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v1.0.0
ICD-10 Guide
ICD-10 CodesB27.89

B27.89

Other infectious mononucleosis with other complication

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.89 is a billable code used to indicate a diagnosis of other infectious mononucleosis with other complication.

Key Diagnostic Point:

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), but other viral agents such as cytomegalovirus (CMV) and human immunodeficiency virus (HIV) can also lead to similar clinical presentations. The condition is characterized by fever, sore throat, lymphadenopathy, and fatigue. In cases coded as B27.89, patients may experience complications such as splenic rupture, hepatitis, or secondary infections. Diagnosis typically involves serological tests for heterophile antibodies (Monospot test), EBV-specific antibodies, and complete blood counts showing atypical lymphocytes. Antiviral treatments are generally not indicated for EBV, but supportive care is crucial. In cases where CMV is the causative agent, antiviral medications like ganciclovir may be used. Accurate coding requires thorough documentation of the specific viral etiology and any complications that arise, as these can significantly impact treatment and management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between various viral causes of mononucleosis.
  • Identifying and documenting complications accurately.
  • Understanding the nuances of serological testing results.
  • Navigating the overlap with other infectious diseases.

Audit Risk Factors

  • Inadequate documentation of complications.
  • Failure to specify the viral etiology.
  • Misinterpretation of serological test results.
  • Linkage errors between diagnosis and treatment.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on the patient's history, examination findings, and laboratory results.

Common Clinical Scenarios

Patients presenting with fever, lymphadenopathy, and fatigue, requiring differential diagnosis.

Billing Considerations

Documentation must clearly state the viral cause and any complications to support the use of B27.89.

Primary Care

Documentation Requirements

Comprehensive patient history and physical examination notes, including symptom duration and severity.

Common Clinical Scenarios

Initial evaluation of suspected mononucleosis in adolescents and young adults.

Billing Considerations

Primary care providers should ensure follow-up documentation reflects any complications or changes in the patient's condition.

Coding Guidelines

Inclusion Criteria

Use B27.89 When
  • According to ICD
  • 10 guidelines, B27
  • 89 should be used when infectious mononucleosis is confirmed with complications that are not specified elsewhere
  • Coders must ensure that the documentation supports the diagnosis and any complications

Exclusion Criteria

Do NOT use B27.89 When
No specific exclusions found.

Related CPT Codes

86790CPT Code

EBV antibody test

Clinical Scenario

Used to confirm EBV infection in suspected cases of mononucleosis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists may require additional serological tests.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of complications and outcomes. B27.89 provides a mechanism to capture cases with additional complexities.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of complications and outcomes. B27.89 provides a mechanism to capture cases with additional complexities.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of complications and outcomes. B27.89 provides a mechanism to capture cases with additional complexities.

Resources

Clinical References

  • •
    CDC Infectious Mononucleosis Overview

Coding & Billing References

  • •
    CDC Infectious Mononucleosis Overview

Frequently Asked Questions

What are the common complications associated with B27.89?

Common complications include splenic rupture, hepatitis, and secondary infections, which must be documented to support the use of this code.