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ICD-10 Guide
ICD-10 CodesC75.8

C75.8

Billable

Malignant neoplasm with pluriglandular involvement, unspecified

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C75.8 is a billable code used to indicate a diagnosis of malignant neoplasm with pluriglandular involvement, unspecified.

Key Diagnostic Point:

C75.8 refers to malignant neoplasms that involve multiple endocrine glands without a specified site. These neoplasms can arise from various endocrine tissues, including the thyroid, adrenal glands, and pituitary gland, leading to complex clinical presentations. The involvement of multiple glands can result in dysregulation of hormone production, leading to metabolic disturbances and systemic effects. Patients may present with symptoms related to hypersecretion or hyposecretion of hormones, such as weight changes, fatigue, and alterations in glucose metabolism. The diagnosis often requires a combination of imaging studies, laboratory tests to assess hormone levels, and histopathological examination of tissue samples. Given the diverse nature of endocrine malignancies, treatment may involve surgery, radiation therapy, and systemic therapies, tailored to the specific glands involved and the type of malignancy. Accurate coding is essential for appropriate management and reimbursement, as well as for tracking epidemiological trends in endocrine cancers.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of potential primary sites and types of malignancies involved
  • Need for comprehensive documentation of multiple gland involvement
  • Differentiation from benign conditions and other malignancies
  • Potential for overlapping symptoms with other endocrine disorders

Audit Risk Factors

  • Insufficient documentation of gland involvement
  • Inconsistent hormone level assessments
  • Lack of clarity in treatment plans
  • Misidentification of the primary site of malignancy

Specialty Focus

Medical Specialties

Endocrinology

Documentation Requirements

Detailed documentation of hormone levels, imaging studies, and clinical symptoms.

Common Clinical Scenarios

Patients presenting with symptoms of hyperthyroidism or adrenal insufficiency.

Billing Considerations

Endocrinologists must ensure comprehensive documentation of all affected glands and associated symptoms.

Oncology

Documentation Requirements

Pathology reports, treatment plans, and follow-up assessments.

Common Clinical Scenarios

Patients undergoing treatment for multiple endocrine tumors.

Billing Considerations

Oncologists should document the specific type of malignancy and its impact on hormone function.

Coding Guidelines

Inclusion Criteria

Use C75.8 When
  • Follow official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation
  • 8 should be used when multiple glands are involved, and no specific gland is identified
  • Ensure to document any relevant lab results and imaging studies

Exclusion Criteria

Do NOT use C75.8 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

88305CPT Code

Pathology examination of tissue

Clinical Scenario

Used when a biopsy is performed to confirm malignancy.

Documentation Requirements

Pathology report must be included in the patient's medical record.

Specialty Considerations

Endocrinologists and oncologists should ensure that the pathology report clearly indicates malignancy.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of complex conditions like C75.8, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of epidemiological trends in endocrine malignancies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of complex conditions like C75.8, improving the accuracy of data collection and reimbursement processes. It has also facilitated better tracking of epidemiological trends in endocrine malignancies.

Reimbursement & Billing Impact

reimbursement processes. It has also facilitated better tracking of epidemiological trends in endocrine malignancies.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What is the significance of coding C75.8?

C75.8 is significant as it captures the complexity of malignant neoplasms involving multiple endocrine glands, which can have varied clinical implications and treatment pathways.