ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesC21.1

C21.1

Billable

Malignant neoplasm of anal canal

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C21.1 is a billable code used to indicate a diagnosis of malignant neoplasm of anal canal.

Key Diagnostic Point:

Malignant neoplasm of the anal canal refers to cancer that originates in the tissues of the anal canal, which is the terminal part of the gastrointestinal tract. This type of cancer can arise from various cell types within the anal canal, including squamous cells, which are the most common. Risk factors include human papillomavirus (HPV) infection, smoking, and immunosuppression. Symptoms may include rectal bleeding, pain, and changes in bowel habits. Diagnosis typically involves a combination of physical examination, imaging studies, and biopsy. Staging of anal canal cancer is crucial for determining treatment options and prognosis, often utilizing the AJCC (American Joint Committee on Cancer) staging system. Treatment may involve surgery, radiation therapy, and chemotherapy, depending on the stage and specific characteristics of the tumor. Recent advances in understanding microsatellite instability (MSI) have also provided insights into the tumor's behavior and potential responsiveness to immunotherapy. Regular screening for anal cancer is recommended for high-risk populations, particularly those with a history of HPV-related diseases.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of histological types that can affect coding
  • Need for precise staging information
  • Potential for co-morbid conditions affecting treatment
  • Variability in treatment approaches based on tumor characteristics

Audit Risk Factors

  • Inadequate documentation of staging
  • Failure to document co-morbid conditions
  • Misclassification of tumor type
  • Lack of clarity in treatment plans

Specialty Focus

Medical Specialties

Oncology

Documentation Requirements

Detailed pathology reports, treatment plans, and follow-up notes are essential.

Common Clinical Scenarios

Management of newly diagnosed anal canal cancer, treatment planning for advanced disease.

Billing Considerations

Ensure accurate staging and documentation of treatment response.

Gastroenterology

Documentation Requirements

Endoscopy reports, biopsy results, and imaging studies must be included.

Common Clinical Scenarios

Screening high-risk patients, follow-up of patients with anal dysplasia.

Billing Considerations

Document any findings from colonoscopy or other diagnostic procedures.

Coding Guidelines

Inclusion Criteria

Use C21.1 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis, staging, and any associated procedures
  • Include specific details about the tumor type and treatment plan

Exclusion Criteria

Do NOT use C21.1 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

45385CPT Code

Endoscopic biopsy of anal canal

Clinical Scenario

Used when a biopsy is performed to confirm a diagnosis of anal canal cancer.

Documentation Requirements

Document the indication for the biopsy, findings, and pathology results.

Specialty Considerations

Oncologists and gastroenterologists should ensure clear communication regarding biopsy results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of anal canal cancers, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of treatment outcomes and epidemiological studies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of anal canal cancers, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of treatment outcomes and epidemiological studies.

Reimbursement & Billing Impact

reimbursement processes. This specificity aids in better tracking of treatment outcomes and epidemiological studies.

Resources

Clinical References

  • •
    American Cancer Society - Anal Cancer

Coding & Billing References

  • •
    American Cancer Society - Anal Cancer

Frequently Asked Questions

What are the common symptoms of anal canal cancer?

Common symptoms include rectal bleeding, pain, changes in bowel habits, and the presence of a lump near the anus.