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v1.0.0
ICD-10 Guide
ICD-10 CodesB45.9

B45.9

Cryptococcosis, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B45.9 is a billable code used to indicate a diagnosis of cryptococcosis, unspecified.

Key Diagnostic Point:

Cryptococcosis is a fungal infection caused by the Cryptococcus species, primarily Cryptococcus neoformans and Cryptococcus gattii. This infection is particularly significant in immunocompromised patients, such as those with HIV/AIDS, organ transplant recipients, or individuals on immunosuppressive therapy. The fungus is typically acquired through inhalation of airborne spores found in soil, particularly in areas with bird droppings. Symptoms can range from mild respiratory issues to severe neurological complications, including meningitis. Diagnosis is often made through culture, serological tests, or imaging studies. Treatment typically involves antifungal medications such as amphotericin B and flucytosine, followed by maintenance therapy with fluconazole. The unspecified nature of this code indicates that the specific site of infection or severity is not documented, which can complicate treatment decisions and outcomes.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in clinical presentation and severity of the disease.
  • Need for detailed patient history to determine immunocompromised status.
  • Potential for co-infections that may complicate coding.
  • Documentation of antifungal treatment and response to therapy.

Audit Risk Factors

  • Inadequate documentation of immunocompromised status.
  • Failure to specify the site of infection.
  • Lack of clarity on treatment regimen and response.
  • Misclassification of the severity of the infection.

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed patient history, including immunocompromised status and treatment response.

Common Clinical Scenarios

Patients presenting with respiratory symptoms or neurological signs, particularly in immunocompromised individuals.

Billing Considerations

Ensure thorough documentation of antifungal therapy and any complications.

Pulmonology

Documentation Requirements

Pulmonary function tests and imaging studies to assess respiratory involvement.

Common Clinical Scenarios

Patients with chronic cough or pneumonia-like symptoms.

Billing Considerations

Document any underlying lung disease that may affect treatment.

Coding Guidelines

Inclusion Criteria

Use B45.9 When
  • Follow official ICD
  • 10 coding guidelines, ensuring accurate documentation of the patient's immunocompromised status and any related conditions
  • existing

Exclusion Criteria

Do NOT use B45.9 When
  • Exclude codes for other specific fungal infections unless co

Related CPT Codes

87481CPT Code

Cryptococcus neoformans antigen test

Clinical Scenario

Used to confirm diagnosis in suspected cases of cryptococcosis.

Documentation Requirements

Document the reason for testing and clinical findings.

Specialty Considerations

Infectious disease specialists should ensure comprehensive documentation.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in immunocompromised patients.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in immunocompromised patients.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of cryptococcosis, improving the ability to track and manage this infection in immunocompromised patients.

Resources

Clinical References

  • •
    CDC Fungal Diseases

Coding & Billing References

  • •
    CDC Fungal Diseases

Frequently Asked Questions

What is the significance of coding B45.9?

Coding B45.9 is crucial for tracking cryptococcosis cases, especially in immunocompromised patients, to ensure appropriate treatment and resource allocation.