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ICD-10 Guide
ICD-10 CodesB45.8

B45.8

Cryptococcosis, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B45.8 is a billable code used to indicate a diagnosis of cryptococcosis, unspecified.

Key Diagnostic Point:

Cryptococcosis is a fungal infection caused by the Cryptococcus species, primarily Cryptococcus neoformans and Cryptococcus gattii. This infection is particularly significant in immunocompromised patients, such as those with HIV/AIDS, organ transplant recipients, or individuals on immunosuppressive therapy. The fungus is typically acquired through inhalation of airborne spores found in soil, particularly in areas with bird droppings. Symptoms can range from mild respiratory issues to severe neurological complications, including meningitis. Diagnosis is often made through culture, serological tests, or imaging studies. Treatment typically involves antifungal medications such as amphotericin B and flucytosine, followed by maintenance therapy with fluconazole. The unspecified nature of this code indicates that the specific manifestation or site of infection is not documented, which can complicate treatment and management strategies.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and severity of infection
  • Need for detailed patient history to determine immunocompromised status
  • Potential for co-infections with other pathogens
  • Documentation of antifungal treatment response and side effects

Audit Risk Factors

  • Inadequate documentation of immunocompromised status
  • Failure to specify the site of infection
  • Lack of clarity on treatment response
  • Misclassification of the infection type

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, laboratory results, and treatment plans.

Common Clinical Scenarios

Patients presenting with respiratory symptoms or meningitis in immunocompromised individuals.

Billing Considerations

Ensure documentation reflects the patient's immune status and any co-morbid conditions.

Pulmonology

Documentation Requirements

Pulmonary function tests, imaging studies, and treatment response.

Common Clinical Scenarios

Patients with respiratory distress or chronic cough with a history of exposure to potential sources of Cryptococcus.

Billing Considerations

Document any differential diagnoses and the rationale for antifungal therapy.

Coding Guidelines

Inclusion Criteria

Use B45.8 When
  • Follow official ICD
  • 10 coding guidelines for infectious diseases, ensuring accurate documentation of the patient's immune status and any related conditions

Exclusion Criteria

Do NOT use B45.8 When
  • Exclude codes for other fungal infections unless specified

Related CPT Codes

87481CPT Code

Cryptococcus antigen test

Clinical Scenario

Used to confirm diagnosis in suspected cryptococcosis cases.

Documentation Requirements

Document the reason for testing and results.

Specialty Considerations

Infectious disease specialists should ensure comprehensive documentation of clinical findings.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in various patient populations.

Resources

Clinical References

  • •
    CDC Fungal Diseases

Coding & Billing References

  • •
    CDC Fungal Diseases

Frequently Asked Questions

What are the common symptoms of cryptococcosis?

Common symptoms include cough, fever, chest pain, headache, and altered mental status, particularly in immunocompromised patients.

How is cryptococcosis diagnosed?

Diagnosis is typically made through culture, serological tests for cryptococcal antigen, and imaging studies to assess for pulmonary or CNS involvement.

What antifungal treatments are used for cryptococcosis?

First-line treatments include amphotericin B and flucytosine, followed by maintenance therapy with fluconazole.

Why is immunocompromised status important in cryptococcosis?

Immunocompromised patients are at a higher risk for severe disease and complications, making accurate documentation of their status critical for treatment planning.