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ICD-10 Guide
ICD-10 CodesB27.81

B27.81

Other infectious mononucleosis with polyneuropathy

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.81 is a billable code used to indicate a diagnosis of other infectious mononucleosis with polyneuropathy.

Key Diagnostic Point:

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), but other viral agents such as cytomegalovirus (CMV) and human immunodeficiency virus (HIV) can also lead to similar presentations. The condition is characterized by fever, sore throat, lymphadenopathy, and fatigue. In some cases, patients may develop polyneuropathy, which is a disorder affecting multiple peripheral nerves, leading to symptoms such as weakness, numbness, and pain. The pathophysiology of polyneuropathy in infectious mononucleosis may involve immune-mediated mechanisms or direct viral effects on nerve tissues. Diagnosis typically involves serological tests for specific antibodies (e.g., heterophile antibodies, EBV-specific antibodies) and may include nerve conduction studies to assess the extent of neuropathy. Treatment is generally supportive, focusing on symptom relief, but antiviral medications may be considered in severe cases or when caused by specific viral infections. The prognosis is generally good, with most patients recovering fully, although some may experience lingering symptoms.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between various viral causes of mononucleosis
  • Identifying and documenting polyneuropathy symptoms
  • Understanding the overlap with other infectious diseases
  • Need for comprehensive serological testing results

Audit Risk Factors

  • Inadequate documentation of polyneuropathy symptoms
  • Failure to specify the viral cause of mononucleosis
  • Misclassification of the condition as a non-infectious etiology
  • Lack of supporting lab results for diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of symptoms, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients presenting with fever, fatigue, and lymphadenopathy, especially in young adults.

Billing Considerations

Need to document the specific viral etiology and any neurological symptoms.

Neurology

Documentation Requirements

Neurological examination findings, nerve conduction study results, and treatment response.

Common Clinical Scenarios

Patients with unexplained neuropathy following a viral infection.

Billing Considerations

Documentation of the relationship between infectious mononucleosis and neurological symptoms is crucial.

Coding Guidelines

Inclusion Criteria

Use B27.81 When
  • According to ICD
  • 10 coding guidelines, B27
  • 81 should be used when polyneuropathy is specifically documented in conjunction with infectious mononucleosis
  • Coders must ensure that the documentation supports the diagnosis and that all relevant tests are included

Exclusion Criteria

Do NOT use B27.81 When
No specific exclusions found.

Related CPT Codes

86790CPT Code

EBV antibody test

Clinical Scenario

Used to confirm EBV infection in suspected cases of mononucleosis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing is performed.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like infectious mononucleosis with polyneuropathy, improving data accuracy and enhancing the ability to track disease patterns.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like infectious mononucleosis with polyneuropathy, improving data accuracy and enhancing the ability to track disease patterns.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions like infectious mononucleosis with polyneuropathy, improving data accuracy and enhancing the ability to track disease patterns.

Resources

Clinical References

  • •
    CDC - Infectious Mononucleosis

Coding & Billing References

  • •
    CDC - Infectious Mononucleosis

Frequently Asked Questions

What are the common symptoms of infectious mononucleosis?

Common symptoms include fever, sore throat, swollen lymph nodes, fatigue, and in some cases, neurological symptoms such as weakness or numbness.

How is polyneuropathy diagnosed in patients with infectious mononucleosis?

Polyneuropathy is diagnosed through clinical evaluation, nerve conduction studies, and by ruling out other potential causes of neuropathy.