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ICD-10 Guide
ICD-10 CodesB27.1

B27.1

Infectious mononucleosis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.1 is a billable code used to indicate a diagnosis of infectious mononucleosis.

Key Diagnostic Point:

Infectious mononucleosis, commonly known as mono, is primarily caused by the Epstein-Barr virus (EBV), a member of the herpes virus family. This viral infection is characterized by fever, sore throat, swollen lymph nodes, and fatigue. The disease is most prevalent among adolescents and young adults, although it can occur at any age. Diagnosis is typically made through clinical evaluation and serological tests, including heterophile antibody tests (such as the Monospot test) and specific EBV antibody tests. The condition is usually self-limiting, with symptoms resolving within a few weeks to months. However, complications can arise, including splenic rupture and secondary infections. Antiviral treatments are generally not indicated for infectious mononucleosis, as the condition is primarily managed with supportive care, including hydration, rest, and analgesics for pain relief. In severe cases, corticosteroids may be prescribed to reduce inflammation.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and symptom severity
  • Need for serological testing and interpretation of results
  • Potential for misdiagnosis with other conditions (e.g., strep throat, lymphoma)
  • Documentation of complications or coexisting conditions

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to document serological test results
  • Misclassification of the condition as a different viral infection
  • Lack of documentation for complications

Specialty Focus

Medical Specialties

Primary Care

Documentation Requirements

Detailed history of symptoms, physical examination findings, and results of diagnostic tests.

Common Clinical Scenarios

Patients presenting with fatigue, sore throat, and lymphadenopathy.

Billing Considerations

Ensure documentation reflects the clinical decision-making process and any differential diagnoses considered.

Infectious Disease

Documentation Requirements

Comprehensive evaluation of serological tests and management plans.

Common Clinical Scenarios

Patients with recurrent symptoms or complications from infectious mononucleosis.

Billing Considerations

Document any additional infectious workup or treatment plans, especially if complications arise.

Coding Guidelines

Inclusion Criteria

Use B27.1 When
  • According to ICD
  • 10 coding guidelines, B27
  • 1 should be used when the diagnosis of infectious mononucleosis is confirmed through clinical evaluation and serological testing

Exclusion Criteria

Do NOT use B27.1 When
  • Exclusion criteria include other viral infections that may present similarly but are not classified as infectious mononucleosis

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate lymphocyte counts in suspected infectious mononucleosis.

Documentation Requirements

Document the reason for the CBC and any abnormal findings.

Specialty Considerations

Primary care providers should ensure that the CBC results are linked to the diagnosis of infectious mononucleosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, improving the accuracy of data collection and reimbursement processes. The detailed coding helps in tracking the epidemiology of the disease and its complications more effectively.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, improving the accuracy of data collection and reimbursement processes. The detailed coding helps in tracking the epidemiology of the disease and its complications more effectively.

Reimbursement & Billing Impact

reimbursement processes. The detailed coding helps in tracking the epidemiology of the disease and its complications more effectively.

Resources

Clinical References

  • •
    CDC - Infectious Mononucleosis

Coding & Billing References

  • •
    CDC - Infectious Mononucleosis

Frequently Asked Questions

What are the common symptoms of infectious mononucleosis?

Common symptoms include fever, sore throat, swollen lymph nodes, fatigue, and sometimes rash. Symptoms can vary in severity and duration.

How is infectious mononucleosis diagnosed?

Diagnosis is typically made through clinical evaluation and serological tests, including the Monospot test and specific EBV antibody tests.

What treatments are available for infectious mononucleosis?

Treatment is primarily supportive, focusing on rest, hydration, and pain relief. Antiviral medications are not typically indicated.