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ICD-10 Guide
ICD-10 CodesC22.8

C22.8

Billable

Malignant neoplasm of liver, primary, unspecified as to type

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C22.8 is a billable code used to indicate a diagnosis of malignant neoplasm of liver, primary, unspecified as to type.

Key Diagnostic Point:

C22.8 refers to a primary malignant neoplasm of the liver that is unspecified as to type. This code encompasses various forms of liver cancer, including hepatocellular carcinoma (HCC) and other less common types. Liver cancer is often associated with underlying liver diseases, particularly cirrhosis, which can be caused by chronic hepatitis infections (B or C), alcohol abuse, or non-alcoholic fatty liver disease (NAFLD). The presence of alpha-fetoprotein (AFP) levels is a critical biomarker in diagnosing liver cancer; elevated AFP levels can indicate hepatocellular carcinoma, although they may not be elevated in all cases. Treatment options for liver cancer may include surgical resection, liver transplantation, and systemic therapies. Transplantation is particularly considered for patients with early-stage liver cancer and significant underlying liver disease, as it addresses both the malignancy and the cirrhosis. Accurate coding for C22.8 requires careful documentation of the type of liver cancer, associated liver conditions, and treatment plans.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in liver cancer types and their documentation
  • Need for correlation with cirrhosis and other liver diseases
  • Interpretation of AFP levels and their clinical significance
  • Consideration of treatment modalities and their documentation

Audit Risk Factors

  • Inadequate documentation of liver cancer type
  • Failure to document cirrhosis or other liver diseases
  • Misinterpretation of AFP levels
  • Lack of clarity on treatment plans

Specialty Focus

Medical Specialties

Hepatology

Documentation Requirements

Detailed history of liver disease, imaging results, and biopsy reports.

Common Clinical Scenarios

Patients with chronic hepatitis presenting with elevated AFP and imaging findings suggestive of liver tumors.

Billing Considerations

Ensure clear documentation of cirrhosis status and any prior treatments.

Oncology

Documentation Requirements

Pathology reports, staging information, and treatment plans.

Common Clinical Scenarios

Patients undergoing chemotherapy or considering liver transplantation for liver cancer.

Billing Considerations

Document the rationale for treatment choices and any multidisciplinary discussions.

Coding Guidelines

Inclusion Criteria

Use C22.8 When
  • According to ICD
  • 10 guidelines, C22
  • 8 should be used when the specific type of primary liver cancer is not documented
  • Coders must ensure that all relevant clinical information is captured to support the diagnosis

Exclusion Criteria

Do NOT use C22.8 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

47133CPT Code

Liver transplantation

Clinical Scenario

Used for patients with liver cancer and cirrhosis.

Documentation Requirements

Document indications for transplant and staging of cancer.

Specialty Considerations

Ensure multidisciplinary team notes are included.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of liver cancers, improving the granularity of data for treatment and research. C22.8 serves as a catch-all for unspecified types, highlighting the need for thorough documentation.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of liver cancers, improving the granularity of data for treatment and research. C22.8 serves as a catch-all for unspecified types, highlighting the need for thorough documentation.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of liver cancers, improving the granularity of data for treatment and research. C22.8 serves as a catch-all for unspecified types, highlighting the need for thorough documentation.

Resources

Clinical References

  • •
    American Cancer Society - Liver Cancer

Coding & Billing References

  • •
    American Cancer Society - Liver Cancer

Frequently Asked Questions

When should I use C22.8?

C22.8 should be used when the specific type of primary liver cancer is not documented, but there is a confirmed diagnosis of liver malignancy.