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ICD-10 Guide
ICD-10 CodesB27.90

B27.90

Infectious mononucleosis, unspecified without complication

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.90 is a billable code used to indicate a diagnosis of infectious mononucleosis, unspecified without complication.

Key Diagnostic Point:

Infectious mononucleosis, commonly referred to as mono, is primarily caused by the Epstein-Barr virus (EBV), a member of the herpesvirus family. It is characterized by fever, sore throat, swollen lymph nodes, and fatigue. The condition is often diagnosed in adolescents and young adults, although it can occur at any age. The diagnosis is typically made based on clinical presentation and confirmed through laboratory tests, including heterophile antibody tests (such as the Monospot test) and specific EBV serologies. While most cases are self-limiting, complications can arise, such as splenic rupture or secondary infections, although these are not included in this code. Treatment is generally supportive, focusing on symptom relief, as there are no specific antiviral medications approved for treating mono. Patients are advised to rest, stay hydrated, and manage pain with over-the-counter analgesics. Understanding the nuances of this condition is crucial for accurate coding and billing, especially in differentiating it from other similar viral infections.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation among patients
  • Need for laboratory confirmation of diagnosis
  • Differentiation from other viral infections (e.g., cytomegalovirus)
  • Potential for complications that may require different coding

Audit Risk Factors

  • Inadequate documentation of symptoms
  • Failure to include laboratory test results
  • Misdiagnosis with other viral infections
  • Lack of follow-up documentation

Specialty Focus

Medical Specialties

Primary Care

Documentation Requirements

Detailed patient history, physical examination findings, and laboratory test results.

Common Clinical Scenarios

Patients presenting with fatigue, sore throat, and lymphadenopathy.

Billing Considerations

Ensure that all symptoms and test results are documented to support the diagnosis.

Infectious Disease

Documentation Requirements

Comprehensive evaluation of patient history, including exposure history and serological testing.

Common Clinical Scenarios

Patients with atypical presentations or those requiring further evaluation for complications.

Billing Considerations

Consideration of differential diagnoses and potential co-infections.

Coding Guidelines

Inclusion Criteria

Use B27.90 When
  • According to ICD
  • 10 coding guidelines, B27
  • 90 should be used when the diagnosis of infectious mononucleosis is confirmed without any documented complications
  • Coders should ensure that the diagnosis is supported by clinical findings and laboratory results

Exclusion Criteria

Do NOT use B27.90 When
No specific exclusions found.

Related CPT Codes

86308CPT Code

EBV antibody test

Clinical Scenario

Used to confirm the diagnosis of infectious mononucleosis.

Documentation Requirements

Document the reason for the test and the results.

Specialty Considerations

Ensure that the test is ordered based on clinical suspicion.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of the condition and its complications. B27.90 provides a clear designation for cases without complications, improving data accuracy.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of the condition and its complications. B27.90 provides a clear designation for cases without complications, improving data accuracy.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, enabling better tracking of the condition and its complications. B27.90 provides a clear designation for cases without complications, improving data accuracy.

Resources

Clinical References

  • •
    CDC Infectious Mononucleosis Information

Coding & Billing References

  • •
    CDC Infectious Mononucleosis Information

Frequently Asked Questions

What are the common symptoms of infectious mononucleosis?

Common symptoms include fever, sore throat, swollen lymph nodes, and fatigue. Some patients may also experience headaches, rash, and loss of appetite.

How is infectious mononucleosis diagnosed?

Diagnosis is typically made based on clinical symptoms and confirmed through laboratory tests, including the Monospot test and specific EBV serologies.

What is the treatment for infectious mononucleosis?

Treatment is primarily supportive, focusing on rest, hydration, and pain management with over-the-counter medications. There are no specific antiviral treatments for mono.