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v1.0.0
ICD-10 Guide
ICD-10 CodesC82.59

C82.59

Billable

Diffuse follicle center lymphoma, extranodal and solid organ sites

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 C82.59 is a billable code used to indicate a diagnosis of diffuse follicle center lymphoma, extranodal and solid organ sites.

Key Diagnostic Point:

Diffuse follicle center lymphoma (DFCL) is a subtype of non-Hodgkin lymphoma characterized by the proliferation of neoplastic B-cells that originate from the germinal centers of lymphoid follicles. This specific code, C82.59, refers to cases where the lymphoma manifests in extranodal sites or solid organs, which can include the gastrointestinal tract, skin, or other organs outside of the lymphatic system. Clinically, patients may present with a variety of symptoms, including lymphadenopathy, splenomegaly, and B-symptoms such as fever, night sweats, and weight loss. The diagnosis is typically confirmed through histopathological examination and immunophenotyping. Staging of DFCL is crucial for determining the prognosis and treatment approach, which may include chemotherapy, immunotherapy, or radiation therapy, depending on the extent of the disease and patient-specific factors. The management of DFCL requires a multidisciplinary approach, often involving oncologists, hematologists, and radiologists.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in presentation and staging of lymphoma
  • Need for precise documentation of extranodal involvement
  • Differentiation from other lymphoma subtypes
  • Potential for overlapping symptoms with other conditions

Audit Risk Factors

  • Inadequate documentation of extranodal involvement
  • Failure to specify the site of the lymphoma
  • Misclassification of lymphoma subtype
  • Lack of supporting pathology reports

Specialty Focus

Medical Specialties

Hematology/Oncology

Documentation Requirements

Comprehensive pathology reports, staging information, and treatment plans.

Common Clinical Scenarios

Diagnosis and management of patients presenting with lymphadenopathy and B-symptoms.

Billing Considerations

Ensure accurate documentation of treatment response and any complications.

Pathology

Documentation Requirements

Detailed histological findings and immunophenotyping results.

Common Clinical Scenarios

Evaluation of biopsy specimens from suspected lymphoma cases.

Billing Considerations

Clear communication of findings to support accurate coding.

Coding Guidelines

Inclusion Criteria

Use C82.59 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the lymphoma subtype and site of involvement
  • Include staging information and any relevant clinical findings

Exclusion Criteria

Do NOT use C82.59 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

88305CPT Code

Pathology examination, surgical

Clinical Scenario

Used when a biopsy is performed to confirm the diagnosis of DFCL.

Documentation Requirements

Pathology report detailing histological findings.

Specialty Considerations

Pathologists should ensure clear communication of findings to support accurate coding.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of lymphomas, including the ability to capture extranodal involvement, which is crucial for treatment planning and prognosis.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of lymphomas, including the ability to capture extranodal involvement, which is crucial for treatment planning and prognosis.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of lymphomas, including the ability to capture extranodal involvement, which is crucial for treatment planning and prognosis.

Resources

Clinical References

  • •
    American Cancer Society - Lymphoma

Coding & Billing References

  • •
    American Cancer Society - Lymphoma

Frequently Asked Questions

What are the common symptoms of diffuse follicle center lymphoma?

Common symptoms include lymphadenopathy, splenomegaly, and B-symptoms such as fever, night sweats, and unexplained weight loss.

How is diffuse follicle center lymphoma diagnosed?

Diagnosis typically involves a combination of imaging studies, laboratory tests, and histopathological evaluation of biopsy specimens.