Other drug-induced pancytopenia
ICD-10 D61.811 is a billable code used to indicate a diagnosis of other drug-induced pancytopenia.
Drug-induced pancytopenia is a hematological condition characterized by a reduction in red blood cells, white blood cells, and platelets due to the adverse effects of certain medications. This condition can arise from various drug classes, including antibiotics, antiepileptics, and chemotherapeutic agents. Aplastic anemia, a severe form of bone marrow failure, can be a consequence of drug-induced damage to hematopoietic stem cells, leading to a significant decrease in blood cell production. Patients may present with symptoms such as fatigue, increased susceptibility to infections, and bleeding tendencies due to thrombocytopenia. Diagnosis typically involves a complete blood count (CBC), bone marrow biopsy, and exclusion of other causes of pancytopenia. Management includes discontinuation of the offending drug, supportive care, and in severe cases, immunosuppressive therapy or bone marrow transplantation. Understanding the underlying mechanisms of drug-induced bone marrow suppression is crucial for effective diagnosis and treatment.
Detailed patient history, including medication list and duration of use, lab results, and clinical symptoms.
Patients presenting with unexplained anemia, leukopenia, or thrombocytopenia after starting new medications.
Ensure clear documentation of the timeline between drug exposure and onset of symptoms.
Comprehensive treatment history, including chemotherapy regimens and supportive care measures.
Patients undergoing chemotherapy who develop cytopenias.
Document the specific chemotherapy agents used and their known side effects.
Used to evaluate patients with suspected pancytopenia.
Document the indication for the CBC and any relevant clinical findings.
Hematologists should ensure that the CBC results are interpreted in the context of the patient's medication history.
Common drugs include certain antibiotics (like chloramphenicol), antiepileptics (like carbamazepine), and chemotherapeutic agents. It's essential to review the patient's medication history to identify potential causes.
