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ICD-10 Guide
ICD-10 CodesC82.48

C82.48

Billable

Follicular lymphoma grade IIIb, lymph nodes of multiple sites

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C82.48 is a billable code used to indicate a diagnosis of follicular lymphoma grade iiib, lymph nodes of multiple sites.

Key Diagnostic Point:

Follicular lymphoma is a type of non-Hodgkin lymphoma characterized by the proliferation of follicle center (germinal center) B-cells. Grade IIIb indicates a more aggressive form of the disease, where more than 50% of the neoplastic cells are large cells, which can lead to a more rapid progression and poorer prognosis compared to lower grades. This specific code, C82.48, is used when the lymphoma is present in lymph nodes at multiple sites, indicating systemic involvement. Patients may present with B-symptoms, which include fever, night sweats, and weight loss, and may require staging through imaging studies such as PET scans or CT scans to assess the extent of the disease. Treatment protocols often involve chemotherapy regimens, immunotherapy, or targeted therapies, and may include the use of monoclonal antibodies like rituximab. The management of follicular lymphoma is complex and requires a multidisciplinary approach, including oncologists, hematologists, and radiologists, to ensure optimal patient outcomes.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Differentiation between grades of follicular lymphoma
  • Staging requirements and imaging documentation
  • Presence of B-symptoms affecting treatment decisions
  • Multisite involvement complicating coding

Audit Risk Factors

  • Inadequate documentation of staging and imaging results
  • Failure to document B-symptoms
  • Misclassification of lymphoma grade
  • Inconsistent treatment documentation

Specialty Focus

Medical Specialties

Hematology/Oncology

Documentation Requirements

Comprehensive documentation of diagnosis, staging, treatment plans, and follow-up care.

Common Clinical Scenarios

Patients presenting with lymphadenopathy, B-symptoms, or those undergoing chemotherapy.

Billing Considerations

Ensure accurate grading and staging are documented to support the coding of C82.48.

Radiology

Documentation Requirements

Detailed imaging reports that specify the number and locations of affected lymph nodes.

Common Clinical Scenarios

Imaging studies performed for staging or monitoring treatment response.

Billing Considerations

Radiology reports must clearly indicate the extent of lymph node involvement to support coding.

Coding Guidelines

Inclusion Criteria

Use C82.48 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the diagnosis is supported by clinical documentation
  • Include details on the grade of lymphoma, staging, and any associated symptoms

Exclusion Criteria

Do NOT use C82.48 When
  • Exclude codes that do not accurately reflect the patient's condition

Related ICD-10 Codes

Related CPT Codes

96413CPT Code

Chemotherapy administration, intravenous

Clinical Scenario

Used when administering chemotherapy for follicular lymphoma grade IIIb.

Documentation Requirements

Document the specific chemotherapy regimen and patient response.

Specialty Considerations

Oncology specialists must ensure accurate coding of chemotherapy administration.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of follicular lymphoma, including differentiation by grade and site. This specificity improves the accuracy of patient records and treatment planning.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of follicular lymphoma, including differentiation by grade and site. This specificity improves the accuracy of patient records and treatment planning.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of follicular lymphoma, including differentiation by grade and site. This specificity improves the accuracy of patient records and treatment planning.

Resources

Clinical References

  • •
    National Comprehensive Cancer Network (NCCN) Guidelines

Coding & Billing References

  • •
    National Comprehensive Cancer Network (NCCN) Guidelines

Frequently Asked Questions

What are the key symptoms of follicular lymphoma grade IIIb?

Key symptoms include lymphadenopathy, B-symptoms such as fever, night sweats, and weight loss, and fatigue. These symptoms can indicate disease progression and influence treatment decisions.