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ICD-10 Guide
ICD-10 CodesD72.82

D72.82

Billable

Elevated white blood cell count

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D72.82 is a billable code used to indicate a diagnosis of elevated white blood cell count.

Key Diagnostic Point:

Elevated white blood cell count, or leukocytosis, is a condition characterized by an increase in the number of white blood cells (WBCs) in the bloodstream. This elevation can be a response to various physiological and pathological stimuli, including infections, inflammation, stress, and malignancies. Neutrophils, a type of white blood cell, are often the predominant cells involved in this condition, particularly in response to bacterial infections. Disorders of white blood cells can include leukemias, lymphomas, and myelodysplastic syndromes, which may present with abnormal WBC counts. Spleen disorders, such as splenomegaly or hypersplenism, can also affect WBC counts by sequestering or destroying these cells. Additionally, immunodeficiencies, whether congenital or acquired, can lead to abnormal WBC counts, as the body struggles to mount an adequate immune response. Accurate diagnosis and management of elevated WBC counts require a thorough clinical evaluation, including a complete blood count (CBC) and possibly bone marrow analysis, to determine the underlying cause and appropriate treatment.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of underlying causes leading to elevated WBC counts.
  • Differentiation between leukocytosis and other hematological disorders.
  • Potential for overlapping symptoms with other conditions.
  • Need for comprehensive documentation to support diagnosis.

Audit Risk Factors

  • Inadequate documentation of the underlying cause of elevated WBC.
  • Failure to specify the type of white blood cell involved.
  • Misclassification of leukocytosis as a primary diagnosis without supporting evidence.
  • Inconsistent coding practices across different healthcare settings.

Specialty Focus

Medical Specialties

Hematology

Documentation Requirements

Detailed lab results, including CBC and differential counts, and clinical notes explaining the rationale for testing.

Common Clinical Scenarios

Patients presenting with unexplained fever, infection, or fatigue requiring evaluation of blood counts.

Billing Considerations

Ensure that all relevant lab findings are documented to support the diagnosis of elevated WBC count.

Oncology

Documentation Requirements

Comprehensive history and physical examination, including any relevant imaging studies and pathology reports.

Common Clinical Scenarios

Patients with suspected hematological malignancies presenting with abnormal blood counts.

Billing Considerations

Documentation must clearly indicate the relationship between elevated WBC counts and any malignancies.

Coding Guidelines

Inclusion Criteria

Use D72.82 When
  • According to ICD
  • 10 coding guidelines, D72
  • 82 should be used when there is a documented elevated white blood cell count without a more specific diagnosis
  • It is essential to ensure that the underlying cause is well
  • documented to avoid coding errors

Exclusion Criteria

Do NOT use D72.82 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

85025CPT Code

Complete blood count (CBC) with differential

Clinical Scenario

Used to evaluate elevated WBC counts in patients presenting with symptoms of infection.

Documentation Requirements

Ensure that the clinical indication for the CBC is documented.

Specialty Considerations

Hematology specialists may require additional tests based on CBC results.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of elevated white blood cell counts, improving the ability to capture the complexity of these conditions and their underlying causes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of elevated white blood cell counts, improving the ability to capture the complexity of these conditions and their underlying causes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of elevated white blood cell counts, improving the ability to capture the complexity of these conditions and their underlying causes.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common causes of elevated white blood cell counts?

Common causes include infections, inflammation, stress responses, and hematological malignancies. Each cause may require different diagnostic approaches and treatments.