Immunodeficiency following hereditary defective response to Epstein-Barr virus
ICD-10 D82.3 is a billable code used to indicate a diagnosis of immunodeficiency following hereditary defective response to epstein-barr virus.
D82.3 refers to a specific immunodeficiency condition resulting from a hereditary defect in the immune system's response to the Epstein-Barr virus (EBV). This condition is characterized by an inability to mount an adequate immune response to EBV, which can lead to recurrent infections, particularly with EBV-associated diseases such as infectious mononucleosis and certain lymphoproliferative disorders. Patients may present with symptoms such as fatigue, fever, lymphadenopathy, and splenomegaly. The defective immune response can also predispose individuals to other viral infections and complications, including the development of malignancies like lymphomas. Diagnosis typically involves a combination of clinical evaluation, serological testing for EBV antibodies, and possibly genetic testing to identify the underlying hereditary defect. Management may include supportive care, prophylactic antibiotics, and in some cases, immunoglobulin therapy. Understanding the nuances of this condition is crucial for accurate coding and appropriate patient management.
Detailed patient history, including family history of immunodeficiency, clinical symptoms, and laboratory results.
Patients presenting with recurrent infections, unexplained lymphadenopathy, or splenomegaly.
Documentation must clearly link symptoms to EBV response defects.
Complete blood counts, lymphocyte subsets, and any relevant genetic testing results.
Patients with lymphoproliferative disorders or unexplained cytopenias.
Careful differentiation from other hematologic malignancies is essential.
Used to confirm EBV infection in patients with suspected D82.3.
Document the reason for testing and results.
Immunologists should ensure comprehensive testing for EBV-related complications.
Common symptoms include recurrent infections, fatigue, lymphadenopathy, and splenomegaly, often linked to EBV.
