral infections, improving the accuracy of data collection and reimbursement processes. B27.00 provides a clear distinction for gammaherpesviral mononucleosis without complications, which aids in clinical management and epidemiological tracking.

Reimbursement & Billing Impact

reimbursement processes. B27.00 provides a clear distinction for gammaherpesviral mononucleosis without complications, which aids in clinical management and epidemiological tracking.

Resources

Clinical References

  • •
    CDC - Epstein-Barr Virus

Coding & Billing References

  • •
    CDC - Epstein-Barr Virus

Frequently Asked Questions

What are the common symptoms of gammaherpesviral mononucleosis?

Common symptoms include fever, sore throat, swollen lymph nodes, and fatigue. Patients may also experience splenomegaly and atypical lymphocytes in their blood.