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ICD-10 Guide
ICD-10 CodesC22.3

C22.3

Billable

Angiosarcoma of liver

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C22.3 is a billable code used to indicate a diagnosis of angiosarcoma of liver.

Key Diagnostic Point:

Angiosarcoma of the liver is a rare and aggressive form of cancer that originates from the endothelial cells lining the blood vessels of the liver. This malignancy is characterized by rapid growth and a tendency to metastasize early, often leading to a poor prognosis. Angiosarcoma can be associated with underlying liver conditions, particularly cirrhosis, which may predispose patients to the development of this cancer. The etiology of angiosarcoma can include exposure to certain chemicals, such as vinyl chloride and arsenic, as well as pre-existing liver diseases. Patients may present with symptoms such as abdominal pain, weight loss, and jaundice. Alpha-fetoprotein (AFP) levels can be elevated in some cases, although they are not specific to angiosarcoma and are more commonly associated with hepatocellular carcinoma. Treatment options may include surgical resection, liver transplantation, and chemotherapy, depending on the stage of the disease and the overall health of the liver. Given the aggressive nature of angiosarcoma, early diagnosis and intervention are critical for improving outcomes.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Rarity of the condition leading to limited coding experience
  • Association with cirrhosis complicating diagnosis and treatment
  • Variability in AFP levels complicating differential diagnosis
  • Need for precise documentation of staging and treatment options

Audit Risk Factors

  • Inadequate documentation of the diagnosis and staging
  • Misclassification of angiosarcoma as hepatocellular carcinoma
  • Failure to document associated liver conditions like cirrhosis
  • Inconsistent reporting of AFP levels

Specialty Focus

Medical Specialties

Oncology

Documentation Requirements

Detailed pathology reports, imaging studies, and treatment plans.

Common Clinical Scenarios

Diagnosis and management of liver tumors, including angiosarcoma.

Billing Considerations

Need for comprehensive documentation of tumor characteristics and treatment responses.

Hepatology

Documentation Requirements

Liver function tests, history of liver disease, and imaging results.

Common Clinical Scenarios

Management of patients with cirrhosis and liver tumors.

Billing Considerations

Documentation of cirrhosis severity and its impact on treatment decisions.

Coding Guidelines

Inclusion Criteria

Use C22.3 When
  • According to ICD
  • 10 coding guidelines, C22
  • 3 should be used when the diagnosis of angiosarcoma is confirmed through histopathological examination
  • It is essential to document any associated liver conditions, such as cirrhosis, and to follow the guidelines for coding malignancies, including staging and treatment details

Exclusion Criteria

Do NOT use C22.3 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

47120CPT Code

Liver resection

Clinical Scenario

Used when surgical intervention is required for angiosarcoma.

Documentation Requirements

Operative reports detailing the extent of resection.

Specialty Considerations

Oncology and hepatology must collaborate for optimal patient outcomes.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of angiosarcoma, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of treatment outcomes and resource allocation.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of angiosarcoma, improving the accuracy of data collection and reimbursement processes. This specificity aids in better tracking of treatment outcomes and resource allocation.

Reimbursement & Billing Impact

reimbursement processes. This specificity aids in better tracking of treatment outcomes and resource allocation.

Resources

Clinical References

  • •
    American Cancer Society - Angiosarcoma

Coding & Billing References

  • •
    American Cancer Society - Angiosarcoma

Frequently Asked Questions

What is the prognosis for patients with angiosarcoma of the liver?

The prognosis for angiosarcoma of the liver is generally poor due to its aggressive nature and tendency to metastasize. Early detection and treatment are crucial for improving outcomes.