Other platelet-activating anti-PF4 disorders
ICD-10 D75.84 is a billable code used to indicate a diagnosis of other platelet-activating anti-pf4 disorders.
D75.84 refers to a specific category of disorders characterized by the presence of antibodies that activate platelets in the presence of platelet factor 4 (PF4). These disorders can lead to thrombocytopenia and are often associated with conditions such as heparin-induced thrombocytopenia (HIT). Patients may present with symptoms related to low platelet counts, including easy bruising, bleeding, and in severe cases, thrombosis. The pathophysiology involves an immune response where antibodies target the PF4 complex, leading to platelet activation and subsequent consumption. This condition can be complicated by associated white blood cell disorders, such as neutropenia, which may arise due to underlying autoimmune processes or as a side effect of treatments. Spleen disorders may also be relevant, as splenic sequestration can exacerbate thrombocytopenia. Additionally, immunodeficiencies may play a role in the development of these disorders, as a compromised immune system can lead to abnormal antibody production. Accurate diagnosis often requires a combination of clinical evaluation, laboratory tests, and sometimes bone marrow examination to rule out other hematological conditions.
Detailed lab results, patient history, and treatment plans must be documented.
Patients presenting with unexplained thrombocytopenia or recurrent thrombotic events.
Consideration of differential diagnoses and the need for comprehensive lab testing.
Immunological assessments and antibody testing results should be included.
Patients with autoimmune disorders presenting with hematological abnormalities.
Documentation of any underlying immunodeficiencies that may contribute to the condition.
Used to evaluate platelet counts and white blood cell disorders.
Document the reason for the CBC and any relevant clinical findings.
Hematologists may require additional tests based on CBC results.
Common symptoms include easy bruising, bleeding, and signs of thrombosis due to low platelet counts.
Diagnosis typically involves laboratory tests for anti-PF4 antibodies, complete blood counts, and clinical evaluation of symptoms.
