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ICD-10 Guide
ICD-10 CodesB30.3

B30.3

Infectious mononucleosis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B30.3 is a billable code used to indicate a diagnosis of infectious mononucleosis.

Key Diagnostic Point:

Infectious mononucleosis, commonly known as mono, is primarily caused by the Epstein-Barr virus (EBV), a member of the herpesvirus family. It is characterized by fever, sore throat, swollen lymph nodes, and fatigue. The virus is typically transmitted through saliva, which is why it is often referred to as the 'kissing disease.' Diagnosis is usually made based on clinical presentation and confirmed through laboratory tests, including heterophile antibody tests (such as the Monospot test) and specific EBV serologies. The condition is most prevalent among adolescents and young adults, although it can occur at any age. While most cases are self-limiting, complications such as splenic rupture or secondary infections can occur. Treatment is primarily supportive, focusing on symptom relief, as there are no specific antiviral therapies approved for EBV. Corticosteroids may be used in severe cases to reduce inflammation.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation among patients
  • Need for laboratory confirmation of diagnosis
  • Potential for misdiagnosis with other conditions
  • Documentation of symptoms and laboratory results

Audit Risk Factors

  • Inadequate documentation of symptoms
  • Failure to include laboratory test results
  • Misclassification of the condition
  • Lack of follow-up documentation

Specialty Focus

Medical Specialties

Primary Care

Documentation Requirements

Detailed history of symptoms, physical examination findings, and laboratory test results.

Common Clinical Scenarios

Patients presenting with fatigue, sore throat, and lymphadenopathy.

Billing Considerations

Ensure thorough documentation of differential diagnoses to support the coding of B30.3.

Infectious Disease

Documentation Requirements

Comprehensive evaluation of patient history, serological testing, and management plans.

Common Clinical Scenarios

Patients with recurrent symptoms or complications related to EBV infection.

Billing Considerations

Document any complications or co-infections that may affect treatment and coding.

Coding Guidelines

Inclusion Criteria

Use B30.3 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation and laboratory results
  • 3 should be used when the diagnosis of infectious mononucleosis is confirmed

Exclusion Criteria

Do NOT use B30.3 When
No specific exclusions found.

Related CPT Codes

86308CPT Code

EBV serology

Clinical Scenario

Used to confirm diagnosis of infectious mononucleosis.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists may require additional serological tests.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of infectious mononucleosis, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    CDC - Infectious Mononucleosis

Coding & Billing References

  • •
    CDC - Infectious Mononucleosis

Frequently Asked Questions

What is the primary cause of infectious mononucleosis?

Infectious mononucleosis is primarily caused by the Epstein-Barr virus (EBV), which is transmitted through saliva.