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v1.0.0
ICD-10 Guide
ICD-10 CodesC82.58

C82.58

Billable

Diffuse follicle center lymphoma, lymph nodes of multiple sites

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C82.58 is a billable code used to indicate a diagnosis of diffuse follicle center lymphoma, lymph nodes of multiple sites.

Key Diagnostic Point:

Diffuse follicle center lymphoma (DFCL) is a subtype of non-Hodgkin lymphoma characterized by the proliferation of neoplastic B-cells in the follicle center of lymphoid tissue. This condition typically presents with enlarged lymph nodes in multiple anatomical sites, which may include cervical, axillary, and inguinal regions. Patients may exhibit B-symptoms such as fever, night sweats, and unexplained weight loss, indicating systemic involvement. The diagnosis is confirmed through histopathological examination of lymph node biopsies, which reveal a diffuse pattern of follicle center cell proliferation. Staging of DFCL is crucial for determining prognosis and treatment strategies, often utilizing the Ann Arbor staging system. Treatment protocols may include chemotherapy regimens, monoclonal antibody therapy, and in some cases, stem cell transplantation, depending on the stage and patient’s overall health. Regular follow-up and monitoring for treatment response and potential complications are essential components of patient management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Requires understanding of lymphoma subtypes and their characteristics.
  • Involves knowledge of staging systems and B-symptoms.
  • Documentation must specify multiple lymph node involvement.
  • Differentiation from other lymphoma types is necessary.

Audit Risk Factors

  • Inadequate documentation of lymph node sites.
  • Failure to document B-symptoms.
  • Incorrect staging leading to inappropriate treatment coding.
  • Misclassification of lymphoma subtype.

Specialty Focus

Medical Specialties

Hematology/Oncology

Documentation Requirements

Detailed pathology reports, staging information, and treatment plans.

Common Clinical Scenarios

Initial diagnosis, treatment planning, and follow-up care for lymphoma patients.

Billing Considerations

Ensure accurate coding of treatment modalities and response assessments.

Pathology

Documentation Requirements

Comprehensive biopsy reports and histological findings.

Common Clinical Scenarios

Biopsy interpretation and staging of lymphomas.

Billing Considerations

Clear documentation of histological subtype is critical for accurate coding.

Coding Guidelines

Inclusion Criteria

Use C82.58 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the diagnosis, staging, and treatment
  • Include specific details about lymph node involvement and any associated symptoms

Exclusion Criteria

Do NOT use C82.58 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85041CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used for monitoring blood counts during treatment.

Documentation Requirements

Document the reason for CBC and any abnormalities noted.

Specialty Considerations

Hematology specialists should ensure accurate interpretation of results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of lymphoma subtypes, improving the accuracy of data collection and reimbursement processes. C82.58 provides a clear distinction for diffuse follicle center lymphoma, which aids in treatment planning and epidemiological studies.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of lymphoma subtypes, improving the accuracy of data collection and reimbursement processes. C82.58 provides a clear distinction for diffuse follicle center lymphoma, which aids in treatment planning and epidemiological studies.

Reimbursement & Billing Impact

reimbursement processes. C82.58 provides a clear distinction for diffuse follicle center lymphoma, which aids in treatment planning and epidemiological studies.

Resources

Clinical References

  • •
    American Cancer Society - Lymphoma

Coding & Billing References

  • •
    American Cancer Society - Lymphoma

Frequently Asked Questions

What are the common symptoms of diffuse follicle center lymphoma?

Common symptoms include swollen lymph nodes, fever, night sweats, and unexplained weight loss. Patients may also experience fatigue and other systemic symptoms.