ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesD68.59

D68.59

Billable

Other primary thrombophilia

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D68.59 is a billable code used to indicate a diagnosis of other primary thrombophilia.

Key Diagnostic Point:

Primary thrombophilia refers to a group of inherited or acquired conditions that increase the risk of thrombosis due to abnormalities in the coagulation system. D68.59 specifically encompasses cases of thrombophilia that do not fall under more specific categories, such as Factor V Leiden or prothrombin gene mutation. Patients with primary thrombophilia may experience recurrent venous thromboembolism (VTE), which can lead to serious complications such as pulmonary embolism or post-thrombotic syndrome. The condition is often asymptomatic until a thrombotic event occurs, making early diagnosis challenging. Coagulation defects associated with primary thrombophilia can include deficiencies in natural anticoagulants like protein C, protein S, and antithrombin III. These defects can lead to an imbalance in the coagulation cascade, resulting in excessive clot formation. Bleeding disorders, such as hemophilia or thrombocytopenia, may coexist but are distinct from thrombophilia. Management typically involves anticoagulation therapy, lifestyle modifications, and monitoring for thrombotic events. Accurate coding is essential for proper treatment and reimbursement, as well as for tracking epidemiological data on thrombophilia.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying causes and conditions that can lead to primary thrombophilia.
  • Need for detailed patient history to determine the specific type of thrombophilia.
  • Potential overlap with other coagulation disorders, complicating diagnosis.
  • Variability in clinical presentation and management strategies.

Audit Risk Factors

  • Inadequate documentation of the specific type of thrombophilia.
  • Failure to document the patient's history of thrombotic events.
  • Misclassification of primary thrombophilia as secondary thrombophilia.
  • Lack of supporting lab results or genetic testing documentation.

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed patient history, lab results, and treatment plans.

Common Clinical Scenarios

Patients presenting with recurrent VTE, family history of thrombosis, or abnormal coagulation profiles.

Billing Considerations

Ensure that all relevant lab tests (e.g., genetic testing, protein levels) are documented to support the diagnosis.

Internal Medicine

Documentation Requirements

Comprehensive assessment of risk factors and management strategies.

Common Clinical Scenarios

Management of patients with known thrombophilia undergoing surgery or other high-risk procedures.

Billing Considerations

Coordination with hematology for complex cases and ensuring continuity of care.

Coding Guidelines

Inclusion Criteria

Use D68.59 When
  • According to ICD
  • 10 guidelines, D68
  • 59 should be used when the specific type of primary thrombophilia is not classified elsewhere
  • Coders must ensure that the diagnosis is supported by clinical documentation and laboratory findings
  • It is important to differentiate between primary and secondary thrombophilia to avoid coding errors

Exclusion Criteria

Do NOT use D68.59 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate platelet levels in patients suspected of having thrombophilia.

Documentation Requirements

Document the indication for the CBC and any relevant clinical findings.

Specialty Considerations

Hematologists may require additional tests to assess coagulation factors.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of thrombophilia, improving the accuracy of diagnoses and treatment plans. D68.59 provides a broader category for conditions that may not fit into more specific codes, allowing for better tracking and management of patients with these conditions.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of thrombophilia, improving the accuracy of diagnoses and treatment plans. D68.59 provides a broader category for conditions that may not fit into more specific codes, allowing for better tracking and management of patients with these conditions.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of thrombophilia, improving the accuracy of diagnoses and treatment plans. D68.59 provides a broader category for conditions that may not fit into more specific codes, allowing for better tracking and management of patients with these conditions.

Resources

Clinical References

  • •
    American Society of Hematology

Coding & Billing References

  • •
    American Society of Hematology

Frequently Asked Questions

What is the difference between primary and secondary thrombophilia?

Primary thrombophilia is typically inherited and results from genetic defects in the coagulation system, while secondary thrombophilia is acquired due to other medical conditions or risk factors, such as cancer or prolonged immobility.