ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesD59.13

D59.13

Billable

Mixed type autoimmune hemolytic anemia

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D59.13 is a billable code used to indicate a diagnosis of mixed type autoimmune hemolytic anemia.

Key Diagnostic Point:

Mixed type autoimmune hemolytic anemia (AIHA) is a hematological disorder characterized by the destruction of red blood cells (RBCs) due to the immune system mistakenly targeting them. This condition can be classified into two main types: warm AIHA, where antibodies react at body temperature, and cold AIHA, where antibodies react at lower temperatures. Patients may present with symptoms such as fatigue, pallor, jaundice, and splenomegaly. The mixed type indicates the presence of both warm and cold antibodies, complicating the clinical picture and management. Diagnosis typically involves laboratory tests including a complete blood count (CBC), reticulocyte count, direct Coombs test, and peripheral blood smear. Treatment may include corticosteroids, immunosuppressive agents, or splenectomy, depending on the severity and underlying causes. Genetic factors, such as certain enzyme deficiencies and hereditary conditions like thalassemia and sickle cell disease, can also contribute to the risk of developing hemolytic anemia, necessitating a comprehensive evaluation of the patient's history and genetic background.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Differentiation between warm and cold AIHA
  • Potential overlap with other hemolytic anemias
  • Need for comprehensive laboratory testing
  • Management may involve multiple specialties

Audit Risk Factors

  • Inadequate documentation of antibody types
  • Failure to document underlying conditions
  • Misclassification of hemolytic anemia type
  • Lack of supporting lab results

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, patient history, and treatment plans must be documented.

Common Clinical Scenarios

Diagnosis and management of AIHA, evaluation of hemolytic anemia in patients with autoimmune disorders.

Billing Considerations

Ensure clarity in distinguishing between warm and cold AIHA for accurate coding.

Rheumatology

Documentation Requirements

Documentation of autoimmune conditions and their relationship to hemolytic anemia.

Common Clinical Scenarios

Management of patients with autoimmune diseases presenting with hemolytic anemia.

Billing Considerations

Document any concurrent autoimmune disorders that may contribute to the condition.

Coding Guidelines

Inclusion Criteria

Use D59.13 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the type of autoimmune hemolytic anemia and any underlying conditions
  • Include relevant lab results and clinical findings to support the diagnosis

Exclusion Criteria

Do NOT use D59.13 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count with reticulocyte count

Clinical Scenario

Used to evaluate anemia in patients suspected of having AIHA.

Documentation Requirements

Document the reason for the CBC and reticulocyte count, including symptoms and clinical findings.

Specialty Considerations

Hematologists should ensure comprehensive lab results are included.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of mixed type autoimmune hemolytic anemia, improving the accuracy of diagnosis and treatment tracking.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of mixed type autoimmune hemolytic anemia, improving the accuracy of diagnosis and treatment tracking.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of mixed type autoimmune hemolytic anemia, improving the accuracy of diagnosis and treatment tracking.

Resources

Clinical References

  • •
    American Society of Hematology

Coding & Billing References

  • •
    American Society of Hematology

Frequently Asked Questions

What are the common symptoms of mixed type autoimmune hemolytic anemia?

Common symptoms include fatigue, pallor, jaundice, and splenomegaly, which result from the destruction of red blood cells.

How is mixed type autoimmune hemolytic anemia diagnosed?

Diagnosis is made through clinical evaluation, laboratory tests including CBC, reticulocyte count, and direct Coombs test.