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v1.0.0
ICD-10 Guide
ICD-10 CodesD81.8

D81.8

Billable

Other combined immunodeficiencies

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 D81.8 is a billable code used to indicate a diagnosis of other combined immunodeficiencies.

Key Diagnostic Point:

Combined immunodeficiencies are a group of disorders characterized by the impaired function of both humoral and cell-mediated immunity. These conditions can lead to increased susceptibility to infections, autoimmune diseases, and malignancies. The term 'other combined immunodeficiencies' encompasses various specific immunodeficiency syndromes that do not fall under the more commonly recognized categories, such as severe combined immunodeficiency (SCID) or Wiskott-Aldrich syndrome. Patients may present with recurrent infections, failure to thrive, and other systemic complications. Diagnosis typically involves immunological testing, including lymphocyte subset analysis, serum immunoglobulin levels, and functional assays to assess immune response. Management may include immunoglobulin replacement therapy, prophylactic antibiotics, and in some cases, hematopoietic stem cell transplantation. The complexity of these conditions arises from their heterogeneous nature and the need for multidisciplinary care, including hematology, immunology, and infectious disease specialists.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of underlying genetic causes
  • Need for comprehensive immunological evaluation
  • Potential for overlapping symptoms with other disorders
  • Multidisciplinary management approach

Audit Risk Factors

  • Inadequate documentation of immunological testing
  • Failure to specify the type of combined immunodeficiency
  • Lack of evidence for recurrent infections
  • Insufficient detail on treatment plans

Specialty Focus

Medical Specialties

Immunology

Documentation Requirements

Detailed immunological assessment results, including lymphocyte counts and immunoglobulin levels.

Common Clinical Scenarios

Patients presenting with recurrent infections, failure to thrive, or autoimmune manifestations.

Billing Considerations

Ensure clear documentation of the specific immunodeficiency type and associated complications.

Hematology

Documentation Requirements

Complete blood counts, bone marrow biopsy results, and any relevant genetic testing.

Common Clinical Scenarios

Patients with hematologic abnormalities and signs of immunodeficiency.

Billing Considerations

Document any hematologic conditions that may coexist with immunodeficiency.

Coding Guidelines

Inclusion Criteria

Use D81.8 When
  • Follow the official ICD
  • CM coding guidelines, ensuring accurate documentation of the condition's specifics
  • Include any relevant laboratory findings and clinical assessments that support the diagnosis

Exclusion Criteria

Do NOT use D81.8 When
No specific exclusions found.

Related ICD-10 Codes

Related CPT Codes

36415CPT Code

Collection of venous blood by venipuncture

Clinical Scenario

Used for obtaining blood samples for immunological testing.

Documentation Requirements

Document the reason for blood collection and any relevant patient history.

Specialty Considerations

Ensure that the specialty performing the test is clearly documented.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, improving the accuracy of diagnoses and treatment tracking. D81.8 provides a broader classification for various combined immunodeficiencies that were previously grouped under less specific codes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, improving the accuracy of diagnoses and treatment tracking. D81.8 provides a broader classification for various combined immunodeficiencies that were previously grouped under less specific codes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of immunodeficiencies, improving the accuracy of diagnoses and treatment tracking. D81.8 provides a broader classification for various combined immunodeficiencies that were previously grouped under less specific codes.

Resources

Clinical References

  • •
    American Academy of Allergy, Asthma & Immunology

Coding & Billing References

  • •
    American Academy of Allergy, Asthma & Immunology

Frequently Asked Questions

What are the common symptoms of combined immunodeficiencies?

Common symptoms include recurrent infections, failure to thrive, autoimmune disorders, and increased susceptibility to certain cancers.