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ICD-10 Guide
ICD-10 CodesB27.02

B27.02

Gammaherpesviral mononucleosis with meningitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.02 is a billable code used to indicate a diagnosis of gammaherpesviral mononucleosis with meningitis.

Key Diagnostic Point:

Gammaherpesviral mononucleosis with meningitis is a viral infection characterized by the presence of the gammaherpesvirus, which includes Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). This condition typically presents with symptoms similar to infectious mononucleosis, such as fever, sore throat, lymphadenopathy, and fatigue. However, in cases where meningitis is present, patients may also exhibit neurological symptoms such as headache, neck stiffness, and altered mental status. Diagnosis is primarily made through serological testing for specific antibodies against the gammaherpesvirus, along with PCR testing to detect viral DNA in cerebrospinal fluid (CSF) when meningitis is suspected. Treatment usually involves supportive care, as antiviral medications may not be effective against gammaherpesviruses. In severe cases, particularly those involving neurological complications, antiviral therapy such as acyclovir may be considered. Monitoring for complications is crucial, as the condition can lead to significant morbidity if not managed appropriately.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between viral and bacterial meningitis
  • Need for serological and PCR testing for accurate diagnosis
  • Potential overlap with other viral infections
  • Documentation of neurological symptoms and their severity

Audit Risk Factors

  • Inadequate documentation of neurological symptoms
  • Failure to provide supporting lab results
  • Misclassification of viral versus bacterial meningitis
  • Lack of clarity in the relationship between symptoms and the diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical history, laboratory results, and treatment plans must be documented.

Common Clinical Scenarios

Patients presenting with fever, lymphadenopathy, and neurological symptoms.

Billing Considerations

Consideration of co-infections and the need for comprehensive testing.

Neurology

Documentation Requirements

Neurological examination findings, imaging results, and CSF analysis must be included.

Common Clinical Scenarios

Patients with altered mental status or severe headache alongside mononucleosis symptoms.

Billing Considerations

Documentation of neurological deficits and their progression is critical.

Coding Guidelines

Inclusion Criteria

Use B27.02 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the condition's severity and associated symptoms
  • Include specific laboratory findings and clinical assessments that support the diagnosis

Exclusion Criteria

Do NOT use B27.02 When
No specific exclusions found.

Related CPT Codes

87491CPT Code

Viral culture for herpes simplex virus

Clinical Scenario

Used when viral meningitis is suspected.

Documentation Requirements

Document the reason for testing and clinical findings.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of viral infections, improving the accuracy of diagnoses and treatment tracking for conditions like gammaherpesviral mononucleosis with meningitis.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of viral infections, improving the accuracy of diagnoses and treatment tracking for conditions like gammaherpesviral mononucleosis with meningitis.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of viral infections, improving the accuracy of diagnoses and treatment tracking for conditions like gammaherpesviral mononucleosis with meningitis.

Resources

Clinical References

  • •
    CDC Viral Meningitis Information

Coding & Billing References

  • •
    CDC Viral Meningitis Information

Frequently Asked Questions

What are the common symptoms of gammaherpesviral mononucleosis?

Common symptoms include fever, sore throat, lymphadenopathy, fatigue, and in cases with meningitis, headache and neck stiffness.

How is gammaherpesviral meningitis diagnosed?

Diagnosis is made through serological tests for antibodies and PCR testing of cerebrospinal fluid to detect viral DNA.

What treatments are available for gammaherpesviral infections?

Treatment is primarily supportive, but antiviral medications like acyclovir may be considered in severe cases.