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ICD-10 Guide
ICD-10 CodesB27.92

B27.92

Infectious mononucleosis, unspecified with meningitis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B27.92 is a billable code used to indicate a diagnosis of infectious mononucleosis, unspecified with meningitis.

Key Diagnostic Point:

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), a member of the herpes virus family. It is characterized by fever, sore throat, swollen lymph nodes, and fatigue. When this condition is complicated by meningitis, it indicates inflammation of the protective membranes covering the brain and spinal cord, which can lead to serious neurological complications. The diagnosis of infectious mononucleosis is typically made through clinical evaluation and serological tests, including heterophile antibody tests (e.g., Monospot test) and specific EBV antibody tests. In cases where meningitis is suspected, lumbar puncture may be performed to analyze cerebrospinal fluid (CSF) for signs of infection and inflammation. Antiviral treatments, such as acyclovir, may be considered in severe cases, although supportive care remains the mainstay of treatment. The presence of meningitis necessitates careful monitoring and management to prevent complications such as seizures or long-term neurological deficits.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiating between viral and bacterial meningitis
  • Need for comprehensive documentation of symptoms and diagnostic tests
  • Potential for overlapping symptoms with other viral infections
  • Variability in clinical presentation among patients

Audit Risk Factors

  • Inadequate documentation of clinical findings
  • Failure to specify the type of meningitis
  • Misinterpretation of laboratory results
  • Inconsistent coding of related symptoms

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed history of symptoms, laboratory test results, and treatment plans.

Common Clinical Scenarios

Patients presenting with fever, lymphadenopathy, and neurological symptoms.

Billing Considerations

Ensure clarity in distinguishing between viral and bacterial causes of meningitis.

Neurology

Documentation Requirements

Neurological examination findings, imaging studies, and CSF analysis results.

Common Clinical Scenarios

Patients with altered mental status or neurological deficits associated with infectious mononucleosis.

Billing Considerations

Document any neurological assessments and interventions performed.

Coding Guidelines

Inclusion Criteria

Use B27.92 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the condition and any associated complications
  • Include all relevant clinical findings and diagnostic tests

Exclusion Criteria

Do NOT use B27.92 When
No specific exclusions found.

Related CPT Codes

87491CPT Code

EBV antibody test

Clinical Scenario

Used to confirm the diagnosis of infectious mononucleosis.

Documentation Requirements

Document the reason for the test and the clinical findings leading to the suspicion of mononucleosis.

Specialty Considerations

Infectious disease specialists should ensure comprehensive testing for differential diagnoses.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 allows for more specific coding of infectious mononucleosis and its complications, improving data accuracy and facilitating better patient management.

ICD-9 vs ICD-10

The transition to ICD-10 allows for more specific coding of infectious mononucleosis and its complications, improving data accuracy and facilitating better patient management.

Reimbursement & Billing Impact

The transition to ICD-10 allows for more specific coding of infectious mononucleosis and its complications, improving data accuracy and facilitating better patient management.

Resources

Clinical References

  • •
    CDC - Infectious Mononucleosis

Coding & Billing References

  • •
    CDC - Infectious Mononucleosis

Frequently Asked Questions

What are the common symptoms of infectious mononucleosis?

Common symptoms include fever, sore throat, swollen lymph nodes, fatigue, and sometimes rash. In cases with meningitis, additional symptoms may include headache, neck stiffness, and altered mental status.